Mastocytosis Occurring in the Testes From Patients With Idiopathic Male Infertility

Maseki, Yoshiro; Miyake, Koji; Mitsuya, Hideo; Kitamura, Hirokazu; Yamada, Kazuyorí

doi:10.1016/s0015-0282(16)45931-5

Cited by 50 publications

(37 citation statements)

References 6 publications

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“…The present results are similar to those published by others (27)(28)(29) who highlighted the increased number of mast cells in testicular lesions associated with infertility. Meineke et al (29) observed, as we did, a shift of mast cells from interstitium to tubular wall.…”

Section: Discussionsupporting

confidence: 93%

Mast cells in testicular lesions

Kollur¹,

Pattankar²,

Hag³

2004

Upsala Journal of Medical Sciences

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Section: Discussionsupporting

confidence: 93%

Mast cells in testicular lesions

Kollur¹,

Pattankar²,

Hag³

2004

Upsala Journal of Medical Sciences

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“…It therefore remains to be shown whether the tryptase-signaling pathway is of importance in all or only some cases of fibrosis. We have started to address this question by evaluating human tissues in which both fibrotic tissue remodeling and increased numbers of activated mast cells have been well documented, namely testes from infertile men (18,(29)(30)(31)(32)(33).…”

Section: Discussionmentioning

confidence: 99%

“…To examine whether this newly identified pathway may be of relevance to a human fibrotic disorder, we studied human testicular biopsies from men presenting normal, mildly, or severely impaired spermatogenesis (18). We studied this tissue, because it is well documented (18,(29)(30)(31)(32)(33)) that interstitial and peritubular tryptase-positive mast cells are 2-3 times increased and show signs of activation͞ degranulation in these cases (Fig. 3a).…”

Section: Identification Of the Components Required For The Tryptase͞cmentioning

confidence: 99%

Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARγ: Possible relevance to human fibrotic disorders

Frungieri

Weidinger

Meineke

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

238

229

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Mast-cell products can stimulate fibroblast proliferation, implying that these cells are key players in fibrosis. One mast-cell product, the serine protease tryptase, is known to activate protease-activated receptor 2 (PAR2) and cause proliferation of fibroblasts. We found that recombinant tryptase, human mastcell (HMC-1) supernatant, which contains tryptase, and the PAR2-activating peptide SLIGKV exert fibroproliferative actions in human fibroblasts. Here we report insights into this action, which after activation of PAR2 leads to increased expression of cyclooxygenase 2 (COX2), a key enzyme in the biosynthesis of prostaglandins, and consequently to enhanced prostaglandin synthesis. Subsequent cell proliferation is mediated by the prostaglandin 15-deoxy-⌬ 12,14 -prostaglandin J2, which acts via the nuclear peroxisome proliferator-activated receptor ␥ (PPAR␥). Fibroblast proliferation induced by tryptase and PAR2 agonist peptide can be blocked by antagonists of COX2 and PPAR␥, implying that the proliferative effect of tryptase is PAR2-initiated but depends on COX2, 15-deoxy-⌬ 12,14 -prostaglandin J2, and PPAR␥. This previously uncharacterized pathway could be of relevance for human fibrotic diseases. For instance, increased numbers of activated mast cells are correlated with fibrosis in testes of infertile men. In these cases all components of the signaling pathway of tryptase were detected as well as expression of COX2. Therefore, our study describes as-yet-unknown interactions between mast cells and fibroblasts, which could be relevant for human fibrotic diseases.

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“…This may be attributed to both connective tissue proliferation and edema formation. The participation of mast cells in the development of connective tissue has been reported by many investigators [ l , 14,15,171. Mast cells stimulate mitosis in fibroblasts [22], collagen fiber synthesis [ l , 151, and the packing and organization of collagen fibers [3,18,251.…”

mentioning

confidence: 95%

“…Mast cell proliferation occurs in a great variety of both benign and malignant disorders [4, 10, 261. Recently, Maseki et al [14] reported increased numbers of mast cells in the testis from men with idiopathic male infertility.…”

Section: Introductionmentioning

confidence: 99%