Material properties and compaction characteristics of natural and pregelatinized forms of four starches

Adedokun, Musiliu O.; Itiola, O. A.

doi:10.1016/j.carbpol.2009.10.009

Cited by 77 publications

(48 citation statements)

References 16 publications

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“…The NCF cookies that contained the cross-linked starch contained the highest moisture. According to Adedokun and Itiola [20] pregelatinized starches have a greater ability to swell and retain water compared to regular starch after heating. Dietary fiber values were significantly higher for all nixtamalized corn flour cookies treatments (5.9 to 6.5%) compared to cookies produced from refined wheat flour (3.9%).…”

Section: Cookies Physicochemical Characteristicsmentioning

confidence: 99%

Effect of Maize Starch Substitution on Physicochemical and Sensory Attributes of Gluten-Free Cookies Produced from Nixtamalized Flour

Pérez‐Carrillo

Frías-Escobar

Gutiérrez-Mendívil

et al. 2017

Journal of Food Processing

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Nixtamalized corn flour (NCF) has a good dietary fiber profile that makes it an alternative to produce gluten-free cookies because upon hydration and mixing it yields a cohesive and machinable dough. In order to improve the texture and acceptance of cookies, five different experimental treatments were devised and compared with a cookie made with refined wheat flour. A waxy native maize or pregelatinized cross-linked starches in concentrations of 5% and 10% were evaluated. Results showed that the spread factor, diameter, and thickness of the different types of cookies were not statistically different ( > 0.05). With the exception of the control and cookies made with 10% waxy starch which were rated with lower scores, the rest of the treatments were not significantly different in terms of sensory attributes. The texture of cookies evaluated by panelists related to the objective texture was determined with the texture analyzer. Cookies made from the composite flour containing 10% pregelatinized cross-linked were softer or had lower maximum positive force after 5 days of storage. This particular gluten-free cookie contained 65% more dietary fiber compared to the wheat flour counterpart and had the best sensory attributes among all treatments including the cookie made with refined wheat flour.

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Section: Cookies Physicochemical Characteristicsmentioning

confidence: 99%

Effect of Maize Starch Substitution on Physicochemical and Sensory Attributes of Gluten-Free Cookies Produced from Nixtamalized Flour

Pérez‐Carrillo

Frías-Escobar

Gutiérrez-Mendívil

et al. 2017

Journal of Food Processing

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“…Each tablet was placed diametrically between the jaws of the tester and the force needed to just crush the tablet was noted. The mean of the hardness was also determined [23,25].…”

Section: Hardness Testmentioning

confidence: 99%

“…The tablets were then removed, de-dusted and weighed again. The friability of the tablets was expressed as a percentage using the formula below [23,25]. In vitro dissolution test for the tablets was carried out using the United States Pharmacopoeia basket method in the tablet dissolution test apparatus [26].…”

Section: Friability Testmentioning

confidence: 99%

Optimized Delivery of Diclofenac Sodium Formulated in a Sustained Release Raphia Africana Hydrocolloid Matrix

Adedokun

Nkanta

2018

Int J App Pharm

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Objective: The aim of this research work was to comparatively study various proportions of a natural hydrocolloid-Raphia africana, and polyvinylpyrrolidone (PVP) as release sustaining agents in diclofenac sodium tablet formulation. Methods:The purified hydrocolloid (R. africana) was characterized by evaluating its organoleptic, physicochemical and flow properties. Diclofenacpolymer ratios of 1:0, 1:0.2, 1:0.4, 1:0.6, and 1:0.8 were employed to produce different granule batches using wet granulation method (that is, the drug was formulated with 0, 5, 10, 15 and 20 % w/w of either R. africana hydrocolloid or PVP, and coded DWB-00, DRA-05, DRA-10, DRA-15, DRA-20, DPP-05, DPP-10, DPP-15 and DPP-20, respectively). Flow properties of granules were studied by determining bulk density, tapped density, Carr's index, and Hausner's ratio for all the formulations. Compressed tablets were evaluated using various parameters as weight variation, friability, hardness, tablet thickness and diameter, content uniformity and in vitro dissolution evaluated in phosphate buffer (pH 7.3).Results: Flowability, mechanical and release parameters determined were within pharmacopoeial limits. Generally, the values of bulk and tapped densities increase as binder concentrations increase for both PVP and R. africana hydrocolloid. The values were significantly different across the batches (p<0.05). Hardness values obtained varied significantly (p<0.05) and were between 5 and 12 KgF which imply that most of the tablet batches are harder than normal depending on the proportion of the polymer used. All the batches exhibited friability within the standard limit without significant difference in values (p>0.05), indicating that tablet formulated with the experimental binders would not undergo surface abrasion. All the formulations exhibited zero order kinetics except batches DPP-10 and DPP-15 which showed Higuchi mechanism. Formulation batches DRA-05 and DRA-10 showed maximum drug release of 98% and 95% respectively after 6 h. A prolonged drug release was observed on increasing polymer ratio. Significantly higher release rates (p<0.05) were observed in the tablets formulated with PVP than those containing R. africana gum. All the batches followed non-fickian diffusion release mechanism. Conclusion:From the study, purified R. africana hydrocolloid generally appeared to perform better than PVP as sustained release agent.

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“…Ten tablets from each batch were used and method reported by various workers was employed [12,[14][15][16]. The tablets were dusted, weighed (wi) and put in Erweka model friabilator (Roche, England).…”

Section: Friability Testmentioning

confidence: 99%

Physico-Mechanical and Release Properties of Sustained Release Artesunate Tablets in Hydroxypropyl Methylcellulose Matrix

2018

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Objective: This work was aimed at formulating artesunate tablets with hydroxypropyl methylcellulose (HPMC)-a hydrophilic polymer for the purpose of achieving a sustained release profile of the drug and evaluating their properties. Methods:The solubility profile of artesunate was determined in water, methanol, ethanol, ethanol/water mixtures (50/50, 40/60 v/v), simulated intestinal fluid (SIF) without enzymes (pH 7, 7.2 and 8), simulated gastric fluid (SGF) without enzymes (pH 1.2), 0.1N hydrochloric acid (HCI), 0.1N sodium hydroxide (NaOH), 0.1N acetic acid and phosphate buffer solution, PBS (pH 7, 7.2 and 8). Four batches of oral sustained release artesunate tablets intended for once-daily dosing were formulated with 10%, 20%, 25% and 30% w/w concentrations of HPMC using wet granulation method. Evaluation of granule properties was done by determining the angle of repose, flow rate, bulk density, tapped density, Carr's index and Hausner's quotient. The compressed tablets were also evaluated using official and non-official parameters. Absolute drug contents were determined in 0.1N NaOH, ethanol and methanol. In vitro release was studied in different media and release kinetics mechanism elucidated. In vivo studies were carried out using healthy Wistar rats. Results:Artesunate was observed to exhibit solubility at varying degrees depending on solvents or media employed as well as the pH of the media. All the granule batches have Hausner's quotient value of approximately 1.2. The values for Carr's index for all the batches ranged between 30 and 40. The angle of repose, Carr's index and Hausner's quotient values indicate good flow properties of the granules for all the batches. All the tablet batches conformed to official standard in terms of weight uniformity as no single tablet deviated beyond 5% from the average weight in each batch with no significant difference in the values (p>0.05). Values of hardness increased insignificantly from batches A to D (p>0.05). Friability values were very low and follows no specific pattern among the batches but the difference in the values was significant (p<0.05). Absolute drug content reduced while in vitro release times increased as hardness increased, indicating the probable progressive reduction in the tendency of the matrix to release the drug as the concentration of HPMC increased from batches A to D. n values obtained from analysis of release mechanism were above 0.89 for each batch. Conclusion:The release mechanism was shown to be complex and the release involved zero order, first order, and Higuchi model kinetics. The biological half-life of artesunate was shown to be 1.05 hr, and metabolites which bear resemblance to artesunate in absorbance seem to be encountered. In this work, HPMC matrix yielded high-quality tablets indicating its usefulness in sustained released product development.

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Material properties and compaction characteristics of natural and pregelatinized forms of four starches

Cited by 77 publications

References 16 publications

Effect of Maize Starch Substitution on Physicochemical and Sensory Attributes of Gluten-Free Cookies Produced from Nixtamalized Flour

Effect of Maize Starch Substitution on Physicochemical and Sensory Attributes of Gluten-Free Cookies Produced from Nixtamalized Flour

Optimized Delivery of Diclofenac Sodium Formulated in a Sustained Release Raphia Africana Hydrocolloid Matrix

Physico-Mechanical and Release Properties of Sustained Release Artesunate Tablets in Hydroxypropyl Methylcellulose Matrix

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