Marked Elevation of Brain Natriuretic Peptide Levels in Pericardial Fluid Is Closely Associated With Left Ventricular Dysfunction

Tanaka, T; Hasegawa, Koji; Fujita, Masatoshi; Tamaki, Shunichi; Yamazato, A; Kihara, Yasuki; Nohara, Ryuji; Sasayama, Shígetake

doi:10.1016/s0735-1097(97)00482-8

Cited by 55 publications

(45 citation statements)

References 20 publications

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“…9 The suppression of procollagen by natriuretic peptides was previously reported. 10,11 Type I collagen and the carboxy-terminal propeptide of procollagen type I, a marker of collagen type I synthesis, are the major components of many extracellular matrices, and its accumulation characterizes most fibrotic processes.…”

Section: What Are the Pathophysiologic Roles Of Atrial Natriuretic Pementioning

confidence: 78%

The Roles of Natriuretic Peptides in Pericardial Fluid in Patients with Heart Failure

Watanabe

Kawaguchi

Nakahara

et al. 2009

Clinical Cardiology

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Background: It is well known that the plasma concentrations of atrial and brain natriuretic peptides, as cardiac hormones, are elevated in heart failure. Hypothesis: Pericardial fluid in patients with various heart diseases contains both natriuretic peptides that are released into the pericardial fluid. However, it is unknown whether these peptides reflect cardiac function in patients with various heart diseases, more than both the peptides in blood. Methods: Plasma and pericardial fluid samples were obtained from 22 patients undergoing cardiac surgery for the measurement of atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) levels in plasma and pericardial fluid. Results: The ANP levels in pericardial fluid were higher in patients with impaired left ventricular systolic function (ejection fraction <50% versus ≥50%; 77.0±4.9 versus 14.0±50.9, p = 0.017), but not BNP. However, BNP levels in pericardial fluid were significantly higher in patients with left ventricle dilatation (left ventricular diastolic dimension ≤54 mm versus >54 mm; 130.3±68.9: 709.7±324.7, p = 0.0168). Moreover, BNP levels in pericardial fluid were significantly higher in Grade III than Grade II and I (Grade I: echo-free space <5 mm, Grade II: 5-10 mm, Grade III: >10 mm). Conclusion: These results suggest that BNP levels in pericardial fluid served as more sensitive and accurate indicators of left ventricular diastolic dysfunction, and that increased BNP levels in pericardial fluid may have an important pathophysiologic role in heart failure as a cardiocyte-derived antifibrotic factor.

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Section: What Are the Pathophysiologic Roles Of Atrial Natriuretic Pementioning

confidence: 78%

The Roles of Natriuretic Peptides in Pericardial Fluid in Patients with Heart Failure

Watanabe

Kawaguchi

Nakahara

et al. 2009

Clinical Cardiology

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“…BNP is mainly derived from the left ventricular wall, and is increased in patients with left and/or right ventricular dysfunction [5-7, 27, 28]. These peptides are also secreted in the pericardial fluid [8,9]. A previous clinical study showed that ANP and BNP levels in the pericardial fluid were correlated with and higher than the respective blood levels, showing more marked increases due to cardiac failure [8].…”

Section: Discussionmentioning

confidence: 99%

“…However, objective assessment of the severity is very difficult. In clinical practice, atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), which are vasoactive hormones secreted by the heart, are routinely used for the diagnosis, management, and prognosis of heart diseases with cardiac insufficiency, and their pericardial levels are also useful for this purpose [4][5][6][7][8][9][10][11][12][13][14][15]. Although a number of reports have suggested that postmortem biochemistry is one of the most productive ancillary procedures available to forensic pathologists [16][17][18][19], there appears to be no published data on the natriuretic peptides in postmortem investigation.…”

Section: Introductionmentioning

confidence: 99%

Postmortem pericardial natriuretic peptides as markers of cardiac function in medico-legal autopsies

et al. 2006

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Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) in the blood are clinical markers for the diagnosis of cardiac failure. This study was a comprehensive analysis of the postmortem pericardial levels of the natriuretic peptides in serial medico-legal autopsy cases (n=263, within 72 h postmortem) to assess their validity in investigating cardiac function. There was no significant relationship of pericardial ANP or BNP levels with postmortem time or the age of the subjects. The ANP and BNP levels showed negative correlations with the pericardial cardiac troponin T level. The ANP level was significantly elevated in drowning cases. Pericardial BNP and the BNP/ANP ratio were significantly higher for chronic congestive heart disease. However, asphyxiation, sharp instrument injury, hyperthermia, and fatal MA poisoning cases showed lower levels for both markers. These observations suggest that elevations in the postmortem pericardial ANP and BNP may mainly depend on acute atrial overload and subacute or chronic cardiac failure, respectively, and may be reduced by advanced myocardial damage.

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“…Increased cardiac pressure or volume as well as neurohumoral factors can trigger the synthesis and release of peptides derived from proANP and proBNP. Circulating concentrations of ANP and NT-proANP primarily reflect increased preload, whereas BNP and NTproBNP concentrations primarily reflect increased heart afterload [47][48][49][50][51][52][53][54][55][56][57][58][59].…”

Section: Anp Bnp and N-terminal Propeptidesmentioning

confidence: 99%

Postmortem chemistry update part II

Palmière

Mangin

2011

Int J Legal Med

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As a continuation of "Postmortem Chemistry Update Part I," Part II deals with molecules linked to liver and cardiac functions, alcohol intake and alcohol misuse, myocardial ischemia, inflammation, sepsis, anaphylaxis, and hormonal disturbances. A very important array of new material concerning these situations had appeared in the forensic literature over the last two decades. Some molecules, such as procalcitonin and C-reactive protein, are currently researched in cases of suspected sepsis and inflammation, whereas many other analytes are not integrated into routine casework. As in part I, a literature review concerning a large panel of molecules of forensic interest is presented, as well as the results of our own observations, where possible.

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Marked Elevation of Brain Natriuretic Peptide Levels in Pericardial Fluid Is Closely Associated With Left Ventricular Dysfunction

Cited by 55 publications

References 20 publications

The Roles of Natriuretic Peptides in Pericardial Fluid in Patients with Heart Failure

The Roles of Natriuretic Peptides in Pericardial Fluid in Patients with Heart Failure

Postmortem pericardial natriuretic peptides as markers of cardiac function in medico-legal autopsies

Postmortem chemistry update part II

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