Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

Zhao, Dayong; Yu, Ke-Da; Sun, Tingfang; Jing, Xirui; Wan, Yizhou; Chen, Kaifang; Gao, Huijie; Wang, Yifan; Chen, Lili; Guo, Xiaodong; Wei, Qingsong

doi:10.1002/adfm.202213128

Cited by 29 publications

(16 citation statements)

References 69 publications

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“…However, the newly formed bone tissue did not significantly grow into the pores of the two scaffolds, indicating a need for the further improvement of osteogenic ability. [30] Ideal orthopedic implants should have the customizable biodegradable performance and good osteogenic ability for the specific patient. The parameters of structure design, such as porosity and unit size, can significantly influence the properties of scaffolds.…”

Section: Introductionmentioning

confidence: 99%

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Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability

Wang,

Liu,

Zhang

et al. 2023

Advanced Science

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The combination of bioactive Zn‐2Mg alloy and additively manufactured porous scaffold is expected to achieve customizable biodegradable performance and enhanced bone regeneration. Herein, Zn‐2Mg alloy scaffolds with different porosities, including 40% (G‐40‐2), 60% (G‐60‐2), and 80% (G‐80‐2), and different unit sizes, including 1.5 mm (G‐60‐1.5), 2 mm (G‐60‐2), and 2.5 mm (G‐60‐2.5), are manufactured by a triply periodic minimal surface design and a reliable laser powder bed fusion process. With the same unit size, compressive strength (CS) and elastic modulus (EM) of scaffolds substantially decrease with increasing porosities. With the same porosity, CS and EM just slightly decrease with increasing unit sizes. The weight loss after degradation increases with increasing porosities and decreasing unit sizes. In vivo tests indicate that Zn‐2Mg alloy scaffolds exhibit satisfactory biocompatibility and osteogenic ability. The osteogenic ability of scaffolds is mainly determined by their physical and chemical characteristics. Scaffolds with lower porosities and smaller unit sizes show better osteogenesis due to their suitable pore size and larger surface area. The results indicate that the biodegradable performance of scaffolds can be accurately regulated on a large scale by structure design and the additively manufactured Zn‐2Mg alloy scaffolds have improved osteogenic ability for treating bone defects.

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Section: Introductionmentioning

confidence: 99%

“…However, the newly formed bone tissue did not significantly grow into the pores of the two scaffolds, indicating a need for the further improvement of osteogenic ability. [ 30 ]…”

Section: Introductionmentioning

confidence: 99%

Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability

Wang,

Liu,

Zhang

et al. 2023

Advanced Science

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“…A previous study revealed that Zn-1Mg alloy lead to no side effect on cell multiplication and no cytotoxicity to MG63 osteoblasts, exhibiting improved cytocompatibility [20]. Zhao et al revealed that Zn-3Mg implants trigger appropriate immune responses and appealing osteogenic reactions for guiding bone tissue regeneration [21]. In another previous work, in vivo investigation proved that there is no gas evolution during degradation of a Zn-0.8Mg-0.2 Sr orthopedic implant and no inflammatory reaction or bone resorption under service for 120 d [22].…”

Section: Introductionmentioning

confidence: 99%

Impact of copper on corrosion behavior, biocompatibility and antibaterial activity of biodegradable Zn-3Mg-xCu alloys for orthopedic applications

Wei,

Zhang,

et al. 2023

Mater. Res. Express

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Biodegradable zinc (Zn) based materials have been regarded as promising candidates for orthopedic applications owing to their suitable biodegradability. However, pure Zn exhibited poor mechanical performance and inadequate biofunctionality, which restricted its biomedical applications. Herein, biodegradable Zn-Mg-Cu alloys were developed to enhance the mechanical strength of the Zn matrix and endow the alloys with antibacterial activity. The effect of Cu addition on corrosion behavior, biocompatibility and antibacterial activity of biodegradable Zn-3Mg-xCu alloys was systematically investigated. In vitro immersion test revealed that Zn-3Mg-1Cu exhibited an increasing corrosion rate of 0.0504 mm y−1. The relative cell availability of MC3T3-E1 cells was over 70% after co-culture with 2-fold diluted extracts of the Zn-3Mg-xCu alloy for 3 d, indicating acceptable cytotoxicity. The Cu addition could enhance the antibacterial activity of the Zn-3Mg matrix, and Zn-3Mg-1Cu alloy exhibited the highest inhibition zone diameter (IZD) values of 10.4 mm and 6.0 mm against S. aureus and E. coli, respectively. Overall, the Zn-3Mg-1Cu could be recognized as a promising biodegradable orthopedic material owing to favorable degradation behavior, satisfying biocompatibility, and substantial antibacterial ability.

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“…[1][2][3] However, the biological inertness of PEEK could give rise to poor osseointegration and even disastrous implant-associated infections, which limits its clinical application to some extent. [4,5] Therefore, surface modification of PEEK to introduce positive bioactivities, such as antimicrobial, anti-inflammatory, and pro-osteogenic activities is an efficient solution to prolong the lifespan and expand the clinical application of PEEK implants.…”

Section: Introductionmentioning

confidence: 99%

Dynamical Integration of Antimicrobial, Anti‐Inflammatory, and Pro‐Osteogenic Activities on Polyetheretherketone via a Porous N‐Halamine Polymeric Coating

Wang,

Tang,

Wang

et al. 2023

Adv Funct Materials

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Polyetheretherketone (PEEK) has been widely used as orthopedic implants, but the poor antimicrobial and osseointegration properties hinder its advanced clinical applications. Most of the modification strategies are difficult to temporally fulfill initial broad‐spectrum antimicrobial and later pro‐osteogenic requirements for a long‐term success of implantation. N‐halamine is a kind of biofriendly antimicrobial agent, and its functional N─Cl groups could be converted into N─H groups, potentially resulting in new bioactivities. Therefore, it is supposed that N‐halamine might provide a feasible design for the dynamical integration of antimicrobial and pro‐osteogenic abilities. Herein, a new class of surface‐porous PEEK implant with an N‐halamine polymeric coating (sp‐PEEK‐NCl) is constructed by successive pore‐making, polymer grafting, and chlorination. The as‐prepared sp‐PEEK‐NCl exhibits broad‐spectrum antibacterial, antifungal, anti‐inflammatory, and pro‐osteogenic effects. More importantly, with the consumption of oxidative chlorine, the N─Cl groups in sp‐PEEK‐NCl are transformed into N─H groups with enhanced pro‐osteogenic ability, endowing sp‐PEEK‐NCl with dynamically compatible bioactivities for osseointegration in different periods after implantation. Rat implant‐associated osteomyelitis model confirms that sp‐PEEK‐NCl obviously reduces infectious bone destruction and promotes osseointegration in vivo. This work may provide a promising strategy for intelligent integration of bioactivities and valuable insight into the design of orthopedic implants in bone tissue engineering.

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Material–Structure–Function Integrated Additive Manufacturing of Degradable Metallic Bone Implants for Load‐Bearing Applications

Cited by 29 publications

References 69 publications

Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability

Additively Manufactured Zn‐2Mg Alloy Porous Scaffolds with Customizable Biodegradable Performance and Enhanced Osteogenic Ability

Impact of copper on corrosion behavior, biocompatibility and antibaterial activity of biodegradable Zn-3Mg-xCu alloys for orthopedic applications

Dynamical Integration of Antimicrobial, Anti‐Inflammatory, and Pro‐Osteogenic Activities on Polyetheretherketone via a Porous N‐Halamine Polymeric Coating

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