2024
DOI: 10.1101/2024.07.24.604935
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Massively parallel genetic perturbation reveals the energetic architecture of an amyloid beta nucleation reaction

Anna Arutyunyan,
Mireia Seuma,
Andre J. Faure
et al.

Abstract: Amyloid protein aggregates are pathological hallmarks of more than fifty human diseases including the most common neurodegenerative disorders. The atomic structures of amyloid fibrils have now been determined, but the process by which soluble proteins nucleate to form amyloids remains poorly characterised and difficult to study, even though this is the key step to understand to prevent the formation and spread of aggregates. Here we use massively parallel combinatorial mutagenesis, a kinetic selection assay, a… Show more

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