Mass Spectrometry in Biophysics 2005
DOI: 10.1002/0471705179.ch5
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Mass Spectrometry‐Based Approaches to Study Biomolecular Dynamics: Equilibrium Intermediates

Abstract: In the preceding chapter, we surveyed various MS-based approaches to study higher-order structure of proteins under native conditions. For many decades, such well-defined and highly organized structures were thought of as the most important (if not the only) determinants of protein function. Protein folding was often considered a linear process leading from fully unstructured (and, therefore, dysfunctional) states to the highly organized native (function-competent) state. The advent of NMR has changed our perc… Show more

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