Mast cell–derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice

Nakae, Susumu; Ho, Lien H.; Yu, Mang; Monteforte, Rossella; Iikura, Motoyasu; Suto, Hajime; Galli, Stephen J.

doi:10.1016/j.jaci.2007.02.046

Cited by 166 publications

(155 citation statements)

References 56 publications

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“…Some of the positive immunomodulatory functions of mast cells that have been proposed based on in vitro studies have been confirmed in vivo using mast cell knock-in mice 1,54,[57][58][59][60][61][62][63][64][65][66][67][68][69][70] or in mice lacking specific mast-cell-associated proteases [26][27][28][32][33][34] or lacking specific protease enzymatic activity 11 (Table 1 ). In many of these studies, the end points assessed included the recruitment of particular immune cells, such as granulocytes 28,32,33,[57][58][59][60][61]63,64,[67][68][69][70] , DCs 62,64,65,71 or various subpopulations of lymphocytes 64,67,70,72 .…”

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 93%

“…In many of these studies, the end points assessed included the recruitment of particular immune cells, such as granulocytes 28,32,33,[57][58][59][60][61]63,64,[67][68][69][70] , DCs 62,64,65,71 or various subpopulations of lymphocytes 64,67,70,72 . Many of these studies also demonstrated that the lack of mast cells 54,[57][58][59][60][61][62][63][64]67,69,70 or a specific mast-cell product 28,32,33,54,60,63,67,68,70 also reduced the pathology associated with the immune response or impaired its effectiveness in promoting host resistance to infection.…”

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

“…Mast-cell-derived TNF contributes to airway hyperreactivity and inflammation in models of allergic airway inflammation 67,70,79 , probably in part due to its ability to promote T-cell recruitment 67,70 and to enhance local levels of IL-4, IL-5, IL-13 and IL-17 (Ref. 67 ).…”

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

“…67 ). Mast cells also can contribute substantially to the disease pathology in models of autoantibody-induced destructive arthritis 80 , bullous pemphigoid (an autoimmune disease of the skin) 81 and in a model of T H 17-cell-dependent, neutrophil-associated lung inflammation 68 .…”

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

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Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008

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Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 93%

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

Section: Positive Immunomodulatory Functions In Vivomentioning

confidence: 99%

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Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

2008

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“…E1 in Ref. 20). Ship1 ϩ/ϩ -BMMC mice had slightly reduced number of infiltrating BAL cells compared with Kit W-sh/W-sh mice, highlighting the importance of wild-type reconstituted controls.…”

Section: Allergic Airway Inflammation Is Greater In Ship1 ϫ/ϫ -Bmmc Mmentioning

confidence: 94%

SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo

Haddon

Antignano

Hughes

et al. 2009

The Journal of Immunology

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SHIP1 inhibits immune receptor signaling through hydrolysis of the PI3K product phosphatidylinositol 3,4,5-trisphosphate, forming phosphatidylinositol 3,4-bisphosphate. In mast cells, SHIP1 represses FcεRI- and cytokine-mediated activation in vitro, but little is known regarding the function of SHIP1 in mast cells in vivo or the susceptibility of Ship1−/− mice to mast cell-associated diseases. In this study, we found that Ship1−/− mice have systemic mast cell hyperplasia, increased serum levels of IL-6, TNF, and IL-5, and heightened anaphylactic response. Further, by reconstituting mast cell-deficient mice with Ship1+/+ or Ship1−/− mast cells, we found that the above defects were due to loss of SHIP1 in mast cells. Additionally, we found that mice reconstituted with Ship1−/− mast cells suffered worse allergic asthma pathology than those reconstituted with Ship1+/+ mast cells. In summary, our data show that SHIP1 represses allergic inflammation and mast cell hyperplasia in vivo and exerts these effects specifically in mast cells.

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Umbilical Cord Derived Mast Cells as Models for the Study of Inflammatory Diseases

Kourelis¹,

Kempuraj²,

Manola³

et al. 2009

Perinatal Stem Cells

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Mast cell–derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice

Cited by 166 publications

References 56 publications

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

Immunomodulatory mast cells: negative, as well as positive, regulators of immunity

SHIP1 Is a Repressor of Mast Cell Hyperplasia, Cytokine Production, and Allergic Inflammation In Vivo

Umbilical Cord Derived Mast Cells as Models for the Study of Inflammatory Diseases

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