Markers for endothelial activation during open heart surgery

Eikemo, Hilde; Sellevold, Olav F Münter; Videm, Vibeke

doi:10.1016/s0003-4975(03)01060-9

Cited by 28 publications

(23 citation statements)

References 21 publications

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“…Our findings concerning patients undergoing CABG surgery with CPB are consistent with those of previous studies and are indicative of the endothelial inflammation/damage combined with the demonstrated coronary disease of the patients selected for CPB (18)(19)(20). However, in this study, plasma concentrations of five different biomarkers of endothelial origin were measured in adult patients undergoing on-pump coronary artery revascularization with hypothermic cardiac arrest three times; just before surgery, on the first and the third PD in order to examine endothelial injury and/or activation by means of CPB circuit in these patients.…”

Section: Discussionsupporting

confidence: 91%

Alterations in biomarkers of endothelial function following on‐pump coronary artery revascularization

Panagiotopoulos¹,

Palatianos²,

Michalopoulos³

et al. 2010

Clinical Laboratory Analysis

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Section: Discussionsupporting

confidence: 91%

Alterations in biomarkers of endothelial function following on‐pump coronary artery revascularization

Panagiotopoulos¹,

Palatianos²,

Michalopoulos³

et al. 2010

Clinical Laboratory Analysis

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“…During open heart surgery, a clinical setting with acute endothelial activation, sVCAM‐1 is liberated in larger quantities than sICAM‐1 and changes are therefore easier to detect [6]. We therefore hypothesized that sVCAM‐1 may be a more useful marker.…”

Section: Introductionmentioning

confidence: 99%

Soluble ICAM‐1 and VCAM‐1 as Markers of Endothelial Activation

2008

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Activated endothelium releases the soluble adhesion molecules vascular cell adhesion molecule‐1 (sVCAM‐1) and intercellular adhesion molecule‐1 (sICAM‐1). Measurement of fluid‐phase adhesion molecules is therefore used to quantify endothelial activation, but it is unclear which is the better marker. The aims of the study were to compare the relationships between mRNA, surface and total expression and released VCAM‐1 and ICAM‐1 in endothelial cell cultures during activation, and to compare human umbilical vein endothelial cells (HUVEC) with the microvascular cell line HMEC‐1. sVCAM‐1 better represented mRNA and surface expression changes in HUVEC undergoing endotoxin stimulation than did sICAM‐1. Very little VCAM‐1 was released from endotoxin‐stimulated HMEC‐1, and sICAM‐1 seemed a better activation marker for these cells. During incubation of HUVEC in media with glucose concentrations of 5.6, 10.6 or 20.6 mm, VCAM‐1 was released to the media in a dose‐dependent way without changes in surface expression. ICAM‐1 was not influenced by the glucose concentration. There are situations when VCAM‐1 concentrations in the media do not mirror the surface expression on HUVEC in culture, indicating that measurements of soluble adhesion molecules may not necessarily be representative of the conditions on the cell surface. Endothelium from different locations showed varying responses with respect to VCAM‐1 and ICAM‐1 liberation upon endotoxin stimulation. Thus, both sVCAM‐1 and sICAM‐1 should be quantified in clinical studies of endothelial activation until their characteristics are better clarified.

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“…Elevated adhesion molecules have also been reported in patients with systemic inflammatory response syndrome, sepsis, and multiple organ failure (16)(17)(18)(19). These clinic syndromes and LCOS are inseparable parameters especially in critically ill patients.…”

Section: Discussionmentioning

confidence: 99%

Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

Yıldırım¹,

Güzelmeriç²,

Oner³

et al. 2014

Anadolu Kardiyol Derg

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Objective: To investigate preoperative and postoperative blood levels of soluble intercellular and vascular cell adhesion molecules (sICAM-1, sVCAM-1) in patients with and without pulmonary hypertension (PAH) due to congenital heart disease and left to right (L-R) shunt and to determine whether these molecules can be used as reliable prognostic markers of endothelial activity to predict surgical outcomes. Methods: In this observational prospective cohort study; 42 patients, operated for L-R shunt were divided into three groups. Group 1: L-R shunt without PAH, Group 2: L-R shunt with PAH, Group 3: L-R shunt with PAH and postoperative low cardiac output syndrome (LCOS). Their sICAM-1 and sVCAM-1 levels were measured preoperatively (sICAM-0, sVCAM-0) and on the first (sICAM-1, sVCAM-1) and fifth postoperative days (sICAM-2, sVCAM-2).ROC curve for various cut-off levels of sICAM-0, sVCAM-0 in differentiating PAH patients with and without LCOS. Results: In Group 3, sICAM-0 and sVCAM-2 levels were higher than Group 1 and 2. The ROC curve demonstrated a significant association between sICAM-0 in patients with L-R shunt and PAH (Group 2 and 3) and the development of LCOS (area under the curve: 0.98, p<0.01 and 0.97, p<0.01, respectively). At a sICAM-0 concentration >359 ng/mL, there was a sensitivity of 90% and specificity of 95% for identification of LCOS in patients with L-R shunt and PAH (AUC: 0.98, 95% CI: 0.95-1.02, p<0.01). Conclusion: High preoperative sICAM-1 molecule may be used to predict postoperative dichotomous outcome in patients with PAH associated with L-R shunt. (Anadolu Kardiyol Derg 2014; 14: 274-9)

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Markers for endothelial activation during open heart surgery

Cited by 28 publications

References 21 publications

Alterations in biomarkers of endothelial function following on‐pump coronary artery revascularization

Alterations in biomarkers of endothelial function following on‐pump coronary artery revascularization

Soluble ICAM‐1 and VCAM‐1 as Markers of Endothelial Activation

Prognostic significance of sICAM-1 and sVCAM-1 Molecules for cardiac surgery in pediatric patients with pulmonary hypertension

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