Mast-cell stabilising agents to prevent exercise-induced bronchoconstriction

The emerging role of transient receptor potential channels in chronic lung disease

“…mannitol) provoke bronchoconstriction and cough in asthmatics via activation of sensory nerves [71]. Consistent with a neuronal mechanism, anticholinergics produce significant protection from exercise-induced bronchospasm [72]. With nonallergic triggers we propose that the agent would directly stimulate nerves, via TRP channels, to induce bronchospasm/LAR/cough in a steroid-resistant manner, explaining the relative treatment-resistant phenotype associated with nonallergic, non-T-helper cell type 2 asthma (figure 1).…”

The prevention of exercise-induced bronchoconstriction: what are the options?

“…Sodium cromoglycate (Intal TM , sanofi-aventis, Paris, France) and nedocromil sodium (Tilade TM , sanofi-aventis) are other drugs with an indication for EIB [12]. These drugs are immediately effective against EIB even when used for the first time.…”

Lungensport bei asthmakranken Erwachsenen

“…Wichtigster Baustein ist das inhalierbare Kortikosteroid. Die Inhalation von β 2 -Sympathomimetika kann das EIA nahezu vollständig blocken, weniger wirksam sind Mastzellstabilisatoren und Anticholinergika [10,11]. Eine nachgewiesene Wirkung auf das Anstrengungsasthma (engl.…”