Masou salmon (Oncorhynchus masou) ethanol extract decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase expression in diet-induced obese mice

Oh, Hyun‐Taek; Chung, Mi Ja; Kim, Soohyun; Choi, Hyun-Jin; Ham, Seung-Shi

doi:10.1016/j.nutres.2008.11.006

Cited by 13 publications

(9 citation statements)

References 45 publications

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“…Our observations are consistent with those of other studies [7,9,11,15,16,19] reported that inotodiol had an in vivo antitumor effect against P388-bearing mice. Inonotus obliquus appears to have an abundance of triterpenes, including lanosterol and inotodiol [9].…”

Section: Discussionsupporting

confidence: 94%

“…Inotodiol has an OH group at position 22 (C-22) of lanosterol [9]. The chemical structure of the compound in subfraction 3 was determined by comparing the MS, 1 H-NMR, and 13 C-NMR spectra (data not shown) to published library spectra and spectra in the literature [7,9,15,16]. These analyses revealed that subfraction 3 is lanosterol.…”

Section: Resultsmentioning

confidence: 99%

“…After 24 h, the mice were fed normal chow supplemented with water (control group), 0.1 mg subfraction 1 per mouse per day (S-180+subfraction 1A), 0.2 mg subfraction 1 per mouse per day (S-180+subfraction 1B), 0.1 mg subfraction 2 per mouse per day (S-180+subfraction 2A), 0.2 mg subfraction 2 per mouse per day (S-180+subfraction 2B), 0.1 mg subfraction 3 per mouse per day (S-180+subfraction 3A) or 0.2 mg subfraction 3 per mouse per day (S-180+subfraction 3B) for 20 days. The mice were fed normal chow for 7 days after the last oral administration of subfractions and then euthanized with an ip injection of Avertin (Sigma-Aldrich Co., St. Louis, MO, USA) [15] on the 27 th day after cancer-cell implantation. Solid tumors were removed and weighed, and the tumor-growth-inhibition ratio (I.R.)…”

Section: Methodsmentioning

confidence: 99%

“…The level of statistical significance was set at P <0.05. The comparisons of cancer cell growth inhibition in vitro and solid tumor growth inhibition in vivo among the groups were performed using Duncan's multiple range test [15]. …”

Section: Methodsmentioning

confidence: 99%

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Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Chung

Jeong

et al. 2010

Nutr Res Pract

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The Chaga mushroom (Inonotus obliquus) has been used in folk medicine to treat cancers. However, limited information exists on the underlying anticancer effects of the major component of I. obliquus in vivo. We hypothesize that the pure compounds (3β-hydroxy-lanosta-8,24-dien-21-al, inotodiol and lanosterol, respectively) separated from I. obliquus would inhibit tumor growth in Balbc/c mice bearing Sarcoma-180 cells (S-180) in vivo and growth of human carcinoma cells in vitro. To test this hypothesis, the growth inhibition of each subfraction isolated from I. obliquus on human carcinoma cell lines (lung carcinoma A-549 cells, stomach adenocarcinoma AGS cells, breast adenocarcinoma MCF-7 cells, and cervical adenocarcinoma HeLa cells) was tested in vitro. Then, after S-180 implantation, the mice were fed a normal chow supplemented with 0, 0.1 or 0.2 mg of subfraction 1, 2 or 3 per mouse per day. All of the subfractions isolated from I. obliquus showed significant cytotoxic activity against the selected cancer cell lines in vitro. Subfraction 1 was more active than subfraction 2 and subfraction 3 against the A549, AGS and MCF-7 cancer cell lines in vitro. In in vivo results, subfraction 1 isolated from I. obliquus at concentrations of 0.1 and 0.2 mg/mouse per day significantly decreased tumor volume by 23.96% and 33.71%, respectively, as compared with the control. Subfractions 2 and 3 also significantly inhibited tumor growth in mice bearing S-180 as compared with the control mouse tumor. Subfraction 1 isolated from I. obliquus showed greater inhibition of tumor growth than subfractions 2 and 3, which agrees well with the in vitro results. The results suggest that I. obliquus and its compounds in these subfractions isolated from I. obliquus could be used as natural anticancer ingredients in the food and/or pharmaceutical industry.

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Section: Discussionsupporting

confidence: 94%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Chung

Jeong

et al. 2010

Nutr Res Pract

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“…25,27) ARW intake increased HMG-CoA reductase expression although insignificant, we think this is in compatible to previous finding that hepatic HMG-CoA reductase expression is markedly down-regulated in HFD mice. 28,29) Together, we suggest that, ARW intake may influence cholesterol homeostasis in the liver via regulation of CYP7A1 activity.…”

Section: Discussionmentioning

confidence: 71%

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Ignacio

Kang

Kim

et al. 2013

Biological & Pharmaceutical Bulletin

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Whether or not alkaline reduced water (ARW) has a positive effect on obesity is unclear. This study aims to prove the positive effect of ARW in high-fat (HF) diet-induced obesity (DIO) in C57BL/6 mice model. Toward this, obesity was induced by feeding the C57BL/6 male mice with high-fat diet (w/w 45% fat) for 12 weeks. Thereafter, the animals were administered with either ARW or tap water. Next, the degree of adiposity and DIO-associated parameters were assessed: clinico-pathological parameters, biochemical measurements, histopathological analysis of liver, the expression of cholesterol metabolism-related genes in the liver, and serum levels of adipokine and cytokine. We found that ARW-fed mice significantly ameliorated adiposity: controlled body weight gain, reduced the accumulation of epididymal fats and decreased liver fats as compared to control mice. Accordingly, ARW coordinated the level of adiponectin and leptin. Further, mRNA expression of cytochrome P450 (CYP)7A1 was upregulated. In summary, our data shows that ARW intake inhibits the progression of HF-DIO in mice. This is the first note on anti-obesity effect of ARW, clinically implying the safer fluid remedy for obesity control.Key words alkaline reduced water; adiponectin; cytokine; adiposity; epididymal fat; cholesterol 7α-hydroxylase Obesity has reached global epidemic status. In developed and developing countries, obesity is reported to be the sixth most important risk factor contributing to the overall burden of chronic disease.1) Forty three million children, 82% of which from developing countries, are affected with obesity.2)The World Health Organization recently reported that there were more than 1 billion overweight adults worldwide, of whom 500 million were obese.3) Obesity poses a major public health issue as it is known to be positively associated with increased risk of certain chronic diseases such as cardiovascular disease, hypertension, type 2 diabetes and fatty liver. [3][4][5] Excessive intake of dietary fats influences the progression of obesity, 6) which is characterized by accumulation of body fats marked by abnormal increase in adipose tissue mass and liver fats (adiposity), dysregulated levels of adipokines, and imbalance between pro-and anti-inflammatory cytokine. 7-9)The complexity of these pathogenetic mechanisms of obesity poses a challenge to the development of effective therapy. In that context, there has been growing concern for the need of newer therapeutic strategies that directly deal with these mechanisms. Of several such candidates, we first introduced the alkaline reduced water (ARW) for obesity control in highfat (HF) diet-induced obesity (DIO) in mice model. ARW refers to electrolyzed water produced from minerals such as magnesium and calcium, which is characterized by supersaturated hydrogen, high pH, and a negative oxidation reduction potential. This hydrogen-rich functional water has been introduced as a feasible therapeutic strategy for health promotion and disease prevention. [10][11][12] Our previous studies ...

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Platycodon grandiflorum root attenuates vascular endothelial cell injury by oxidized low-density lipoprotein and prevents high-fat diet–induced dyslipidemia in mice by up-regulating antioxidant proteins

et al. 2012

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Masou salmon (Oncorhynchus masou) ethanol extract decreases 3-hydroxy-3-methylglutaryl coenzyme A reductase expression in diet-induced obese mice

Cited by 13 publications

References 45 publications

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Anticancer activity of subfractions containing pure compounds of Chaga mushroom (Inonotus obliquus) extract in human cancer cells and in Balbc/c mice bearing Sarcoma-180 cells

Anti-obesity Effect of Alkaline Reduced Water in High Fat-Fed Obese Mice

Platycodon grandiflorum root attenuates vascular endothelial cell injury by oxidized low-density lipoprotein and prevents high-fat diet–induced dyslipidemia in mice by up-regulating antioxidant proteins

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