Mast Cell Tumors

Kiupel, Matti

doi:10.1002/9781119181200.ch6

Cited by 37 publications

(88 citation statements)

References 134 publications

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“…MCTs can be located in the epidermis or outer dermis when they are classified as cutaneous MCT, or below these anatomic structures when they are subcutaneous MCTs (Kiupel, 2017). While subcutaneous MCTs can often be completely surrounded by fatty tissue, this case was a rare occurrence of MCT within a lipoma in an 11-yearold female white toy poodle.…”

Section: Discussionmentioning

confidence: 86%

Mast cell tumor within a lipoma in a white toy poodle

et al. 2018

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Section: Discussionmentioning

confidence: 86%

Mast cell tumor within a lipoma in a white toy poodle

et al. 2018

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“…The different patterns of margin length reduction between MCT and STS may partially be explained by biologic differences between the 2 tumor types. For example, MCT are often associated with collagenolysis, sclerosis, edema, necrosis, and secondary lymphocytic inflammation . They have been proposed to possess a “reactive halo” of edema fluid, inflammatory cells, mast cells, and reactive stromal cells surrounding newly formed capillaries and may release vasoactive substances (eg, histamine) .…”

Section: Discussionmentioning

confidence: 99%

“…One of the primary limitations in the present report is the lack of high‐grade tumors in the study population. Changes in the reactive zone of the tumor, including microscopic infiltration with neoplastic cells, could be more pronounced with high‐grade MCT and/or STS . This study was intentionally designed to exclude this subset of tumors, to facilitate comparisons among a more homogenous tumor population.…”

Section: Discussionmentioning

confidence: 99%

“…[23][24][25] They have been proposed to possess a "reactive halo" of edema fluid, inflammatory cells, mast cells, and reactive stromal cells surrounding newly formed capillaries and may release vasoactive substances (eg, histamine). 25 Manipulation during surgical resection could influence the formation of peritumoral edema and/or inflammation. In contrast, the periphery of STS frequently consists of a F IGUR E 2 Reduction in circumferential lengths of surgical margins from 50 canine mast cell tumors (177 margin measurement sets) at 4 specific processing steps from surgical excision to histopathologic evaluation.…”

mentioning

confidence: 99%

“…Changes in the reactive zone of the tumor, including microscopic infiltration with neoplastic cells, could be more pronounced with high-grade MCT and/or STS. 13,20,[24][25][26] This study was intentionally designed to exclude this subset of tumors, to facilitate comparisons among a more homogenous tumor population. Stromal alterations in high grade tumors could influence the physical reduction in surgical margin length, by affecting response to formalin fixation, alcohol dehydration, paraffin embedding, and other processing steps for histopathology.…”

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confidence: 99%

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Reductions in margin length after excision of grade II mast cell tumors and grade I and II soft tissue sarcomas in dogs

et al. 2017

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Objective: Quantify changes in the circumferential lengths of surgical margins of resected canine mast cell tumors (MCT) and soft tissue sarcomas (STS) between the time of collection and histopathology.Study design: Prospective, hypothesis-driven, clinical study.Sample population: Two hundred and thirty-seven margins from 69 excised tumors (50 MCT and 19 STS) in 51 client-owned dogs. Methods:The lengths of surgical margins were recorded (eg, cranial, caudal, dorsal, and ventral) for each tumor at 5 time points: intraoperatively (in vivo), immediately after excision (ex vivo), after formalin fixation (postfixation), once mounted on glass slides (subgross), and as histologically tumor-free margins (HTFMs).Results: Compared to in vivo dimensions, the length of surgical margins at each processing step (ie, ex vivo, postfixation, subgross, and HTFM) was reduced by a median of 3.0, 5.0, 6.0, and 8.8 mm for MCT; 2.5, 2.0, 5.0, and 5.0 mm for STS. All processing steps resulted in significant reductions among MCT samples (P < .0001), except between postfixation vs subgross, and for STS samples (P < .0001), except between ex vivo vs postfixation and subgross vs HTFM. The maximum reduction in the total length of margins (from in vivo to HTFM) was 29.6 and 24.2 mm for MCT and STS, respectively.Conclusion: Surgical margin length reductions occur due to a combination of physical factors (eg, tissue elasticity, myofibril contraction, and histologic processing) and biological factors (eg, microscopic tumor infiltration into the grossly normal surgical margin).Clinical significance: These data provide information relevant to evidence-based surgical planning and may influence patient morbidity in the most commonly encountered cutaneous malignancies of dogs.

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Canine mast cell tumours part I: Clinical and survival outcomes

Tamlin

Bottema

Woolford

et al. 2022

Veterinary Medicine & Sci

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Background Dogs have a species‐specific susceptibility for developing mast cell tumours (MCTs). Mutations in the KIT proto‐oncogene (KIT) are known to contribute to the neoplastic biology of mast cells. In dogs, the most common KIT mutation is an internal tandem duplication (ITD) in exon 11 which has been considered a useful prognostic supplement to traditional histopathological tumour grading. Objective The aim of this retrospective study was to explore the importance of KIT exon 11 ITD mutation status and known clinical and pathological indices in predicting prognosis in a cohort of Australian dogs diagnosed with MCT. Methods Clinical parameters, survival data, and KIT mutation status were collected and assessed for 220 dogs with cutaneous or subcutaneous MCT (n = 189 and n = 31, respectively). Results In at least one of the multivariable models, tumour grade (cutaneous Kiupel low or high grade) or tumour subcutaneous location, multiple concurrent MCTs, metastasis at the time of surgery, and senior age were statistically significant in predicting the outcome (MCT‐related death and/or second MCT diagnosis) at 6‐ or 12‐month post‐tumour excision. KIT exon 11 ITD mutation status was not a significant predictor in any of the final multivariable models and was strongly correlated with high histological grade (p < 0.001). Conclusion In this sample of dogs, tumour histological grading remained the single most powerful prognostic indicator for MCT outcome. However, concurrent evaluation of multiple prognostically significant parameters provides information of potential value to inform therapeutic management for each patient.

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Mast Cell Tumors

Cited by 37 publications

References 134 publications

Mast cell tumor within a lipoma in a white toy poodle

Mast cell tumor within a lipoma in a white toy poodle

Reductions in margin length after excision of grade II mast cell tumors and grade I and II soft tissue sarcomas in dogs

Canine mast cell tumours part I: Clinical and survival outcomes

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