Materials and techniques used in cranioplasty fixation: A review

Khader, Basel A.; Towler, Mark R.

doi:10.1016/j.msec.2016.04.101

Cited by 87 publications

(86 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The failure of the graft ossification of Patients 2 and 4 may be due to too rapid resorption of betaTCP granules which in turn may be related to the use of resorbable and less rigid supporting meshes in their cases. In future studies, it is pivotal to find an optimal scaffold material to support ossification in cranial area 55, 56.…”

Section: Discussionmentioning

confidence: 99%

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Thesleff

Lehtimäki

Niskakangas

et al. 2017

Stem Cells Translational Medicine

View full text Add to dashboard Cite

Several alternative techniques exist to reconstruct skull defects. The complication rate of the cranioplasty procedure is high and the search for optimal materials and techniques continues. To report long‐term results of patients who have received a cranioplasty using autologous adipose‐derived stem cells (ASCs) seeded on beta‐tricalcium phosphate (betaTCP) granules. Between 10/2008 and 3/2010, five cranioplasties were performed (four females, one male; average age 62.0 years) using ASCs, betaTCP granules and titanium or resorbable meshes. The average defect size was 8.1 × 6.7 cm2. Patients were followed both clinically and radiologically. The initial results were promising, with no serious complications. Nevertheless, in the long‐term follow‐up, three of the five patients were re‐operated due to graft related problems. Two patients showed marked resorption of the graft, which led to revision surgery. One patient developed a late infection (7.3 years post‐operative) that required revision surgery and removal of the graft. One patient had a successfully ossified graft, but was re‐operated due to recurrence of the meningioma 2.2 years post‐operatively. One patient had an uneventful clinical follow‐up, and the cosmetic result is satisfactory, even though skull x‐rays show hypodensity in the borders of the graft. Albeit no serious adverse events occurred, the 6‐year follow‐up results of the five cases are unsatisfactory. The clinical results are not superior to results achieved by conventional cranial repair methods. The use of stem cells in combination with betaTCP granules and supporting meshes in cranial defect reconstruction need to be studied further before continuing with clinical trials. Stem Cells Translational Medicine 2017;6:1576–1582

show abstract

Section: Discussionmentioning

confidence: 99%

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Thesleff

Lehtimäki

Niskakangas

et al. 2017

Stem Cells Translational Medicine

View full text Add to dashboard Cite

show abstract

“…(2,5,6) Hoy en día, el empleo de titanio por parte de los neurocirujanos es más cotidiano, ya que existe vasta bibliografía que demuestra su uso y en gran parte las casas comerciales han hecho una mercadotecnia enfocada a una solución "eficiente", dejando a un lado el aspecto económico de los pacientes, ya que su elevado costo hace que en muchos de los casos los pacientes no puedan pagarlo; adicionando que aún falta por transcurrir tiempo para poder afirmar que el empleo de titanio en pacientes craniectomizados está garantizado. (6)(7)(8) El PMMA es un material que muestra mejores propiedades físicas, mecánicas y biológicas, este es un plástico duro, resistente, transparente, de excelentes propiedades ópticas con alto índice de refracción, buena resistencia al envejecimiento y a la intemperie. Su resistencia a la rotura es siete veces superior a la del cristal a igualdad de espesores, por lo que resulta más resistente a los golpes (9).…”

Section: Craneotomía Y Craneoplastíaunclassified

Polimetilmetacrilato, una alternativa viable para la fabricación de prótesis craneal

Parra-Castañeda

Rivera-Gonzaga

Ancona-Meza

et al. 2018

ICSA

View full text Add to dashboard Cite

Termocurable Polymethyl methacrylate (PMMA) used in cranial reconstructions is observed with favourable experiences, data on the release of residual monomer and its interaction on tissue level have been reported in Scientifics Reports, demonstrating null processes of inflammation either by, interaction of lysosomes of bone cells or some other cell line. However, an incorrect polymerization process and its elaboration, will make the release of residual monomer higher, and thus be affected patient's health. Resumen:El uso de Polimetil metacrilato (PMMA) termocurable en reconstrucciones craneales se observa con experiencias favorables, se ha reportado en la literatura datos sobre la liberación de monómero residual y su interacción a nivel tisular, demostrando nulos procesos de inflamación ya sea por interacción de lisosomas de células óseas o alguna otra línea celular. Sin embargo, un incorrecto proceso de polimerización y elaboración de la misma, hará que la liberación de monómero residual sea mayor, perjudicando así la salud del paciente.

show abstract

“…It should be firm and stable, resistant to infection, heat and cold. Finally, it should be economical 329)…”

Section: Bone Substitute For Cranioplastymentioning

confidence: 99%

Review of Cranioplasty after Decompressive Craniectomy

Cho

Kang

2017

Korean J Neurotrauma

View full text Add to dashboard Cite

Cranioplasty is an in evitable operation conducted after decompressive craniectomy (DC). The primary goals of cranioplasty after DC are to protect the brain, achieve a natural appearance and prevent sinking skin flap syndrome (or syndrome of the trephined). Furthermore, restoring patients' functional outcome and supplementing external defects helps patients improve their self-esteem. Although early cranioplasty is preferred in recent year, optimal timing for cranioplasty remains a controversial topic. Autologous bone flaps are the most ideal substitute for cranioplasty. Complications associated with cranioplasty are also variable, however, post-surgical infection is most common. Many new materials and techniques for cranioplasty are introduced. Cost-benefit analysis of these new materials and techniques can result in different outcomes from different healthcare systems.

show abstract

Materials and techniques used in cranioplasty fixation: A review

Cited by 87 publications

References 64 publications

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Cranioplasty with Adipose-Derived Stem Cells, Beta-Tricalcium Phosphate Granules and Supporting Mesh: Six-Year Clinical Follow-Up Results

Polimetilmetacrilato, una alternativa viable para la fabricación de prótesis craneal

Review of Cranioplasty after Decompressive Craniectomy

Contact Info

Product

Resources

About