Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs

Zhang, Lianhua; Hu, Jie; Li, Miao; Shang, Qinghui; Liu, Sujie; Piao, Xiangshu

doi:10.1007/s00774-019-01020-0

Cited by 16 publications

(37 citation statements)

References 39 publications

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“…(2012) demonstrated that circulating 25OHD 3 level was increased in gilts fed with 25OHD 3 on days −13 (224.3 vs 141.8 nmol/L), 46 (239.5 vs 139.3 nmol/L), and 89 (232.0 vs 145.5 nmol/L) of gestation compared with that of gilts fed with the control diet, and fetuses from gilts fed with 25OHD 3 had higher plasma 25OHD 3 concentration than the control group. As reported by a previous study in our lab, a correlation analysis of 25OHD 3 concentrations in sows, newborns (umbilical cord blood) and suckling piglets showed that adding 25OHD 3 to lactating sows increased serum 25OHD 3 concentration in the umbilical cord and suckling pigs ( Zhang et al., 2019a ). Zhou et al.…”

Section: Maternal 25ohd 3 Supplementation Use As a Means Of Improving Vitamin D Status Of Sow-offspring Pairssupporting

confidence: 75%

“…Although limited vitamin D metabolites can be transferred into milk ( Hollis and Wagner, 2004a ), the concentration of 25OHD 3 in milk is positively correlated with the concentration of 25OHD 3 in maternal serum ( Specker et al., 1985 ). The results of correlation analysis from our lab showed that change of 25OHD 3 concentration in maternal or neonatal serum was correlated to change of milk 25OHD 3 concentration during lactation ( R 2 = 0.82 to 0.86, P < 0.01) ( Zhang et al., 2019a ). Collectively, adding 25OHD 3 to sow diets could contribute to improvements of 25OHD 3 concentration in maternal and neonatal serum during lactation compared with the control group, thereby increasing vitamin D status of sows and their offspring.…”

Section: Maternal 25ohd 3 Supplementation Use As a Means Of Improving Vitamin D Status Of Sow-offspring Pairsmentioning

confidence: 92%

“… Seibel (2005) and Golub and Boesze-Battaglia (2007) reported that BALP accounts for more than 90% of the total ALP and is an important index associated with the calcification process of bone matrix. Recently, the results from our lab showed that maternal 25OHD 3 supplementation could increase BALP activity in the serum of sows and suckling piglets ( Zhang et al., 2019a ). The effects of maternal 25OHD 3 supplementation on osteocalcin (OC) and cross laps (CL) in sow serum during gestation and lactation were conducted by Weber et al.…”

Section: Function and Application Of 25ohd 3 In Diets For The Sow Industrymentioning

confidence: 99%

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Use of 25-hydroxyvitamin D3 in diets for sows: A review

Zhang

Piao

2021

Animal Nutrition

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Dietary supplementation with 25-hydroxyvitamin D 3 (25OHD 3 ), as an alternative source of vitamin D, is becoming increasingly popular due to its commercialization and more efficient absorbability. The addition of 25OHD 3 rather than its precursor vitamin D 3 can circumvent the 25-hydroxylation reaction in the liver, indicating that supplementation of 25OHD 3 can rapidly improve the circulating vitamin D status of animals. Emerging experiments have reported that maternal 25OHD 3 supplementation could increase sow performances and birth outcomes and promote circulating vitamin D status of sows and their offspring. Increased milk fat content was observed in many experiments; however, others demonstrated that adding 25OHD 3 to lactating sow diets increased the contents of milk protein and lactose. Although an inconsistency between the results of different experiments exists, these studies suggested that maternal 25OHD 3 supplementation could alter milk composition via its effects on the mammary gland. Previous studies have demonstrated that adding 25OHD 3 to sow diets could improve the mRNA expressions of insulin-induced gene 1 ( INSIG1 ) and sterol regulatory element-binding protein 1 ( SREBP1 ) in the mammary gland cells from milk and increase the mRNA expressions of acetyl-CoA carboxylase α ( ACCα ) and fatty acid synthase ( FAS ) in the mammary gland tissue. Maternal 25OHD 3 supplementation promotes skeletal muscle development of piglets before and after parturition, and improves bone properties including bone density and bone breaking force in lactating sows and their piglets. Interestingly, 25OHD 3 supplementation in sow diets could improve neonatal bone development via regulation of milk fatty acid composition related to bone metabolism and mineralization. In this review, we also discuss the effects of adding 25OHD 3 to sow diets on the gut bacterial metabolites of suckling piglets, and propose that butyrate production may be associated with bone health. Therefore, to better understand the nutritional functions of maternal 25OHD 3 supplementation, this paper reviews advances in the studies of 25OHD 3 for sow nutrition and provides references for practical application.

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Section: Maternal 25ohd 3 Supplementation Use As a Means Of Improving Vitamin D Status Of Sow-offspring Pairssupporting

confidence: 75%

Section: Maternal 25ohd 3 Supplementation Use As a Means Of Improving Vitamin D Status Of Sow-offspring Pairsmentioning

confidence: 92%

Section: Function and Application Of 25ohd 3 In Diets For The Sow Industrymentioning

confidence: 99%

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Use of 25-hydroxyvitamin D3 in diets for sows: A review

Zhang

Piao

2021

Animal Nutrition

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“…Generally, vitamin D 3 used to be the traditional form of vitamin D supplement for swine nutrition. After it is absorbed, vitamin D 3 is then transported via circulating blood to the liver, where it is hydroxylated to 25‐hydroxycholecalciferol (25OHD 3 ), and 1 α ,25‐dihydroxycholecalciferol [1 α ,25(OH) 2 D 3 ] produced mainly, but not exclusively, in the kidney via 1 α ‐hydroxylase 1,2 …”

Section: Introductionmentioning

confidence: 99%

“…Vitamin D 3 enhances the absorption of calcium (Ca) and phosphorus (P) and maintains optimal Ca and P homeostasis for bone mineralization and development 2 . In addition to the traditional function, it plays important roles in influencing the organism's immune system, antioxidant potential, and intestinal health 3‐5 .…”

Section: Introductionmentioning

confidence: 99%

Dietary 25‐hydroxycholecalciferol supplementation improves performance, immunity, antioxidant status, intestinal morphology, and bone quality in weaned piglets

2020

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BACKGROUND 25‐Hydroxycholecalciferol (25OHD3) is a new feed additive, which is a potential alternative to vitamin D3 in swine nutrition. The objective of this study was to determine the effects of different doses of 25OHD3 supplementation on performance, immunity, antioxidant capacity, intestinal morphology and bone quality in piglets. RESULTS As dietary 25OHD3 supplementation increased, the average daily gain (ADG) improved (P < 0.05) quadratically during days 1–14, and tended to increase (P = 0.06) quadratically during the overall period of the experiment. Increasing 25OHD3 supplementation increased (linear effect, P < 0.05) the serum 25OHD3 level and serum glutathione peroxidase (GSH‐Px) activity. On day 14, serum immunoglobulin A (IgA) was increased (linear and quadratic effects, P < 0.05) as dietary 25OHD3 supplementation increased. On day 28, serum IgA level was higher (P < 0.05) linearly and the complement 3 (C3) level was reduced (P < 0.05) linearly as dietary supplementation of 25OHD3 increased. The mucosal GSH‐Px activity of the small intestine was higher (quadratic effect, P < 0.05) with increasing 25OHD3 supplementation. Jejunal villus height (P = 0.06) and villus height to crypt depth ratio (P = 0.07) tended to increase quadratically, and the villus height to crypt‐depth ratio of the ileum increased (P < 0.05) linearly and quadratically with increasing 25OHD3 supplementation. Dietary supplementation with an increasing level of 25OHD3 increased breaking strength of tibias and femurs (quadratic effect, P < 0.05). CONCLUSION Increasing dietary 25OHD3 supplementation partly improved performance, immunity, antioxidant status, intestinal morphology, and bone properties of weaned piglets. © 2020 Society of Chemical Industry

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Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

2021

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BACKGROUND: With the development of intensive farming, long-term exposure of pigs to poor light conditions is not conducive to the production of vitamin D 3 , and vitamin D 3 deficiency could affect absorption and metabolism of calcium (Ca) and phosphorus (P). 25-Hydroxyvitamin D 3 (25OHD 3 ) has higher bioactivity than regular vitamin D 3 . This study investigated the effects of 25OHD 3 on performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed with low Ca-P diet.RESULTS: It was found that a low Ca-P diet supplemented with 50 ∼g/kg 25OHD 3 (NC + 25-D) improved (P < 0.05) average daily gain (ADG) in phase 2 and in the overall period of the experiment, and increased (P < 0.05) the immunoglobulin G (IgG), immunoglobulin A (IgA), catalase (CAT), bone-specific alkaline phosphatase (BALP), and osteocalcin (OC) serum content on day 28 compared with a low Ca-P diet (NC), but no differences were observed between a normal Ca-P diet (PC) and the NC + 25-D diet. Compared with NC, the abundance of Firmicutes was higher (P < 0.05) in PC and NC + 25-D. NC + 25-D decreased (P < 0.05) the abundance of Streptococcaceae compared with PC and NC, and increased (P < 0.05) the abundance of Lachnospiraceae compared with NC. Serum 25OHD 3 was negatively correlated with the abundance of fecal Streptococcaceae (P < 0.05), and positively correlated with the abundance of fecal Lachnospiraceae (P < 0.05).CONCLUSION: Supplementation of 25OHD 3 in a low Ca-P diet improved serum immunity, bone biochemical parameters, and fecal microbiota such as decreased Streptococcaceae abundance and increased Lachnospiraceae abundance, which could subsequently promote growth of piglets. The effects were similar to that of a normal Ca-P diet.

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Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs

Cited by 16 publications

References 39 publications

Use of 25-hydroxyvitamin D3 in diets for sows: A review

Use of 25-hydroxyvitamin D3 in diets for sows: A review

Dietary 25‐hydroxycholecalciferol supplementation improves performance, immunity, antioxidant status, intestinal morphology, and bone quality in weaned piglets

Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

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Maternal 25-hydroxycholecalciferol during lactation improves intestinal calcium absorption and bone properties in sow-suckling piglet pairs

Cited by 16 publications

References 39 publications

Use of 25-hydroxyvitamin D3 in diets for sows: A review

Use of 25-hydroxyvitamin D3 in diets for sows: A review

Dietary 25‐hydroxycholecalciferol supplementation improves performance, immunity, antioxidant status, intestinal morphology, and bone quality in weaned piglets

Effects of 25‐hydroxyvitamin D3 on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus

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Effects of 25‐hydroxyvitamin D₃ on growth performance, serum parameters, fecal microbiota, and metabolites in weaned piglets fed diets with low calcium and phosphorus