Mast cells play a key role in Th2 cytokine-dependent asthma model through production of adhesion molecules by liberation of TNF-α

Chai, Ok Hee; Han, Eui-Hyeog; Lee, Hern-Ku; Song, Chang Ho

doi:10.3858/emm.2011.43.1.004

Cited by 39 publications

(29 citation statements)

References 28 publications

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“…Notably, ICAM-1 is found induced in a number of allergic diseases (34) and implicated in the tissue recruitment of eosinophils and mast cells (27, 28, 35, 36). The ICAM-1 and VCAM-1 are expressed by both eosinophils and mast cells (37, 38) and our data indicates that both are induced in EoE patients. Therefore, we further tested induction of ICAM-1 and VCAM-1 expression by IL-18.…”

Section: Discussionsupporting

confidence: 55%

Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis

Niranjan

Rajavelu

Ventateshaiah

et al. 2015

Clinical Immunology

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Food allergy is one of the major causes that promote EoE; therefore, we tested the hypothesis that IL-18 is involved in food allergen-induced EoE pathogenesis. Accordingly, we examined normal SPT+ and SPT− EoE patient blood and biopsy samples for IL-18, IL-18Rα, ICAM and VCAM expression Herein, we show increased IL-18 level is highly significant in food allergen SPT+ compared to SPT− EoE patients. We also report that IL-18Rα+ cells and mRNA levels are induced in the esophageal biopsies of EoE patients and blood IL-18 levels correlate with esophageal eosinophilia (p<0.01). Additionally, we report that the levels of esophageal eosinophil and mast cells correlate with ICAM expression in human EoE. Mechanistically, we show that IL-18 in vitro stimulates iNKT cells and endothelial cells and induce eosinophil active cytokines IL-5, IL-13. We provide the evidence that IL-18 is critical cytokine involved in activation of iNKT cells and ICAM in promoting human EoE..

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Section: Discussionsupporting

confidence: 55%

Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis

Niranjan

Rajavelu

Ventateshaiah

et al. 2015

Clinical Immunology

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“…Zhao and colleagues have shown that the expression of both the transcription factor nuclear factor-kappaB (NF-κB) and ICAM-1wassignificantly higher in patients with AR compared with non-rhinitic control subjects and that the expression of ICAM-1 mRNA was significantly correlated with the expression of NF-κB [6]. Another study has demonstrated that tumour necrosis factor alpha(TNF-α)significantly increased the expression of ICAM-1 gene expression in cultured human nasal epithelia cells in vitro and that the TNF-mediated-ICAM-1 mRNA and ICAM-1 surface expression at 48 h was significantly inhibited by incubation with human recombinant soluble TNF receptor I and dexamethasone [7]. To our knowledge, the association between ICAM-1 gene polymorphisms and predisposition of an individual to AR has not been reported to date.…”

Section: Introductionmentioning

confidence: 99%

The Association between Polymorphisms in the MRPL4 and TNF-α Genes and Susceptibility to Allergic Rhinitis

Wei

Zhang

et al. 2013

PLoS ONE

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BackgroundAllergic rhinitis (AR) is a chronic inflammatory disease of the nasal mucosa, involving a complex interaction between genetic and environmental factors. Evidence suggests that polymorphisms in the gene coding for mitochondrial ribosomal protein L4 (MRPL4), located in close proximity to intercellular adhesion molecule-1 (ICAM-1) gene on chromosome location 19p13.2, may influence the risk factor for the development of AR.ObjectiveThe aim of our study was to investigate any association between AR susceptibility and polymorphisms in ICAM-1 gene, as well as associations between AR risk and polymorphisms in MRPL4, nuclear factor-kappaB (NF-κB) and tumor necrosis factor alpha(TNF-α) genes, associated with ICAM-1 expression.MethodsA cohort of 414 patients with AR and 293 healthy controls was enrolled from the Han Chinese population in Beijing, China. Blood was drawn for DNA extraction and total serum immunoglobulin E (IgE). A total of 14 single nucleotide polymorphisms (SNPs) in ICAM-1, NF-κB, TNF-α, and MRPL4 genes were selected using the CHB genotyping data from the International Haplotype Mapping (HapMap) and assessed for differences in frequencies of the alleles and genotypes between the AR patients and control subjects.ResultsTNF-α SNP rs1799964 and MRPL4 SNP rs11668618 were found to occur in significantly greater frequencies in the AR group compared to control group. There were no significant associations between SNPs in NF-κB, ICAM-1 and AR. The SNP-SNP interaction information analysis further indicated that there were no synergistic effects among the selected sets of polymorphisms.ConclusionsOur results suggest a strong association between AR risk and polymorphisms of MRPL4 and TNF-α genes in Han Chinese population.

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“…11 The total number of viable cells in BAL fluid was determined by trypan blue exclusion using a hemocytometer. Differential cell counts were determined Mice in the control group were sensitized and challenged by saline, respectively.…”

Section: Collection and Analysis Of Bronchoalveolar Lavage Fluidmentioning

confidence: 99%

“…11 Animals were sacrificed with an overdose of ether 48 h after the last OVA exposure, and histological specimens were collected. Using routine histological procedures for light microscopic evaluation, tissue specimens were taken from the mid-zone of the left lung of the mice and fixed in 10% formalin and embedded in paraffin.…”

Section: Histopathology and Histochemistrymentioning

confidence: 99%

“…8 Released histamines could contribute to bronchoconstriction, airway hyperresponsiveness, eosinophilic infiltration, and mucus hypersecretion. [9][10][11] At present, antihistamines are commonly used as a therapy for asthma to produce acute bronchodilation. 12 However, these drugs tend to cause side effects and reduce receptor binding affinity and T-cell responses.…”

Section: Introductionmentioning

confidence: 99%

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CheonggukjangEthanol Extracts Inhibit a Murine Allergic Asthma via Suppression of Mast Cell-Dependent Anaphylactic Reactions

Bae

Shin

See

et al. 2014

Journal of Medicinal Food

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Cheonggukjang (CGJ), a traditional Korean fermented soybean food, exerts immunomodulatory effects. Asthma is the most common chronic allergic disease to be associated with immune response to environmental allergens. In the pathogenesis of asthma, histamine is one of the important inflammatory mediators released from granules of mast cells. In this study, we evaluated the therapeutic effect of CGJ on a mouse model of ovalbumin (OVA)-induced asthma via the suppression of histamine release. C57BL/6 mice were sensitized by intraperitoneal injection of OVA or a phosphate-buffered saline (PBS) control and then challenged with OVA inhalation. Mice were treated intraperitoneally with either 70% ethanol-extracted CGJ (CGJE) (100 mg/kg/day) or equivalent PBS. Asthma-related inflammation was assessed by bronchoalveolar lavage fluid cell counts and histopathological and immunohistochemical analysis of lung tissues. To elucidate the mechanisms of asthma inhibition by CGJE treatment, we also examined degranulation and histamine release of compound 48/80-induced rat peritoneal mast cells (RPMCs). Treatment with CGJE downregulated the number of eosinophils and monocytes in the lungs of mice challenged with OVA and suppressed histopathological changes, such as eosinophil infiltration, mucus accumulation, goblet cell hyperplasia, and collagen fiber deposits. Moreover, CGJE alleviated compound 48/80-induced mast cell degranulation and histamine release from RPMCs through inhibition of calcium (Ca 2 + ) uptake as well as ear swelling by infiltration of inflammatory cells. These findings demonstrated that CGJE can be used as an antiasthmatic dietary supplements candidate for histamine-mediated asthma.

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Mast cells play a key role in Th2 cytokine-dependent asthma model through production of adhesion molecules by liberation of TNF-α

Cited by 39 publications

References 28 publications

Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis

Involvement of interleukin-18 in the pathogenesis of human eosinophilic esophagitis

The Association between Polymorphisms in the MRPL4 and TNF-α Genes and Susceptibility to Allergic Rhinitis

CheonggukjangEthanol Extracts Inhibit a Murine Allergic Asthma via Suppression of Mast Cell-Dependent Anaphylactic Reactions

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