Mast cell reactivity at the margin of human skin wounds: An early cell marker of wound survival?

Oehmichen, M.; Gronki, T.; Meißner, Christoph; Anlauf, Manfred; Schwark, Thorsten

doi:10.1016/j.forsciint.2009.05.020

Cited by 34 publications

(23 citation statements)

References 21 publications

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“…They are predominantly found in the dermis near to the vascular tissue, the basement membrane of endothelial cells and nerves 8 . They exhibit cytoplasmic granules containing histamine, serotonin, tryptase and various cytokines -tumor necrosis factor, interleukin-4, fibroblast growth factors and epithelial growth factors-are able to stimulate the proliferation of endothelial with topic application of 2% chlorhexidine.…”

Section: ■ Introductionmentioning

confidence: 99%

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Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

et al. 2017

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Purpose: To evaluate wound contraction and the concentration of mast cells in skin wounds treated with wild plum (Ximenia americana) essential oil-based ointment in rats. Methods: Sixty rats were submitted to two cutaneous wounds in the thoracic region, on the right and left antimeres. Thereon, they were divided into three groups: GX (wounds treated once a day with hydro alcoholic branch extract of Ximenia amerIcana), GP (wounds that received vehicle), and GC (wounds without product ap-plication). Wounds were measured immediately after the injury as well as 4, 7, 14 and 21 days post-topical application of the extract. At these days, five rats from each group were euthanatized. Thereafter, samples were fixed in 10% formalde-hyde and processed for paraffin embedding. Sections were stained with H.E, Masson's Trichrome and toluidine blue for morphological, morphometrical and histopathological analysis, under light microscopy. The degree of epithelial con-traction was measured and mast cell concentrations were also evaluated with an image analyzer (Image Pro-plus®software). Results: The extract treated group showed lower mast cell concentrations in the 4th day of lesion, as compared to GP (GX GP = GC; p<0.05). Conclusion: Ointment containing 10% X. americana induces a decrease in mast cell concen-tration, at the beginning of the healing process, and promotes early skin wound contraction in rats.

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Section: ■ Introductionmentioning

confidence: 99%

“…cells, epithelial and fibroblasts 8 . They have the function of helping the immune defense mechanism, acting as body guards, being involved in inflammatory and hypersensitivity reactions and local immune responses 9 .…”

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confidence: 99%

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

et al. 2017

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“…They are predominantly found in the dermis, near the vascular tissue and the basement membrane of endothelial cells and nerves 3 .…”

Section: Introductionmentioning

confidence: 99%

“…These cells present cytoplasmic granules that contain histamine, serotonin, tryptase and several cytokines (tumour necrosis factor, interleukin-4, fibroblast growth factors and epithelial cells), which are capable of stimulating the proliferation of endothelial and epithelial cells and fibroblasts 3 . When the inflammatory phase begins, these cells release several vasoactive mediators, which cause an increase in vascular permeability and oedema 4 .…”

Section: Introductionmentioning

confidence: 99%

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Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

et al. 2015

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PURPOSE:To evaluate wound contraction and the concentration of mast cells in skin wounds treated with 5% BPT essential oil-based ointment in rats. METHODS:Twenty rats, male, of adult age, were submitted to skin surgery on the right (RA) and left antimeres (LA) of the thoracic region. They were divided into two groups: control (RA -wounds receiving daily topical application of vaseline and lanolin) and treated (LA -wounds treated daily with the topical ointment). The skin region with wounds were collected at days 4, 7, 14 and 21 after surgery.Those were fixed in 10% formaldehyde and later processed for paraffin embedding. Sections were obtained and stained by H.E for histopathology analysis. The degree of epithelial contraction was measured and mast cell concentration were also evaluated. RESULTS:The treated group showed higher mast cell concentrations (p<0.05) associated with increased contraction at day 7 and 14 respectively. CONCLUSION:Ointment containing 5% Brazilian pepper tree oil increases mast cell concentration and promotes skin wound contraction in rats.

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Vitality, Injury Age, Determination of Skin Wound Age, and Fracture Age

Dettmeyer¹

2018

Forensic Histopathology

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Mast cell reactivity at the margin of human skin wounds: An early cell marker of wound survival?

Cited by 34 publications

References 21 publications

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

Mast cell concentration and skin wound contraction in rats treated with Ximenia americana L

Mast cell concentration and skin wound contraction in rats treated with Brazilian pepper essential oil (Schinus terebinthifolius Raddi)

Vitality, Injury Age, Determination of Skin Wound Age, and Fracture Age

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