Mast Cell-Eosinophil Cross-Talk Regulates Function and Viability of Both Cells in Vitro

Elishmereni, Moran; Ben-Efraim, A. H. Nissim; Bachelet, Ido; Levi-Schaffer, F.

doi:10.1016/j.jaci.2007.12.438

Cited by 1 publication

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“…In these instances, NK cell activity improved and even returned to normal as a result of the vitamin D supplementation [ 20 ]. Studies have identified novel MC-derived molecules, in either a secreted or membrane-bound form, facilitate communication between various immune cells [ 21 ], such as T cells [ 22 ], B cells [ 23 ], NK cells [ 24 ], innate lymphoid cells [ 25 ], eosinophils [ 26 ], MQs [ 27 ], and DCs [ 28 ]. The impact of vitamin D levels on these intercellular interactions is currently unknown and requires further research.…”

Section: Vitamin D and Immunomodulationmentioning

confidence: 99%

“…During viral infections, B cells play a crucial role in secreting IgG antibodies specific to viral antigens. These IgGs then bind to the MCs through their Fc region, triggering MC activation [ 26 ]. It has been suggested that vitamin D inhibits the maturation and switching of B-lymphocytes [ 77 ].…”

Section: Vitamin D Affects Mcs In Fighting Viral Infection and Viral ...mentioning

confidence: 99%

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Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Mehrani,

Morovati,

Tieu

et al. 2023

Cells

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Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses.

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Section: Vitamin D and Immunomodulationmentioning

confidence: 99%

Section: Vitamin D Affects Mcs In Fighting Viral Infection and Viral ...mentioning

confidence: 99%

Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Mehrani,

Morovati,

Tieu

et al. 2023

Cells

View full text Add to dashboard Cite

show abstract

Mast Cell-Eosinophil Cross-Talk Regulates Function and Viability of Both Cells in Vitro

Cited by 1 publication

References 0 publications

Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

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