Mastocytosis

Naeim, Faramarz

doi:10.1016/b978-0-12-370607-2.00020-x

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…Interestingly, other researchers did not see a statistically significant difference in the expression of CD13, CD11, CD62L, or ICAM-1 in post-flight blood-derived monocytes 55 . CD13, also known as alanine aminopeptidase, is associated with homotypic cell adhesion in monocytes, though appears to potentially show activity in leukocyte migration as well 56 ; CD11 is the alpha component of numerous integrins, including the previously mentioned CD18, that mediate monocyte/macrophage and other leukocyte adhesion 57 . Collectively, these studies show evidence that the expression of cell adhesion integrins is altered to varying degrees in both simulated and actual microgravity, and also varies with species and tissue-type.…”

Section: Adhesion and Migrationmentioning

confidence: 99%

Macrophages in microgravity: the impact of space on immune cells

et al. 2021

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The effects of a microgravity environment on the myriad types of immune cells present within the human body have been assessed both by bench-scale simulation and suborbital methods, as well as in true spaceflight. Macrophages have garnered increased research interest in this context in recent years. Their functionality in both immune response and tissue remodeling makes them a unique cell to investigate in regards to gravisensitive effects as well as parameters of interest that could impact astronaut health. Here, we review and summarize the literature investigating the effects of microgravity on macrophages and monocytes regarding the microgravity environment simulation/generation methods, cell sources, experiment durations, and parameters of interest utilized within the field. We discuss reported findings on the impacts of microgravity on macrophage/monocyte structure, adhesion and migration, proliferation, genetic expression, cytokine secretion, and reactive oxygen species production, as well as polarization. Based on this body of data, we make recommendations to the field for careful consideration of experimental design to complement existing reports, as the multitude of disparate study methods previously published can make drawing direct comparisons difficult. However, the breadth of different testing methodologies can also lend itself to attempting to identify the most robust and consistent responses to microgravity across various testing conditions.

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Section: Adhesion and Migrationmentioning

confidence: 99%