Massive Exudative Retinal Detachment After Photodynamic Therapy for Peripheral Retinal Capillary Hemangioma

Abstract

Photodynamic therapy monotherapy to treat retinal capillary hemangioma might result in a massive exudative retinal detachment requiring surgery.

Resolution of epiretinal membrane after anti-VEGF and photodynamic therapy of retinal hemangioblastoma

“…Retinal hemangioblastoma (RH) is a benign retinal vascular tumor that usually appear as a round-shaped, orange-red mass, and may be observed isolated or in the context of von Hippel–Lindau disease (VHL). 1 , 2 , 3 …”

“…RH can sometimes result in visual deterioration due to its location or complications, such as macular extension of intraretinal or subretinal fluid, exudation, presence of an epiretinal membrane or vitreoretinal traction, vitreous hemorrhage, and the presence of serous or tractional retinal detachment. 2 , 3 …”

Massive Exudative Retinal Detachment Following Photodynamic Therapy and Intravitreal Bevacizumab Injection in Retinal Capillary Hemangioma

“…The condition in which RCH is accompanied by intracranial hemangioblastomas and cysts in abdominal organs such as kidneys or pancreas is termed von Hippel-Lindau (VHL) disease. Photodynamic therapy (PDT) with anti-vascular endothelial growth factor agents is an effective treatment for RCH [ 1 ], although exudative complications can occur following PDT in rare cases [ 2 , 3 , 4 ]. Herein, we present a case of massive exudative retinal detachment involving the entire retina following the administration of PDT with intravitreal injection of bevacizumab in a patient with VHL disease.…”

“…PDT for the treatment of peripheral RCH has shown effective results in terms of decreasing regional exudation from large lesions [ 1 , 5 ]. Furthermore, the complication of massive exudative retinal detachment after PDT is extremely rare; only two cases have been reported worldwide, one of which was managed by emergency vitrectomy [ 3 , 4 ]. The surgical outcomes of our case and the previous case [ 3 ] indicated successful removal of the subretinal fluid and restoration of vision.…”

“…Furthermore, the complication of massive exudative retinal detachment after PDT is extremely rare; only two cases have been reported worldwide, one of which was managed by emergency vitrectomy [ 3 , 4 ]. The surgical outcomes of our case and the previous case [ 3 ] indicated successful removal of the subretinal fluid and restoration of vision. Unlike previous cases, we also administered an intravitreal injection of bevacizumab; however, this did not prevent massive exudation following PDT.…”