Mast cells and their activation in lung disease

Virk, Harvinder; Arthur, Greer; Bradding, Peter

doi:10.1016/j.trsl.2016.01.005

Cited by 70 publications

(55 citation statements)

References 193 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Studies of mast cells initially focused on asthma and allergic diseases. However, in recent decades, more studies have found that mast cells also participate in innate and adaptive immune‐related diseases, including cancer . As a hormone‐dependent tumour, CAFs in prostate tumours have a higher oestrogen receptor/androgen receptor (ER/AR) ratio compared with NFs.…”

Section: Crosstalk Between Cancer‐associated Fibroblasts and Immune Cmentioning

confidence: 99%

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Liu

Chen

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

Multiple studies have shown that cancer‐associated fibroblasts (CAFs) play an important role in tumour progression, including carcinogenesis, invasion, metastasis and the chemoresistance of cancer cells. Immune cells, including macrophages, natural killer cells, dendritic cells and T cells, play a dual role in the tumour microenvironment. Although increasing research has focused on studying interactions between distinct cells in the tumour microenvironment, the complex relationships between CAFs and immune cells remain unclear and need further study. Here, we summarize our current understanding of crosstalk between CAFs and immune cells, which may help clarify their diagnostic and therapeutic value in tumour progression.

show abstract

Section: Crosstalk Between Cancer‐associated Fibroblasts and Immune Cmentioning

confidence: 99%

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Liu

Chen

et al. 2019

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Mast cells and their activation contribute to lung health via innate and adaptive immune responses to respiratory pathogens. However, there is evidence for activation of mast cells contributing to the pathophysiology of lung diseases and cancer . Mast cell‐deficient mice demonstrate significantly attenuated fibrosis and inflammation after environmental injury .…”

Section: Mast Cells and Fungal Infectionsmentioning

confidence: 99%

“…However, there is evidence for activation of mast cells contributing to the pathophysiology of lung diseases and cancer. 88 Mast cell-deficient mice demonstrate significantly attenuated fibrosis and inflammation after environmental injury. 89 Tryptase-positive and chymase-positive mast cells are expanded in the lungs of asthmatic 90 and cystic fibrosis patients.…”

Section: Pathogenic Role Of Mast Cells In Respiratory Fungal Allergymentioning

confidence: 99%

The contribution of mast cells to bacterial and fungal infection immunity

Piliponsky

Romani

2018

Immunological Reviews

View full text Add to dashboard Cite

Mast cells are hematopoietic progenitor-derived, granule-containing immune cells that are widely distributed in tissues that interact with the external environment, such as the skin and mucosal tissues. It is well-known that mast cells are significantly involved in IgE-mediated allergic reactions, but because of their location, it has also been long hypothesized that mast cells can act as sentinel cells that sense pathogens and initiate protective immune responses. Using mast cell or mast cell protease-deficient murine models, recent studies by our groups and others indicate that mast cells have pleiotropic regulatory roles in immunological responses against pathogens. In this review, we discuss studies that demonstrate that mast cells can either promote host resistance to infections caused by bacteria and fungi or contribute to dysregulated immune responses that can increase host morbidity and mortality. Overall, these studies indicate that mast cells can influence innate immune responses against bacterial and fungal infections via multiple mechanisms. Importantly, the contribution of mast cells to infection outcomes depends in part on the infection model, including the genetic approach used to assess the influence of mast cells on host immunity, hence highlighting the complexity of mast cell biology in the context of innate immune responses.

show abstract

“…Mast cells are also considered to play an important role in asthma and contribute to inflammation with bronchoconstriction mediators [33,34]. Furthermore, other cells such as lymphocytes, dendritic cells, macrophages are abundantly present and contribute to inflammation [35].…”

Section: Pathogenesis and Pathophysiologymentioning

confidence: 99%

Ashtma-Chronic obstructive pulmonary disease overlap syndrome (ACOS): current evidence and future research directions

et al. 2017

View full text Add to dashboard Cite

Chronic obstructive pulmonary disease and asthma are the most frequent chronic respiratory diseases that affect the general population. For a long period of time these two conditions were considered to be separate diseases. However, it became evident that some patients share symptoms and clinical findings from both diseases. These patients are considered to represent a distinct phenotype, called asthma-COPD overlap syndrome (ACOS). However, since approximately the one third of the asthmatics smoke the ACOS may primarily define those patients. This is a relatively newly defined clinical syndrome whose underlying mechanisms and most appropriate management remain to be confirmed. In this review, we summarize current knowledge on this syndrome, aiming to update clinicians and help their daily practice.

show abstract

Mast cells and their activation in lung disease

Cited by 70 publications

References 193 publications

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

Crosstalk between cancer‐associated fibroblasts and immune cells in cancer

The contribution of mast cells to bacterial and fungal infection immunity

Ashtma-Chronic obstructive pulmonary disease overlap syndrome (ACOS): current evidence and future research directions

Contact Info

Product

Resources

About