Mast cells mediate acid-induced augmentation of opossum esophageal blood flow via histamine and nitric oxide

Feldman, Michael J.; Morris, Gerald P.; Dinda, P. K.; Paterson, William G.

doi:10.1053/gast.1996.v110.pm8536848

Cited by 55 publications

(43 citation statements)

References 20 publications

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“…The increased expression of NOS in the microenvironments of the biliary tree in cirrhosis found in this study may be responsible for the changes of PVP, particularly in cirrhosis. The increased blood flow through the MC-derived histamine-and NO-dependent system was welldocumented as contributing to the mucosal defense in the other regions of the gastrointestinal tract (Feldman et al, 1996). This may also be the case in the intrahepatic biliary tree.…”

Section: Discussionmentioning

confidence: 95%

“…The close topologic and numeric association of the peribiliary MC and the small vessels of PVP suggests that the peribiliary MC participate directly or indirectly in the regulation of these vessels by an autocrine and/or paracrine effect. In other organs, such as the esophagus and stomach, the regulatory roles of MC in the microcirculation are well known (Feldman et al, 1996;Wallace et al, 1992). To investigate how peribiliary MC might be involved in the hemodynamic regulation of PVP, we examined the expression of vasoactive substances in the tissues.…”

Section: Discussionmentioning

confidence: 99%

“…Feldman et al (1996) disclosed that, in the esophagus, MC-derived histamine, acting through an NO-dependent mechanism, plays a central role in the vasodilating response to luminal acid of the esophageal microcirculation, and the resultant esophageal hyperemia protects the esophageal mucosa. A part of the peribiliary MC population was immunoreactive for histamine in normal and cirrhotic livers in this study.…”

Section: Koda Et Almentioning

confidence: 99%

“…For example, the role of MC in the regulation of gastric mucosal blood flow was reported by Wallace et al (1992). Feldman et al (1996) disclosed that the hyperemic response of the esophageal mucosa to capsaicin was attenuated by the MC stabilizer doxantrazole. Additionally, MC are also involved in the synthesis of nitric oxide (NO) in endothelial cells.…”

mentioning

confidence: 99%

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Evidence of the Participation of Peribiliary Mast Cells in Regulation of the Peribiliary Vascular Plexus Along the Intrahepatic Biliary Tree

Koda

Harada

Tsuneyama

et al. 2000

Laboratory Investigation

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SUMMARY:Our pilot study disclosed that tryptase-positive mast cells (MC) were densely distributed around the intrahepatic bile ducts (peribiliary MC). In this study, the pathophysiologic roles of these MC were examined with respect to the microcirculation around the bile duct in 71 cases of histologically normal liver, 24 cases of chronic hepatitis, and 45 cases of liver cirrhosis. The tryptase-positive MC were very close to the microvessels of the peribiliary vascular plexus (PVP), which supply the intrahepatic biliary tree. The tryptase-positive MC were frequently found adjacent to vascular smooth muscle cells, including pericytes. The location of the tryptase-positive MC was confirmed by ultrastructural analysis. In cirrhosis, the numbers of both microvessels of PVP and peribiliary MC increased in parallel. Peribiliary MC were immunoreactive for endothelin 1 (ET-1), and were variably immunoreactive for histamine, chymase, inducible nitric oxide synthase (iNOS), and endothelin A and B (ET A and ET B ) receptors, particularly in cirrhotic livers. On vascular endothelial cells of PVP, endothelial nitric oxide synthase (eNOS) and ET-1 were consistently detectable, and ET A receptors, ET B receptors, and iNOS were variably detectable. Pericytes of PVP expressed ET A and ET B receptors in addition to ET-1 and iNOS. Biliary epithelial cells also focally expressed iNOS, ET-1, and ET A and ET B receptors. These vasoactive substances were strongly expressed on the cellular components in cirrhotic liver. By in situ hybridization, iNOS mRNA signals were observed on iNOS-immunoreactive cell components, including peribiliary MC. These morphologic and immunohistochemical findings suggest that the cellular components displaying vasoactive substances in the milieu of the intrahepatic biliary tree are very dynamic in the vasoregulation of PVP in normal livers, even more so in cirrhosis, and that peribiliary MC exert local effects on the microcirculation of PVP, directly and indirectly. A list of abbreviations: AMeX, acetone, methyl benzoate, and xylene; ASMA, ␣-smooth muscle actin; ET, endothelin; ET-1, endothelin 1; ET A receptor, endothelin A receptor; ET B receptor, endothelin B receptor; eNOS, endothelial nitric oxide synthase; MC, mast cell; MC T , tryptase positive, chymase negative mast cells; MC TC , tryptase positive, chymase positive mast cells; NO, nitric oxide; iNOS, inducible nitric oxide synthase; PBS, phosphate buffer saline; PVP, peribiliary vascular plexus; TNF-, tumor necrosis factor ␣ (Lab Invest 2000, 80:1007-1017.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Koda Et Almentioning

confidence: 99%

mentioning

confidence: 99%

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Evidence of the Participation of Peribiliary Mast Cells in Regulation of the Peribiliary Vascular Plexus Along the Intrahepatic Biliary Tree

Koda

Harada

Tsuneyama

et al. 2000

Laboratory Investigation

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“…There is, however, clearly a role for MCs in regulating oesophageal function, with mast cell degranulation and release of histamine into the oesophageal lumen during acute acid-induced injury [63] . Intestinal MCs express CRH receptors [3,64] , and Wu et al [65] identified CRH receptor subtype 2 in the oesophageal mucosa of the rat, along with expression of the cognate CRH receptor ligands urocortin 1 and 2.…”

Section: Mcs In Gastro-oesophageal Reflux Diseasementioning

confidence: 99%

Mast Cells and Mastocytosis

Söderholm¹

2009

Dig Dis

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Mast cells (MCs) typically reside at barrier sites of the body, including the intestinal mucosa, and play a vital role in innate host defence. Activated MCs release a wide variety of bioactive mediators. These include preformed mediators stored in the granules (e.g. histamine and tryptase) and newly synthesised mediators (e.g. prostaglandins, leukotrienes and cytokines). MCs are present in all layers throughout the gastrointestinal (GI) tract and there is a close bi-directional connection between MCs and enteric nerves that is of vital importance in the regulation of GI functions. Some gain-of-function mutations in c-kit, encoding the tyrosine kinase- receptor for stem cell factor, are associated with the rare disease entity, systemic mastocytosis. These patients present symptoms arising from MC mediator release or infiltration. GI manifestations are common in this patient group, mainly abdominal pain and diarrhoea. Endoscopy with biopsies reveals MC infiltration in the mucosa. Other diagnostic tools include bone marrow biopsy and serum tryptase. Treatment is symptomatic with antihistamines or cromoglycate in mild cases, whereas severe cases need cytoreductive therapy that should be managed with expert haematologists. From a day-to-day clinical perspective, the important role of MCs in neuroimmune interaction has been implicated in the intestinal response to stress, in alterations of mucosal and neuromuscular function in irritable bowel syndrome or inflammatory bowel disease, and in the pathogenesis of non-erosive oesophageal reflux disease. Thus, MCs have important regulatory and protective roles in innate defence, in addition to being a potential mediator of mucosal pathophysiology in GI diseases. We need to learn how to balance the response of these volatile cells to be able to benefit from their versatility.

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Esophageal Epithelial Resistance

Orlando¹

2012

The Esophagus

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Mast cells mediate acid-induced augmentation of opossum esophageal blood flow via histamine and nitric oxide

Cited by 55 publications

References 20 publications

Evidence of the Participation of Peribiliary Mast Cells in Regulation of the Peribiliary Vascular Plexus Along the Intrahepatic Biliary Tree

Evidence of the Participation of Peribiliary Mast Cells in Regulation of the Peribiliary Vascular Plexus Along the Intrahepatic Biliary Tree

Mast Cells and Mastocytosis

Esophageal Epithelial Resistance

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