Markers for visceral hypersensitivity in patients with irritable bowel syndrome

Abstract

Apart from more severe symptomatology, hypersensitive IBS patients are characterized by significantly younger age compared with normosensitive IBS patients. The study has been registered in the US National Library of Medicine (http://www.clinicaltrials.gov, NCT00702026).

The Role of Visceral Hypersensitivity in Irritable Bowel Syndrome: Pharmacological Targets and Novel Treatments

“…154 Given the fact that VH is considered as a paramount clinical manifestation observed in patients with IBS, assessment practices of pain sensation such as modern imaging methods, as well as the barostat method, possess an increased interest to understand mechanisms of visceroperception in IBS. 13 Dysregulation in the afferent part of the brain-gut axis possesses the potential to induce VH. It has been reported that several novel compounds which possess multiple gastrointestinal pharmacological effects can be considered as future drugs for managing VH in IBS patients.…”

“…[27][28][29] VH generally occurs in IBS-D patients, who have increased intestinal permeability. 13,30 Clinical studies demonstrated that the severity of IBS complications in patients with hypersensitivity IBS is dramatically higher than other IBS patients. Although primary investigations have restricted the occurrence of VH to the rectum and sigmoid colon, numerous studies reported that decreased thresholds of nociceptive sensation were observed within other parts of the gut including the small bowel, stomach, as well as the esophagus, indicating the spread of VH within all over the gut.…”

“…1,11 Several underlying mechanisms could be discussed in the pathophysiology of IBS as a multifactorial disease. Inflammatory reactions, history of childhood infections, 12 hypersensitivity and alteration in visceral perception, 13,14 gastrointestinal dysmotility, changes in gut microflora, emotional and psychological triggers, increase in intestinal permeability and food intolerance as well as genetic variations in bile acid secretion are amongst suggested reasons for IBS development.…”

Piezo2: A Candidate Biomarker for Visceral Hypersensitivity in Irritable Bowel Syndrome?

“…5 With lower thresholds for pain as well as increased intensity of sensations, visceral hypersensitivity makes a great contribution to abdominal pain, which is the most predominant and distressing symptom of IBS. 6 Diagnosis of visceral hypersensitivity is generally performed with barostat controlled rectal distention. 7 The feeling and pain thresholds were evaluated.…”

Роль Вісцеральної Гіперчутливості В Розвитку Синдрому Подразненого Кишечника

“…При сравнении групп пациентов с повышенной и нормальной висцеральной чувстви-тельностью кишечника по данным баростата в иссле-довании было установлено, что ВГЧ достоверно выше у более молодых пациентов по сравнению с более старшими [22]. Для лучшей стандартизации проце-дуры ректального баростата в 2012 г. было проведено исследование, которое оценивало порог ВГЧ с учетом использования визуальной аналоговой шкалы.…”