Massive Thrombosis Produced by Fatty Acid Infusion*

Nonesterified Fatty Acids, Albumin, and Platelet Aggregation

“…Thus, the infusion of NEFAs leads to massive thrombosis and platelet activation (1)(2)(3)(4). It has also been shown that their binding to albumin protects the platelets from activation (5).…”

Polyunsaturated fatty acids, hyperlipidemia, and thrombosis.

“…9 " 11 Only recently, with the discovery of platelet and vessel wall prostaglandins, has a more precise mechanism of how dietary fatty acids might affect thrombosis been elucidated. 4 Twenty-carbon fatty acids of both the co-6 and co-3 families serve as substrates for the synthesis of different prostaglandins having diverse activities.…”

Free fatty acids in the pancreatitic arthritis syndrome

“…Unbound free fatty acids and lysophospholipids possess marked phlogistic properties (17,18). Binding to albumin, however, blocks these effects at normal serum concentrations.…”