Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas

Rahkola, Dina; Laitala, Joel; Siiskonen, Hanna; Pelkonen, Jukka; Harvima, Ilkka T.

doi:10.1080/07357907.2019.1565765

Cited by 8 publications

(20 citation statements)

References 43 publications

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“…The biological activity of C1q released by MC was confirmed by the reconstitution of C1q‐depleted serum in hemolytic assays 13 . MCs have been demonstrated to produce also C3, particularly in dermatological diseases 16 . C3 can be found in the cytoplasmic compartment of MCs, but not within the cytoplasmic secretory granules 8,16 .…”

Section: Production Of Complement Proteins By Mcsmentioning

confidence: 93%

“…The functions of the C3 convertases are to cleave C3 into two components C3a and C3b 5 . C3a and C3b are formed once the α‐chain of C3 is cleaved by one of the two convertases 16 . C3a acts as a chemoattractant, while C3b promotes complement activation and acts itself as an opsonin and as a ligand for the complement receptor 1 (CR1, CD35) 5 .…”

Section: Complement System At a Glancementioning

confidence: 99%

“…MCs have been demonstrated to produce also C3, particularly in dermatological diseases 16 . C3 can be found in the cytoplasmic compartment of MCs, but not within the cytoplasmic secretory granules 8,16 . Chymase released from MCs may have a role in controlling C3‐associated pathology, as it can degrade the α‐ and β‐chains of C3, as well as isolated C3a 16 .…”

Section: Production Of Complement Proteins By Mcsmentioning

confidence: 99%

“…C3 can be found in the cytoplasmic compartment of MCs, but not within the cytoplasmic secretory granules 8,16 . Chymase released from MCs may have a role in controlling C3‐associated pathology, as it can degrade the α‐ and β‐chains of C3, as well as isolated C3a 16 . Culturing skin MCs revealed their capacity to produce complement proteins in response to cytokines.…”

Section: Production Of Complement Proteins By Mcsmentioning

confidence: 99%

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Mast cells and complement system: Ancient interactions between components of innate immunity

Komi

Shafaghat

Kovanen

et al. 2020

Allergy

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The emergence and evolution of the complement system and mast cells (MCs) can be traced back to sea urchins and the ascidian Styela plicata, respectively. Acting as a cascade of enzymatic reactions, complement is activated through the classical (CP), the alternative (AP), and the lectin pathway (LP) based on the recognized molecules. The system's main biological functions include lysis, opsonization, and recruitment of phagocytes. MCs, beyond their classic role as master cells of allergic reactions, play a role in other settings, as well. Thus, MCs are considered as extrahepatic producers of complement proteins. They express various complement receptors, including those for C3a and C5a. C3a and C5a not only activate the C3aR and C5aR expressing MCs but also act as chemoattractants for MCs derived from different anatomic sites, such as from the bone marrow, human umbilical cord blood, or skin in vitro. Cross talk between MCs and complement is facilitated by the production of complement proteins by MCs and their activation by the MC tryptase. The coordinated activity between MCs and the complement system plays a key role, for example, in a number of allergic, cutaneous, and vascular diseases. At a molecular level, MCs and complement system interactions are based on the production of several complement zymogens by MCs and their activation by MC‐released proteases. Additionally, at a cellular level, MCs act as potent effector cells of complement activation by expressing receptors for C3a and C5a through which their chemoattraction and activation are mediated by anaphylatoxins in a paracrine and autocrine fashion.

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Section: Production Of Complement Proteins By Mcsmentioning

confidence: 93%

Section: Complement System At a Glancementioning

confidence: 99%

Section: Production Of Complement Proteins By Mcsmentioning

confidence: 99%

Section: Production Of Complement Proteins By Mcsmentioning

confidence: 99%

See 2 more Smart Citations

Mast cells and complement system: Ancient interactions between components of innate immunity

Komi

Shafaghat

Kovanen

et al. 2020

Allergy

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“…IHC studies showed a positive correlation between the number of C3c + MCs and CD11b + cells in BCC, which may be a mechanism through which MCs convey immunoregulation by complement components including C3, C3b, and iC3b to BCC resident CD11b + cells. Myeloid‐derived suppressor cells (MDSC) are CD11b + cells that increase in SCC, and their function is in favor of the progression of the tumor mainly by suppressing antitumor responses 17 . The crosstalk between MCs and MDSCs needs to be investigated in SCC.…”

Section: Mast Cell Involvement In the Pathology Of Nmscs: Bccmentioning

confidence: 99%

The emerging role of mast cells in skin cancers: involved cellular and molecular mechanisms

Komi

Jalili²

2021

Int J Dermatology

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Skin cancers are the most common cancers worldwide. They can be divided into nonmelanoma skin cancers (NMSC) including basal cell carcinoma (BCC), squamous cell carcinoma (SCC), and less common lymphomas and merkel cell carcinoma, and melanomas. Melanomas comprise less than 5% of skin cancer rate but are responsible for more than 90% of skin cancer death. Mast cells (MCs) are multifunctional cells that play an important role in inflammatory and allergic reactions. They attract other key players of the immune system by releasing cytokines. Healthy human skin comprises MCs under physiological status, and the number can increase under certain conditions including skin malignancies postulating their possible role in pathogenesis of and immunity against skin cancers. MCs respond to cytokines released by tumor stromal cells, release mediators (including histamine and tryptase), and induce the neovascularization, degradation of extracellular matrix (ECM), and induce mitogenesis. However, MCs may use molecular mechanisms to exert immunosuppressive activity including releasing complement C3, lower expression of CD40L, and overexpression of enzymes with vitamin D3 metabolizing activity including CYP27A1 and CYP27B1. This review summarizes the current knowledge on the role of MCs in pathogenesis and immunity against skin cancers.

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Mast cells and ocular surface: An update review

Barone,

Scirocco,

Surico

et al. 2024

Experimental Eye Research

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Mast Cells Are a Marked Source for Complement C3 Products That Associate with Increased CD11b-Positive Cells in Keratinocyte Skin Carcinomas

Cited by 8 publications

References 43 publications

Mast cells and complement system: Ancient interactions between components of innate immunity

Mast cells and complement system: Ancient interactions between components of innate immunity

The emerging role of mast cells in skin cancers: involved cellular and molecular mechanisms

Mast cells and ocular surface: An update review

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