Markers of Endothelial Dysfunction in Complicated and Uncomplicated Forms of Influenza in Children

Miromanova, N.A.; Мироманов, А. М.

doi:10.22625/2072-6732-2016-8-4-66-71

Cited by 2 publications

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“…Известно, что эндотелий -это активная метаболическая система, поддерживающая сосудистый гомеостаз различными функциями, одной из которых является модуляция сосудистого тонуса [21]. Эндотелиальная дисфункция является одним из главных патогенетических звеньев многих заболеваний [22][23][24]. Значимый маркер дисфункции эндотелия -изменение уровня гомоцистеина в крови [11].…”

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Clinical case of thrombosis in a newborn child with congenital heart disease against the background of hereditary thrombophilia

Filippova

Вахлова

Кузнецов

et al. 2022

jour

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Introduction. The problem of neonatal thrombosis is becoming increasingly urgent in clinical practice due to its importance in the development of a complicated course of the neonatal period in children with hereditary and acquired thrombogenic risk factors. The aim of the investigation is to present a clinical case of multiple thromboses in a premature newborn infant with congenital heart disease on the background of multigenic thrombophilia, complicated by neonatal sepsis. Materials and methods. Materials for the investigation were the primary medical records: history of the newborn, medical history of the patient-newborn child with the established diagnosis of great-vessel thrombosis, with the congenital heart disease and the presence of genetic thrombophilia, who was under observation for 2 months. The findings of objective, laboratory (clinical blood tests, investigation of hemostasis parameters, homocysteine concentration, molecular-genetic study of hemostasis enzymes genes, folate cycle enzymes genes) and instrumental (CT angiography, ultrasonic examination of abdominal cavity and retroperitoneal organs, ECHO cardiography, ultrasonic Dopplerography) research methods were evaluated. Results and Discussion. In the clinical observation under consideration, there was a burdened molecular genetic background consisting of carriage of plasminogen activator inhibitor gene polymorphisms and folate cycle enzyme genes: MTHFR 677 – C/T, MTHFR 2756 – A/G, MTRR 66 – G/G, and hyperhomocysteinemia were the factors responsible for multiple thrombosis in a patient born with critical congenital heart disease (CHD), contributed to generalization of the infection process with the development of multiple organ failure, and exacerbated the postoperative period after correction of heart disease. Conclusion. The clinical case demonstrates the development of multiple thrombosis and septic process in a child born with CHD. The results of molecular genetic study proved the presence of hereditary thrombophilia in the child, which was a predictor of thrombosis development and probably a risk factor aggravating the severity of generalized infectious process, which complicated pre- and postoperative periods of the main disease, CHD.

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Clinical case of thrombosis in a newborn child with congenital heart disease against the background of hereditary thrombophilia

Filippova

Вахлова

Кузнецов

et al. 2022

jour

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“…В настоящее время эндотелий рассматривается как активная метаболическая система, поддерживающая сосудистый гомеостаз путем осуществления разнообразных функций (модуляция сосудистого тонуса, регуляция хемотаксических, репаративных и воспалительных процессов в ответ на локальное повреждение, формирование внеклеточного матрикса) [4]. Принимая во внимание широкий спектр причин, приводящих к изменению нормального функционирования сосудистого эндотелия, на сегодняшний момент удалось установить, что эндотелиальная дисфункция является неизменным патогенетическим звеном широкого круга заболеваний и состояний [5][6][7].…”

Section: Doi: 1022625/2072-6732-2018-10-1-42-46unclassified

Diagnostic Meaning of Determination of Homocystein in the Blood Serum in Children With Neuroinfections

Berezovskaya¹,

Miromanova²

2018

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The aim of the study was to determine the serum level of homocysteine in children with neuroinfections. Mаterials and methods: A blood serum assay of 60 children with viral and bacterial neuroinfections was performed using the enzyme immunoassay to evaluate homocysteinemia as a marker of endothelial dysfunction. Results: In interpreting the results, the average level of hyperhomocysteinemia in patients with bacterial and viral neuroinfections was established. The highest homocysteine levels in serum were observed in bacterial neuroinfections, especially in the presence of signs of meningoencephalitis and pneumococcal etiology of the disease. Dependence of changes in the level of homocysteinemia from the sex of sick children was not revealed. Conclusion: Neuroinfections in children, regardless of the cause, are accompanied by hyperhomocysteinemia, indicating the presence of endothelial activation in this pathology, more pronounced in the case of a bacterial etiology of the infectious process and the combined lesion of the soft dura mater and the brain substance.

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Markers of Endothelial Dysfunction in Complicated and Uncomplicated Forms of Influenza in Children

Cited by 2 publications

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Clinical case of thrombosis in a newborn child with congenital heart disease against the background of hereditary thrombophilia

Clinical case of thrombosis in a newborn child with congenital heart disease against the background of hereditary thrombophilia

Diagnostic Meaning of Determination of Homocystein in the Blood Serum in Children With Neuroinfections

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