Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization

Monge, Marı́a Eugenia; Harris, Geoffrey; Dwivedi, Prabha; Fernández, Facundo M.

doi:10.1021/cr300309q

Cited by 448 publications

(378 citation statements)

References 452 publications

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“…Ambient ionization [6][7][8][9][10][11][12][13][14] is a relatively recent approach to MS analysis which avoids chromatography and is characterized by the absence of any requirement for sample preparation. Paper spray ionization [15][16][17][18][19][20] is a particularly simple ambient ionization technique which can be employed to study reactions and identify intermediates as well as to measure trace constituents of complex mixtures.…”

Section: Introductionmentioning

confidence: 99%

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Bag

Hendricks

Reynolds

et al. 2015

Analytica Chimica Acta

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Ionization of aliphatic and aromatic aldehydes is improved by performing simultaneous chemical derivatization using 4-aminophenol to produce charged iminium ions during paper spray ionization.Accelerated reactions occur in the microdroplets generated during the paper spray ionization event for the tested aldehydes (formaldehyde, n-pentanaldehyde, n-nonanaldehyde, n-decanaldehyde, ndodecanaldehyde, benzaldehyde, m-anisaldehyde, and p-hydroxybenzaldehyde). Tandem mass spectrometric analysis of the iminium ions using collision-induced dissociation demonstrated that straight chain aldehydes give a characteristic fragment at m/z 122 (shown to correspond to protonated 4-(methyleneamino)phenol), while the arylaldehydeiminium ions fragment to give a characteristic product ion at m/z 120. These features allow straightforward identification of linear and aromatic aldehydes. Quantitative analysis of n-nonaldehyde using a benchtop mass spectrometer demonstrated a linear response over 3 orders of magnitude from 2.5 ng -5 µg of aldehyde loaded on the filter paper emitter. The limit of detection was determined to be 2.2 ng for this aldehyde. The method had a precision of 22%, relative standard deviation. The experiment was also implemented using a portable ion trap mass spectrometer.3

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Section: Introductionmentioning

confidence: 99%

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Bag

Hendricks

Reynolds

et al. 2015

Analytica Chimica Acta

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“…Of course, there are numerous other ionization approaches that have been used for a wide range of applications, ranging from relatively recently developed ambient sampling techniques such as desorption ESI (Takáts et al, 2004) or direct analysis in real time (DART) (Cody et al, 2005) to well-established techniques such as matrix assisted laser desorption ionization. Atmospheric pressure, ambient, and desorption techniques have been reviewed extensively in recent years (Covey et al, 2009;Monge et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Theory and Practice of UHPLC and UHPLC–MS

Guillarme

Veuthey

2017

Handbook of Advanced Chromatography /Mass Spectrometry Techniques

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“…For DART and other atmospheric pressure chemical ionization (APCI) methods, a glow or corona discharge is deployed. Although abundant ion formation occurs when analytes are exposed to discharges, the overall mechanism of ionization remains poorly defined [5][6][7][8][9][10][11][12][13], and the need to understand it has been duly recognized [14,15]. It is agreed that a complex cascade of gas-phase interactions take place before the target molecules are eventually charged [15,16].…”

Section: Introductionmentioning

confidence: 99%

Regulated In Situ Generation of Molecular Ions or Protonated Molecules under Atmospheric-Pressure Helium-Plasma-Ionization Mass Spectrometric Conditions

Gangam

Pavlov

Attygalle

2015

J. Am. Soc. Mass Spectrom.

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Abstract. In an enclosed atmospheric-pressure helium-plasma ionization (HePI) source engulfed with dehumidified ambient gases, molecular cations are generated from compounds such as toluene, bromobenzene, and iodobenzene. Evidently, the ionization is effected by a direct Penning mechanism attributable to interactions of the gas-phase analyte with metastable helium atoms. It is widely known that secondary ions generated from ambient gases also play an important role in the overall ionization process. For example, when the ambient gases bear even traces of moisture, the analytes are ionized by proton transfer reactions with gaseous H 3 O + . In this study, we demonstrate how a controlled variation of experimental conditions can manipulate the abundance of molecular ions and protonated molecules in a HePI source.

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Mass Spectrometry: Recent Advances in Direct Open Air Surface Sampling/Ionization

Cited by 448 publications

References 452 publications

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Biogenic aldehyde determination by reactive paper spray ionization mass spectrometry

Theory and Practice of UHPLC and UHPLC–MS

Regulated In Situ Generation of Molecular Ions or Protonated Molecules under Atmospheric-Pressure Helium-Plasma-Ionization Mass Spectrometric Conditions

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