Materials chemistry-enabled platforms in detecting sexually transmitted infections: progress towards point-of-care tests

Farokhzad, Nika; Tao, Wei

doi:10.1016/j.trechm.2021.03.009

Cited by 24 publications

(16 citation statements)

References 62 publications

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“…Recent years, materials science has shown its more and more advantages in the understanding, diagnosis, or treatment of the viral diseases. 33 Some carefully designed nanomaterials have the potential direct function of fighting viruses. 34 Based on our previous study experience about biomaterials, 35 we synthesized polyglutamic acid‐polyethylene glycol (PGlu‐PEG) materials in which polyglutamate (Glu) provides carboxyl groups to interact with Ca 2+ , preventing the mineralization of large CaCO 3 blocks, and PEG shell acts to prevent agglomeration and aggregation of particles.…”

Section: Introductionmentioning

confidence: 99%

Nanoantidote for repression of acidosis pH promoting COVID‐19 infection

Liu

Ruan

Sheng

et al. 2022

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Acidosis, such as respiratory acidosis and metabolic acidosis, can be induced by coronavirus disease 2019 (COVID‐19) infection and is associated with increased mortality in critically ill COVID‐19 patients. It remains unclear whether acidosis further promotes SARS‐CoV‐2 infection in patients, making virus removal difficult. For antacid therapy, sodium bicarbonate poses great risks caused by sodium overload, bicarbonate side effects, and hypocalcemia. Therefore, new antacid antidote is urgently needed. Our study showed that an acidosis‐related pH of 6.8 increases SARS‐CoV‐2 receptor angiotensin‐converting enzyme 2 (ACE2) expression on the cell membrane by regulating intracellular microfilament polymerization, promoting SARS‐CoV‐2 pseudovirus infection. Based on this, we synthesized polyglutamic acid‐PEG materials, used complexation of calcium ions and carboxyl groups to form the core, and adopted biomineralization methods to form a calcium carbonate nanoparticles (CaCO3‐NPs) nanoantidote to neutralize excess hydrogen ions (H+), and restored the pH from 6.8 to approximately 7.4 (normal blood pH). CaCO3‐NPs effectively prevented the heightened SARS‐CoV‐2 infection efficiency due to pH 6.8. Our study reveals that acidosis‐related pH promotes SARS‐CoV‐2 infection, which suggests the existence of a positive feedback loop in which SARS‐CoV‐2 infection‐induced acidosis enhances SARS‐CoV‐2 infection. Therefore, antacid therapy for acidosis COVID‐19 patients is necessary. CaCO3‐NPs may become an effective antacid nanoantidote superior to sodium bicarbonate.

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Section: Introductionmentioning

confidence: 99%

Nanoantidote for repression of acidosis pH promoting COVID‐19 infection

Liu

Ruan

Sheng

et al. 2022

VIEW

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“…1 In this review, we provide a comprehensive review of the research status of MINs in therapy and imaging, while the mechanisms of the corresponding MIT are also discussed. Additionally, the applications of MINs in various biomedical fields including cancers, [27][28][29] cardiovascular diseases, 30,31 tissue engineering, [32][33][34][35] neurofunctional diseases, 36,37 and infectious diseases, 38,39 and their combination with other treatment modes are summarized (Scheme 1). Finally, we share our thoughts regarding the challenges, future development, and clinical translation of MINs.…”

Section: Introductionmentioning

confidence: 99%

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

et al. 2022

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“…Electrochemical biosensors have attracted considerable attention as powerful analytical tools in medical diagnostics, because they offer various advantages over other diagnostic procedures in diagnostics, such as high sensitivity, simplicity, rapid response, and cost-effectiveness [38,39]. Among the currently available nucleic acidbased biosensors, electrochemical biosensors have shown their powers for POCT applications as well [40][41][42]. In addition, gold nanoparticle (AuNP) has high biocompatibility, low toxicity, and well-established biochemistryapplication.…”

Section: Introductionmentioning

confidence: 99%

CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant

Chen

et al. 2022

Nano-Micro Lett.

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Coronavirus disease 2019 (COVID-19) is a highly contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gold standard method for the diagnosis of SARS-CoV-2 depends on quantitative reverse transcription-polymerase chain reaction till now, which is time-consuming and requires expensive instrumentation, and the confirmation of variants relies on further sequencing techniques. Herein, we first proposed a robust technique-methodology of electrochemical CRISPR sensing with the advantages of rapid, highly sensitivity and specificity for the detection of SARS-CoV-2 variant. To enhance the sensing capability, gold electrodes are uniformly decorated with electro-deposited gold nanoparticles. Using DNA template identical to SARS-CoV-2 Delta spike gene sequence as model, our biosensor exhibits excellent analytical detection limit (50 fM) and high linearity (R2 = 0.987) over six orders of magnitude dynamic range from 100 fM to 10 nM without any nucleic-acid-amplification assays. The detection can be completed within 1 h with high stability and specificity which benefits from the CRISPR-Cas system. Furthermore, based on the wireless micro-electrochemical platform, the proposed biosensor reveals promising application ability in point-of-care testing.

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Materials chemistry-enabled platforms in detecting sexually transmitted infections: progress towards point-of-care tests

Cited by 24 publications

References 62 publications

Nanoantidote for repression of acidosis pH promoting COVID‐19 infection

Nanoantidote for repression of acidosis pH promoting COVID‐19 infection

Minimally invasive nanomedicine: nanotechnology in photo-/ultrasound-/radiation-/magnetism-mediated therapy and imaging

CRISPR-Cas12a-Empowered Electrochemical Biosensor for Rapid and Ultrasensitive Detection of SARS-CoV-2 Delta Variant

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