2024
DOI: 10.1101/2024.01.18.576318
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Matched three-dimensional organoids and two-dimensional cell lines of melanoma brain metastases mirror response to targeted molecular therapy

William H. Hicks,
Lauren C. Gattie,
Jeffrey I Traylor
et al.

Abstract: Purpose:Despite significant advances in the treatment paradigm for patients with metastatic melanoma, melanoma brain metastasis (MBM) continues to represent a significant treatment challenge. The study of MBM is limited, in part, by shortcomings in existing preclinical models. Surgically eXplanted Organoids (SXOs) are ex vivo, three-dimensional cultures prepared from primary tissue samples with minimal processing that recapitulate genotypic and phenotypic features of parent tumors and are grown without artific… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 37 publications
(56 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?