Massive Osteolysis (Acute Spontaneous Absorption of Bone, Phantom Bone, Disappearing Bone)

Gorham, L. W.; Stout, Arthur Purdy

doi:10.2106/00004623-195537050-00008

Cited by 568 publications

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“…Neovascularization and synovitis, as found in massive unicentric osteolysis (Gorham's disease), were not present (22,23). Reparative changes in osseous tissue were present as evidenced by woven bone formation.…”

Section: Discussionmentioning

confidence: 97%

Idiopathic Multicentric Osteolysis

Whyte

Murphy

Kleerekoper

et al. 1978

Arthritis & Rheumatism

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Genetic, rheumatologic, immunologic, metabolic, and renal studies of a father and son with idiopathic multicentric osteolysis are reported. The disorder appeared through mutation. The father developed symptoms as an infant, his son at age 4 years and 9 months. Both have micrognathia and hypotelorism and were exceptionally tall during the symptomatic phase of their disease. Biopsies of the son's wrist showed normal synovium, encroachment on cartilage by fibrocellular tissue, and both osteoclastic resorption and repair of affected bone. Hydroxyproline in his urine was increased. No immunologic, renal, or other metabolic abnormalities were identified. Idiopathic multicentric osteolysis (IMO) is the name chosen by Tyler and Rosenbaum ( I ) in 1976 for a rare disorder characterized by multifocal articular bone destruction beginning in infancy or childhood. Typically, pain and swelling of the wrists and ankles begin after an episode of trauma, persist during childhood, and then remit during adolescence leaving variable deformity of the hands and feet. Since the carpal and tarsal bones are invariably affected, this disease had previously been called "carpal and tarsal osteolysis" (2,3) or "disappearing carpal bones" (4). Little is known about its pathogenesis, hence, some chose to describe it as "essential" ( S I I ) , whereas others emphasized that the disorder in some cases was hereditary (12-14) or occasionally associated with fatal nephropathy (6,8,11,13,15). Recent and comprehensive reviews have been published (1,2,7,12). Our purpose is to describe the results of clinical, genetic, and laboratory studies of a family in which dominant transmission of IMO followed its appearance through mutation. FAMILY DESCRIPTIONCase 1 (Figure 1, 111-1) An 8% year old boy was the product of a normal first pregnancy and delivery. H e was well until age 4% when he injured his left elbow. Although clinical examination did n o t indicate trauma, radiographs reportedly disclosed a "hairline"

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Section: Discussionmentioning

confidence: 97%

Idiopathic Multicentric Osteolysis

Whyte

Murphy

Kleerekoper

et al. 1978

Arthritis & Rheumatism

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“…Only 28 cases, to our knowledge, have been reported in the English literature (Table 1) (Bickel and Broders 1947;Gorham and Stout 1955;Falkmer and Tilling 1956;Hambach et al 1958;Castleman and McNeely 1964;Ellis and Adams 1971;Thompson and Schurman 1974;Heyden et al 1977;Woodward et al 1981;Heffez et al 1983;Brown et al 1986;Bohlman et al 1986;Hejgaard and Olsen 1987;Joseph and Bartal 1987;Mitchell et al 1993;Drewry et al 1994;Halliday et al 1994;Stöve and Reichelt 1995;Aoki et al 1996;Livesley et al 1996;Chung et al 1997;Hagberg et al 1997;Mawk et al 1997;Benhalima et al 2001;Bode-Lesniewska et al 2002;Chong and Shell 2003;Ceroni et al 2004). Eighteen patients were males and 10 patients were females.…”

Section: Discussionmentioning

confidence: 99%

“…Since first described by Jackson (1838), it was called by various names: vanishing bone disease, acute absorption of bone, phantom bone, primary lymphangioma, progressive osteolysis and disappearing bone (Gorham and Stout 1955). Gorham and Stout tabulated 24 previously reported cases in 1955 and the condition became known as Gorham disease thereafter.…”

confidence: 99%

Gorham Disease of the Spine: A Case Report and Treatment Strategies for This Enigmatic Bone Disease

Aizawa

Sato

Kokubun

2005

Tohoku J. Exp. Med.

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“…An aneurysmal bone cyst most often affects persons under the age of 20 years and comprises cavities full of sero-haematic liquid; monostotic bone localisation is usual [4,7]. The rare Gorham-Stout syndrome, also termed ''idiopathic osteolysis'', was excluded because of the patient's age (over 30 years) and presence of the hip prosthesis, together with the macroscopic and histological findings [9,11].…”

Section: Discussionmentioning

confidence: 99%

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty

Jeanrot

Ouaknine

Anract

et al. 1999

International Orthopaedics

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A 51 year-old man developed an extensive osteolytic response to wear debris in an uncemented porous-coated total hip arthroplasty, with metal/polyethylene interface, which had been implanted eighteen years previously. This reaction, which involved the upper femur and the ilium, produced a mass which compressed the pelvic viscera. IntroductionOsteolysis is a frequent complication which affects the outcome of total hip arthroplasty. Since Charnley's first description concerning a cemented prosthesis in 1968 [5], osteolysis has been described as occurring around loose and well-fixed femoral and acetabular implants of cemented and cementless prostheses. This complication results from an inflammatory foreign body reaction to the different prosthetic components and wear debris from the articulating surfaces and the interfaces has been implicated as a causative factor [1]. Polymethylmethacrylate cement, polyethylene, metal and more recently ceramic [27] debris may be the cause of osteolytic response, although polyethylene debris is considered to be the most damaging. Phagocytosis of debris by macrophages releases the mediators of osteolysis. Lack of bone ingrowth in uncemented implants or defective fixation at the bone-cement interface in cemented prostheses play a role in producing particles and activating the reaction [1,10,27]. Once radiologically identified, the majority of the osteolytic lesions remain stable over many years or else evolve slowly [15,18,25,26,28]. A minority progress, mimicking a tumour [3, 10, 12-14, 17, 19-21, 27]. These massive osteolyses constitute a real clinical problem, because of the eventual failure of the implant and technical difficulties at revision due to bone loss. We report an unusual case of an aggressive pelvic and femoral osteolysis secondary to an uncemented hip prosthesis which had been implanted eighteen years previously. Case reportIn March 1995, a black male aged 51 years was admitted into our Department of Orthopaedic Surgery with pain and swelling affecting the proximal third of the left thigh. He had the sequelae of neonatal cerebral palsy (Little's syndrome) and had started to walk with an aid at the age of seven years. In December 1977, at the age of 34 years, he was treated in another hospital for a femoral neck non-union which occurred two years after a femoral neck fracture. Replacement arthroplasty was undertaken using an uncemented

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Massive Osteolysis (Acute Spontaneous Absorption of Bone, Phantom Bone, Disappearing Bone)

Cited by 568 publications

References 0 publications

Idiopathic Multicentric Osteolysis

Idiopathic Multicentric Osteolysis

Gorham Disease of the Spine: A Case Report and Treatment Strategies for This Enigmatic Bone Disease

Massive pelvic and femoral pseudotumoral osteolysis secondary to an uncemented total hip arthroplasty

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