Mass spectrometry in aging research

Schöneich, Christian

doi:10.1002/mas.20035

Cited by 21 publications

(12 citation statements)

References 201 publications

(186 reference statements)

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“…Global gene expression profiling has been used to characterise transcriptional changes associated with age and longevity, as discussed in several recent reviews [1-6]. Proteomics and metabolomics technologies are also now being applied to ageing-related problems [7,8] and, as these technologies continue to mature, will certainly be used more extensively. One particularly important application of these technologies will be the identification of diagnostic biomarkers of ageing and ageing rate [9-12].…”

Section: Introductionmentioning

confidence: 99%

Genome-wide approaches to understanding human ageing

Kaeberlein

2006

Hum Genomics

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Section: Introductionmentioning

confidence: 99%

Genome-wide approaches to understanding human ageing

Kaeberlein

2006

Hum Genomics

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“…(23,64 ) Myocardial inflammation (5 ) tion factors, the adaptor protein p66Shc, and the histone deacetylase Sir2-are all involved in either regulating the concentrations of intracellular ROS in mammalian cells or increasing oxidative stress resistance (9 ). It is now well established that biological aging correlates with the accumulation of oxidized biomolecules in most tissues (11)(12)(13). In the study of age-related increases in concentrations of oxidized biomolecules, disparities have been observed between intracellular and extracellular proteins.…”

mentioning

confidence: 99%

Biomarkers of Oxidative Damage in Human Disease

et al. 2006

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Oxidative/nitrosative stress, a pervasive condition of increased amounts of reactive oxygen/nitrogen species, is now recognized to be a prominent feature of many acute and chronic diseases and even of the normal aging process. However, definitive evidence for this association has often been lacking because of recognized shortcomings with biomarkers and/or methods available to assess oxidative stress status in humans. Emphasis is now being placed on biomarkers of oxidative stress, which are objectively measured and evaluated as indicators of normal biological processes, pathogenic processes, or pharmacologic responses to therapeutic intervention. To be a predictor of disease, a biomarker must be validated. Validation criteria include intrinsic qualities such as specificity, sensitivity, degree of inter-and intraindividual variability, and knowledge of the confounding and modifying factors. In addition, characteristics of the sampling and analytical procedures are of relevance, including constraints and noninvasiveness of sampling, stability of potential biomarkers, and the simplicity, sensitivity, specificity, and speed of the analytical method. Here we discuss some of the more commonly used biomarkers of oxidative/nitrosative damage and include selected examples of human studies.

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“…In recent years much support has been accumulated for the involvement of oxidative stress in aging (Finkel and Holbrook, 2000;Hekimi and Guarente, 2003). It is now well established that biological aging correlates with the accumulation of oxidized biomolecules such as oxidized proteins , lipids, DNA bases, advanced glycation end-products (AGEs), and lipofuscin (Schoneich, 2005) in most tissues.…”

Section: Oxidative Stress In Human Diseases and Animal Modelsmentioning

confidence: 99%