Mast cell density and IL‐8 expression in nonlesional and lesional psoriatic skin

Jiang, Wanling; Chattedee, Arka D.; Raychaudhuri, S. P.; Raychaudhuri, Smriti K.; Farber, Eugene M.

doi:10.1046/j.1365-4362.2001.01262.x

Cited by 77 publications

(66 citation statements)

References 27 publications

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“…9,[18][19][20][21] It is histo pat ho lo gi cally cha rac te ri zed by pa ra ke ra to sis, Turkiye Klinikleri J Med Sci 2011;31 (2) hyper ke ra to sis, re gu lar acant ho sis, elon ga ti on of the epi der mal re te rid ges, elon ga ti on and ede ma of the der mal pa pil la e, and lymphocy tic cell in fil tra tion. 11,[21][22][23] This was al so con fir med in our study. Psori a sis usu ally runs a chro nic co ur se alt ho ugh spon tane o us or tre at ment-in du ced re mis si ons may oc cur.…”

Section: Discussionsupporting

confidence: 59%

“…Tre at ment re gi mens for psori a sis are known to subs tan ti ally re du ce mast cell num bers at le si o nal si tes as the reg res sed pla qu es. 10,11 This was al so ob ser ved in our study. The re was a par ti al re duc ti on of mast cell num bers at the si te of reg res sed pso ri a tic le si ons.…”

supporting

confidence: 64%

“…1,3,[11][12][13]21 The se in di ca te a po ten ti al ini ti a tor ro le of mast cells in the pat ho ge ne sis of pso ri a sis. 1,13 Mast cell-me di a ted vascu lar al te ra ti on is sug ges ted to play a ro le in the deve lop ment of pso ri a sis.…”

Section: Control Groupunclassified

“…Der mal in fil tra te of the pso ri a sis con sists lympho mo no nuc le ar cells and mast cells. 1,7,[11][12][13] Re cent stu di es ha ve shown that mast cells may play a ro le in the pat ho ge ne sis of pso ri asis.…”

mentioning

confidence: 99%

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Mast Cells and p53 Expression in Psoriasis Vulgaris

Barut¹,

Bektaş²,

Gün³

et al. 2011

Turkiye Klinikleri J Med Sci

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A AB BS S T TR RA AC CT T O Ob b j je ec c t ti i v ve e: : Pso ri a sis vul ga ris is a chro nic inf lam ma tory T-cell me di a ted im mu ne derma to sis cha rac te ri zed by a high epi der mal cell tur no ver, which re sults in a typi cal epi der mal hyperp la si a. The aim of this study is to show the cor re la ti on bet we en p53 pro te in ac cu mu la ti on that pro vi des epi der mal hyper pro li fe ra ti on and mast cell co unt in the pat ho ge ne sis of pso ri a sis vul garis. M Ma a t te e r ri i a al l a an nd d M Me et t h ho od ds s: : In this study, punch bi op si es from 56 pso ri a sis ca ses ha ve be en eva lua ted. The pre sen ce of mast cells in with me tac hro ma tic gra nu les are with 1% to lu i din blu e sta in so lu ti on has be en in ves ti ga ted. In ad di ti on, mast cells that show im mu no re ac ti ons to "mast cell trypta se " an ti body ha ve be en ob ser ved and pro por ti on of p53 sta i ning in epi der mal ke ra ti nocy tes has be en de ter mi ned. R Re e s su ul lt ts s: : In pso ri a sis ca ses, mast cells co unt (me an) and pro por ti on of p53 stai ning (me an) were 69.3 ± 21.5/mm 2 and 602.3 ± 192.1 respectively, in the gro up wit ho ut any treat ment (n: 20); 57.1 ± 27.5/mm 2 and 373.1 ± 193.6 respectively in the gro up tre a ted with pso la ren plus UVA ra di a ti on (n: 36). In the con trol gro up, it was de mons tra ted that mast cells co unt was 74.6 ± 25.9/mm 2 (me an) and pro por ti on of p53 sta i ning was 176.4 ± 109.2 (me an). No cor re la ti on has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in pso ri a sis gro ups. Ho we ver, a mo de ra te cor re la ti on (r= 0.30 P< 0.05) has be en fo und bet we en mast cell co unt and pro por ti on of p53 sta i ning in the con trol gro up. C Co on nc c l lu u s si i o on n: : Sin ce the cor re la ti on ob ta i ned bet we en mast cell num ber and pro por ti on of p53 sta i ning in the he althy skin was not observed pso ri a sis ca ses, it can be tho ught that the se va ri ab les ta ke part in different pathways of pathogenesis.K Ke ey y W Wo or rd ds s: : Pso ri a sis; mast cells; p53 pro te in (325-355) Ö ÖZ ZE ET T A Am ma aç ç: : Pso ri a zis vul ga ris, yük sek epi der mal hüc re yı kı mı ile ka rak te ri ze, ti pik epi der mal hiperp la zi ile so nuç la nan kro nik inf la ma tu ar T hüc re ba ğım lı bir der ma toz dur. Bu ça lış ma nın ama cı, pso ri a zis vul ga ris pa to ge ne zin de yer alan mast hüc re sa yı sı ile epi der mal hi per pro li fe ras yo nu sağ -la yan p53 pro te in bi ri ki mi ara sın da ki ko re las yo nu gös ter mek tir. G Ge e r re eç ç v ve e Y Yö ön n t te em m l le er r: : Bu ça lış mada 56 pso ri a zis vul ga ris va ka sı na ait punch bi yop si ma ter ya li de ğer len di ril miş tir. Yüzde birlik to lu i din ma vi si ile bo ya nan me tak ro ma tik gra nül ler içe ren mast hüc re le rin var lı ğı araş tı rıl mış tır. İla ve ola rak, mast hüc re trip taz an ti ko ru ile re ak si yon ve ren mast hüc re le ri in ce len miş ve epi dermal ke ra ti no sit ler de ki p53 bo yan...

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Section: Discussionsupporting

confidence: 59%

supporting

confidence: 64%

Section: Control Groupunclassified

mentioning

confidence: 99%

See 2 more Smart Citations

Mast Cells and p53 Expression in Psoriasis Vulgaris

Barut¹,

Bektaş²,

Gün³

et al. 2011

Turkiye Klinikleri J Med Sci

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“…relevance in human diseases, because large numbers of activated mast cells infiltrate tissue in the corresponding human diseases, such as allergic contact dermatitis, psoriasis, or RA (5)(6)(7)(8)(9)(10). However, the relative contribution of local mast cells to the initiation of these diseases is enigmatic.…”

mentioning

confidence: 99%

Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice

Kneilling

Hültner

Pichler

et al. 2007

Arthritis & Rheumatism

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Objective. Induction of arthritis with autoantibodies against glucose-6-phosphate isomerase (GPI) is entirely independent of T cells and B cells but isResults. Comparing wild-type mice, mast celldeficient Kit W /Kit W-v mice, and mast cell-reconstituted Kit W /Kit W-v mice, we first showed that intraarticular and intraperitoneal mast cell engraftment fully restores susceptibility to antibody-induced arthritis, angiogenesis, and ␣v␤3 integrin activation. Importantly, selective mast cell silencing with either salbutamol or cromolyn prevented ␣v␤3 integrin activation, angiogenesis, and joint destruction.Conclusion. Mast cell engraftment fully restores susceptibility to ␣v␤3 integrin activation, angiogenesis, and joint destruction in GPI antibody-induced arthritis. Importantly, selective mast cell stabilization prevents ␣v␤3 integrin activation, angiogenesis, and joint destruction.

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An Ultraswelling Microneedle Device for Facile and Efficient Drug Loading and Transdermal Delivery

Li,

Zhao,

Ling

et al. 2023

Adv Healthcare Materials

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The advancement and extensive demand for transdermal therapies could benefit from a safe, and efficient and user‐friendly transdermal technology with broad applicability in delivering various hydrophilic drugs. Here we report the design and proof of concept applications of an ultra‐swelling microneedle device that enables the facile and efficient loading and transdermal delivery of hydrophilic drugs with different molecular weights. The device consists of a super‐hydrophilic hydrogel microneedle array and a resin base substrate. Using a special micromoulding technique that involves hydrated crosslinking and cryogenic‐demoulding, the microneedle part displays a rapid swelling ratio of approximately 3800%, enabling the loading of drugs up to 500 kDa in molecular weight. The drug loading process using the device just involves incubating the microneedle part in a drug solution for 1 min, followed by 15 min of drying. The microneedles can easily penetrate the skin under press and detach from the base substrate under shear, thereby releasing the payload. Administration of desired therapeutic agents using the device outperformed conventional administration methods in mitigating psoriasis and eliciting immunity. This biocompatible device, capable of withstanding ethylene oxide sterilization, could enhance the efficacy and accessibility of transdermal therapies in research institutes, hospitals, and even home settingsThis article is protected by copyright. All rights reserved

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Mast cell density and IL‐8 expression in nonlesional and lesional psoriatic skin

Abstract: The results of this study suggest that increased levels of IL-8 in the keratinocytes of psoriatic plaques play a contributing role in the migration of mast cells to lesion sites.

Cited by 77 publications

References 27 publications

Mast Cells and p53 Expression in Psoriasis Vulgaris

Mast Cells and p53 Expression in Psoriasis Vulgaris

Targeted mast cell silencing protects against joint destruction and angiogenesis in experimental arthritis in mice

An Ultraswelling Microneedle Device for Facile and Efficient Drug Loading and Transdermal Delivery

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