Massive Exudative Retinal Detachment Following Photodynamic Therapy and Intravitreal Bevacizumab Injection in Retinal Capillary Hemangioma

Kim, Hyeong Min; Park, Kyu Hyung; Woo, Se Joon

doi:10.3341/kjo.2015.29.2.143

Cited by 13 publications

(8 citation statements)

References 5 publications

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“…Combining photodynamic therapy with intravitreal bevacizumab injections is also an effective treatment for RCH. However, there have been reports of severely decreased visual acuity caused by extensive exudative retinal detachment after that combination therapy [24].…”

Section: Clinical Results Of Retinal Capillary Hemangiomamentioning

confidence: 99%

“…Otherwise, various forms of treatment are available, including laser therapy, cryotherapy, photodynamic therapy, and vitrectomy. However, all those treatments can cause complications such as a temporary increase in the exudate or the formation of an ERM [10,24]. Therefore, treatment should be selected properly according to the patient's individual situation.…”

Section: Discussionmentioning

confidence: 99%

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Clinical Results of Various Treatments for Retinal Capillary Hemangioma

Won

Lee

Shin

et al. 2020

Korean J Ophthalmol

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We report the clinical outcomes of retinal capillary hemangioma (RCH) after the application of various treatments. Methods: We performed a retrospective chart analysis of eight eyes treated for RCH between August 2009 and January 2018. During the follow-up period, the status and progression of the RCHs were checked by fundus photography, fluorescein angiography, and optical coherence tomography, and additional treatments were applied when necessary. Results: Three of the five patients had bilateral RCH, and two had unilateral RCH. Six eyes received laser photocoagulation; two eyes received cryotherapy, and one eye received intravitreal Avastin injection. Three eyes each had intravitreal triamcinolone injection, subtenon triamcinolone injection, and intravitreal dexamethasone injection to control inflammation. Also, two patients took oral prednisolone, and one patient used prednisolone eye drops to control inflammation. Two eyes underwent vitrectomy and scleral buckling due to deterioration of the epiretinal membrane (ERM) and vitreal traction, respectively. As a result of those treatments, the tumors were stable in five of the eight eyes. However, one eye is now in a pre-phthisis state, and one patient who refused treatment showed progression of the tumor, ERM, and traction. Conclusions: Because RCHs vary in size, the degree of inflammation, and symptoms, this disorder should be actively treated on a case-by-case basis. Fluorescein angiography should be used periodically to determine recurrence of the tumor or inflammation, and the appropriate treatment should be repeated as necessary. Moreover, regular systemic screening tests for von Hippel-Lindau disease should be performed in RCH patients to ensure that they have no abnormalities other than in the eye.

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Section: Clinical Results Of Retinal Capillary Hemangiomamentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Clinical Results of Various Treatments for Retinal Capillary Hemangioma

Won

Lee

Shin

et al. 2020

Korean J Ophthalmol

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“…33,34,37 It has been reported to occur in the setting of chronic CSCR, choroidal hemangioma, retinal capillary hemangioma, CNVM, nAMD, and PCV with the highest incidence reported in CSCR (30.4%) followed by PCV (8.45%) and nAMD (6.67%). 17,[30][31][32][33][34]36 In a 2020 report, Manayath et al described the risk factors for PAEM in a large cohort of 177 PDT treatments in 155 eyes. These include age over 65 years, PCV, spot size >3.5 mm, pre-treatment best corrected visual acuity (BCVA) 20/40 or better, first time treatment and reduced-fluence PDT.…”

Section: Prevalence and Disease Characteristicsmentioning

confidence: 99%

“…[12][13][14] PDT has demonstrated efficacy in the treatment of a variety of conditions including CSCR, polypoidal choroidal vasculopathy (PCV), nAMD, choroidal hemangioma, retinal capillary hemangioma, and CNVM related to pathologic myopia. 1,11,[14][15][16][17] In particular, the use of PDT in the treatment of PCV has been the subject of intense scrutiny over the last decade as this condition's prevalence across demographic groups and misidentification as typical nAMD were increasingly recognized. [18][19][20][21] The LAPTOP study showed superior visual outcomes using intravitreal ranibizumab given monthly for 3 months followed by pro re nata (PRN) dosing compared with PDT treatments alone in patients with PCV.…”

Section: Introductionmentioning

confidence: 99%

Photodynamic Therapy-Induced Acute Exudative Maculopathy (PAEM): Prevalence, Impact and Management Strategies

Sumnicht¹,

Chalam²,

Sierpina³

2022

OPTH

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Photodynamic therapy (PDT) has a niche role in treating various choroidal pathologies. PDT-induced acute exudative maculopathy (PAEM) is an uncommon complication of PDT that results in exudative retinal detachment and mild to severe decrease in vision. Successful management strategies include observation, local or systemic corticosteroids, and intravitreal anti-vascular endothelial growth factor (anti-VEGF) injections. Most cases return to visual acuity near baseline. This review summarizes what is known about PAEM to date including etiology, prevalence, management strategies, and outcomes. We conclude that management of PAEM must take into consideration various patient-specific factors. Treatment with corticosteroids or anti-VEGF agents may expedite time to recovery, though lack of randomized controlled trials preclude firm conclusions regarding a standardized approach to managing this complication of PDT.

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“…; Kim et al. ), have been reported, as well as surgery combined with PDT (Mariotti et al. ) or radiotherapy (Irvine et al.…”

Section: Introductionmentioning

confidence: 99%

Early surgical treatment of retinal hemangioblastomas

Overdam

Missotten

Kılıç

et al. 2016

Acta Ophthalmologica

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ABSTRACT.Purpose: To evaluate the clinical course after early surgical treatment with excision of retinal hemangioblastomas (RHs) before development of major complications. Methods: Interventional case series of four eyes (four patients) with a peripheral RH that had not yet been treated by laser or cryotherapy prior to surgery. All eyes underwent 23-gauge vitrectomy with lesion excision. One patient underwent ligation of the feeder vessel prior to lesion excision. Best-corrected visual acuity and clinical course were assessed during a follow-up period of at least 4 years. Results: Four patients (mean age 27.3 years; range 19-32) were included, of whom two had von Hippel-Lindau syndrome. Visual acuity improved in three patients (mean 4.8 lines; range 3-10) and remained stable at 0.0 logMAR in one patient. There were no intraoperative complications. Postoperative complications included transient mild vitreous haemorrhage (n = 2), and local epiretinal membrane formation at the excision location (n = 1). At 4 years postoperatively, there were no long-term complications. There was one case of a new lesion, which was effectively treated with laser. Conclusion: Vitrectomy with RH excision seems to be an effective approach for larger RHs and could be considered an early treatment option in selected cases. Postoperative complications were limited in scope of this case series. Important points to consider during vitrectomy are effective closure of feeder and draining vessels as well as complete removal of posterior hyaloid and epiretinal membranes in order to avoid postoperative vitreous haemorrhage and proliferative vitreoretinopathy.

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Massive Exudative Retinal Detachment Following Photodynamic Therapy and Intravitreal Bevacizumab Injection in Retinal Capillary Hemangioma

Cited by 13 publications

References 5 publications

Clinical Results of Various Treatments for Retinal Capillary Hemangioma

Clinical Results of Various Treatments for Retinal Capillary Hemangioma

Photodynamic Therapy-Induced Acute Exudative Maculopathy (PAEM): Prevalence, Impact and Management Strategies

Early surgical treatment of retinal hemangioblastomas

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