Mass drug administration for the prevention human strongyloidiasis should consider concomitant treatment of dogs

Beknazarova, Meruyert; Whiley, Harriet; Ross, Kirstin

doi:10.1371/journal.pntd.0005735

Cited by 10 publications

(12 citation statements)

References 24 publications

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“…While this does not prove the potential of dogs as a reservoir of S. stercoralis , it supports the hypothesis of zoonotic transmission in remote Australian communities. As discussed previously and with respect to the One Health approach, we suggest that humans and dogs should be treated concomitantly in these communities to control strongyloidiasis (Beknazarova et al, 2017b, Jaleta et al, 2017). Ultimately, we confirm for the first time that potentially zoonotic S. stercoralis genotypes are present in Australia and suggest that dogs represent a potential reservoir of human strongyloidiasis in remote Australian communities.…”

Section: Discussionmentioning

confidence: 92%

“…The zoonotic potential of S. stercoralis infected dogs and their potential role in the maintenance of strongyloidiasis transmission has been a topic of interest and discussion for many years (Beknazarova et al, 2017b, Goncalves et al, 2007, Takano et al, 2009). Molecular investigation of human and dog derived S. stercoralis is useful in understanding the nature of cross infection.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of classic and cryptic Strongyloides genotypes by deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities

Beknazarova

Barratt

Bradbury

et al. 2019

Preprint

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17Strongyloidiasis is a neglected disease caused by the human infective nematodes 18 Strongyloides stercoralis, Strongyloides fuelleborni subsp. fuelleborni and Strongyloides 19 fuelleborni subsp. kellyi. The zoonotic potential of S. stercoralis and the potential role of dogs 20 in the maintenance of strongyloidiasis transmission has been a topic of interest and discussion 21 for many years. In Australia, strongyloidiasis is prevalent in remote socioeconomically 22 disadvantaged communities in the north of the continent. Being an isolated continent that has 23 been separated from other regions for a long geological period, knowledge on the diversity of 24 Australian Strongyloides genotypes is an important addition to our understanding of the genetic 25 diversity within the genus. Using PCR enrichment combined with Illumina sequencing 26 technology, we sequenced the Strongyloides SSU 18S rDNA hyper-variable I and hyper-27 variable IV regions using Strongyloides-specific primers, and a fragment of the mtDNA cox128 gene using primers that are broadly specific for Strongyloides sp. and hookworms. These loci 29 were amplified from DNA extracted from human and dog faeces, and one human sputum 30 sample. Using this approach, we confirm for the first time that potentially zoonotic S.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Detection of classic and cryptic Strongyloides genotypes by deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities

Beknazarova

Barratt

Bradbury

et al. 2019

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Evidence is emerging that dogs may act as hosts for human strongyloidiasis in some settings [ 44 , 45 ]. Animal services in remote communities are often limited, leading to animal over-population in some areas [ 46 ].…”

Section: Discussionmentioning

confidence: 99%

“…Animal services in remote communities are often limited, leading to animal over-population in some areas [ 46 ]. Community-based interventions may need to consider incorporating animal management into programs to address this potential reservoir [ 44 ].…”

Section: Discussionmentioning

confidence: 99%

Paediatric Strongyloidiasis in Central Australia

Wilson

Fearon

2018

TropicalMed

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Few published studies are available describing the prevalence of paediatric strongyloidiasis in endemic areas within Australia. This literature review and exploratory clinical audit presents the first seroprevalence data for paediatric patients in Central Australia. A total of 16.1% (30/186) of paediatric inpatients tested for Strongyloides stercoralis in 2016 were seropositive (95% CI: 11.5% to 22.1%). Eosinophilia of unknown aetiology was the most common indication for testing (91.9%). Seropositive patients were significantly more likely to reside in communities outside of Alice Springs (p = 0.02). Seropositive patients were noted to have higher mean eosinophil counts with a mean difference of 0.86 × 109/L (95% CI: 0.56 to 1.16, p < 0.0001), although the limited utility of eosinophilia as a surrogate marker of strongyloidiasis has been described previously. All seropositive patients were Indigenous. There was no significant difference in ages between groups. There was a male predominance in the seropositive group, although this was not significant (p = 0.12). Twelve patients had known human T-lymphotropic virus 1 (HTLV-1) status and all were seronegative. Further research describing the epidemiology of strongyloidiasis in Central Australia is required.

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“…The concept of strongyloidiasis as a zoonotic infection is becoming a subject of renewed interest where evidence from DNA sequence polymorphism analysis revealed humans and dogs from the same community sharing a S. stercoralis strain that suggests a potential role for dogs in transmission 31 . This raises the possibility that dogs should also be targeted for treatment in the setting of human deworming campaigns 32…”

Section: Transmissionmentioning

confidence: 99%

Strongyloidiasis

Krolewiecki

Nutman

2019

Infectious Disease Clinics of North America

159

105

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The majority of the 30-100 million people infected with Strongyloides stercoralis, a soil transmitted intestinal nematode, have subclinical (or asymptomatic) infections. These infections are commonly chronic and longstanding because of the parasite's unique life cycle that allows for autoinfection. A change in immune status can increase parasite numbers, leading to hyperinfection syndrome, dissemination, and death if unrecognized. The use of corticosteroids and HTLV-1 infection are most commonly associated with the hyperinfection syndrome. Strongyloides adult parasites reside in the small intestine and induce immune responses both local and systemic that are like other nematodes. Definitive diagnosis of S. stercoralis infection is based on stool examinations for larvae, but newer diagnostics-including new immunoassays and molecular tests-will assume primacy in the next few years. Although good treatment options exist for infection and control of this infection, S. stercoralis remains largely neglected.

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Mass drug administration for the prevention human strongyloidiasis should consider concomitant treatment of dogs

Cited by 10 publications

References 24 publications

Detection of classic and cryptic Strongyloides genotypes by deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities

Detection of classic and cryptic Strongyloides genotypes by deep amplicon sequencing: A preliminary survey of dog and human specimens collected from remote Australian communities

Paediatric Strongyloidiasis in Central Australia

Strongyloidiasis

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