Maternal age and initial β-hCG levels predict pregnancy outcome after single vitrified-warmed blastocyst transfer

Ueno, Satoshi; Ezoe, Kenji; Abe, Takashi; Yabuuchi, Akiko; Uchiyama, Kazuo; Okuno, Takashi; Kobayashi, Tamotsu; Kato, Keiichi

doi:10.1007/s10815-014-0273-5

Cited by 23 publications

(14 citation statements)

References 27 publications

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“…We recommend that each clinic determine its own threshold as HCG thresholds may vary between different clinics. Models for predicting pregnancy have been carried out separately for single fresh blastocyst transfers (Ochsenkuhn et al, 2009), or single vitrified-warmed blastocyst (Ueno et al, 2014) or for both fresh and vitrified-warmed blastocysts (Homan et al, 2000). Our study covered only single fresh or vitrified-warmed blastocyst transfers in a single centre using the same study population, laboratory culture and vitrification conditions.…”

Section: Discussionmentioning

confidence: 99%

Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer

Oron

Shavit

Esh-Broder

et al. 2017

Reproductive BioMedicine Online

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Possible differences between serum HCG levels in pregnancies achieved after transfer of a single fresh or a vitrified-warmed blastocyst were evaluated. Out of 1130 single blastocyst transfers resulting in positive HCG results, 789 were single fresh blastocyst transfers and 341 single vitrified-warmed blastocyst transfers. The initial serum HCG levels of 869 clinical intrauterine pregnancies were evaluated, 638 after the transfer of a single fresh blastocysts and 231 after the transfer of a single vitrified-warmed blastocysts. The HCG levels from cycles resulting in a clinical intrauterine pregnancy were significantly higher after the transfer of a single vitrified-warmed blastocyst (383 ± 230 IU/l) versus a fresh transfer (334 ± 192 IU/l; P = 0.01). Threshold values for predicting a clinical pregnancy for a fresh blastocyst were 111 IU/l and for a vitrified-warmed blastocyst 137 IU/l. Our study shows that the overall beta-HCG levels are comparable after the transfer of a fresh or vitrified-warmed blastocyst, suggesting that vitrification most probably does not affect the ability of the embryos to produce beta-HCG. This study further shows that when clinicians counsel patients, they should take into account that higher HCG levels are needed after a vitrified-warmed blastocyst transfer to predict a clinical intrauterine pregnancy.

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Section: Discussionmentioning

confidence: 99%

Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer

Oron

Shavit

Esh-Broder

et al. 2017

Reproductive BioMedicine Online

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show abstract

“…Pingping Qiu et al [28] reported that the concentration of serum β-HCG on day 10 were associated with the outcomes of vitrified-warmed blastocyst transplantation at different ages. Many models have been built to predict the pregnancy outcomes based on the serum hCG values [29][30][31][32]. Our findings provide a new idea for the study and prediction of the pregnancy outcomes after IVM, and can better help us to understand the hCG values after IVM treatment.…”

Section: Discussionmentioning

confidence: 79%

Positive Association of the Number of Oocyte Retrieved with the Maternal hCG Concentration in Early Pregnancy Achieved by Vitrified-Warmed Embryo Transfer after In Vitro Maturation

Wang¹,

Lin²,

Zheng³

et al. 2022

Clin. Exp. Obstet. Gynecol.

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Background: Human chorionic gonadotropin (hCG) is synthesized by trophoblast cells and play a critical effect in early pregnancy. The serum hCG concentration is significantly higher in early gestation period achieved through in vitro maturation (IVM) than that by traditional IVF. Since IVM does not involve ovarian hyperstimulation, we wonder whether the number of oocyte retrieved affect the hCG concentration in early pregnancy achieved by IVM. Methods: The retrospective analysis involved 51 women who delivered singletons were analyzed. The number of oocyte retrieved and the maternal hCG concentration were collected and analyzed. Results: 51 women had delivered singletons through IVM. The mean number of oocytes retrieved was 16.78 ± 11.23, and the hCG concentration was 614.47 ± 445.50 IU/L and 10930.20 ± 7223.17 IU/L at day 14 and 21, respectively. After confounding factors adjusted, the concentration of serum hCG at day 14 and 21 associated significantly with the number of oocyte retrieved. The result of crude linear regression analysis exhibited a positive relationship between the number of oocyte retrieved and the hCG concentration in early gestation. Conclusions: Our results suggested that the number of oocyte retrieved associated positively with the serum hCG level in female with early pregnancies that underwent IVM.

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“…In addition, in cases with insufficient luteal function (progesterone level on the day of SVBT <11 ng/ml), progesterone was administered intravaginally (Lutinus, Ferring Pharmaceuticals, Saint Prex, Switzerland) until the ninth week of pregnancy. Implantation was defined by serum hCG level (>20 IU/ml), in accordance with a previous study ( Ueno et al , 2014 ). The clinical and ongoing pregnancy rates were defined according to the ultrasonographic observation of a gestational sac 3 weeks after SVBTs and the observation of a foetal heartbeat 5 weeks after SVBTs, respectively ( Ezoe et al , 2020 ).…”

Section: Methodsmentioning

confidence: 96%

Endometrial thickness on the day of the LH surge: an effective predictor of pregnancy outcomes after modified natural cycle-frozen blastocyst transfer

Onogi¹,

Ezoe²,

Nishihara³

et al. 2020

Human Reproduction Open

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STUDY QUESTION Can the endometrial thickness (EMT) on the day of the LH surge predict pregnancy outcomes after single vitrified-warmed blastocyst transfers (SVBTs) in modified natural cycles? SUMMARY ANSWER Decreased EMT on the day of the LH surge is associated with older female age and a shortened proliferation phase and may be associated with low live birth and high chemical pregnancy rates. WHAT IS KNOWN ALREADY The relation between EMT on the day of embryo transfer (ET) and pregnancy outcomes remains controversial; although numerous studies reported an association between decreased EMT on the day of ET and a reduced likelihood of pregnancy, recent studies demonstrated that the EMT on the day of ET had limited independent prognostic value for pregnancy outcomes after IVF. The relation between EMT on the day of the LH surge and pregnancy outcomes after SVBT in modified natural cycles is currently unknown. STUDY DESIGN, SIZE, DURATION In total, 808 SVBTs in modified natural cycles, performed from November 2018 to October 2019, were analysed in this retrospective cohort study. Associations of EMT on the days of the LH surge with SVBT and clinical and ongoing pregnancy rates were statistically evaluated. Clinical and ongoing pregnancy rates were defined as the ultrasonographic observation of a gestational sac 3 weeks after SVBTs and the observation of a foetal heartbeat 5 weeks after SVBTs, respectively. Similarly, factors potentially associated with the EMT on day of the LH surge, such as patient and cycle characteristics, were investigated. PARTICIPANTS/MATERIALS, SETTING, METHODS The study includes IVF/ICSI patients aged 24–47 years, who underwent their first SVBT in the study period. After monitoring follicular development and serum hormone levels, ovulation was triggered via a nasal spray containing a GnRH agonist. After ovulation was confirmed, SVBTs were performed on Day 5. The EMT was evaluated by transvaginal ultrasonography on the day of the LH surge and immediately before the SVBT procedure. MAIN RESULTS AND THE ROLE OF CHANCE Of the original 901 patients, 93 who were outliers for FSH or proliferative phase duration data were excluded from the analysis. Patients were classified according to quartiles of EMT on day of the LH surge, as follows: EMT < 8.1 mm, 8.1 mm ≤ EMT < 9.1 mm, 9.1 mm ≤ EMT < 10.6 mm and EMT ≥ 10.6 mm. Decreased EMT on day of the LH surge was associated with lower live birth ( P = 0.0016) and higher chemical pregnancy ( P = 0.0011) rates. Similarly, patients were classified according to quartiles of EMT on day of the SVBT, as follows: EMT < 9.1 mm, 9.1 mm ≤ EMT < 10.1 mm, 10.1 mm ≤ EMT < 12.1 mm and EMT ≥ 12.1 mm. A decreased EMT on the day of SVBT was associated with a lower live birth rate ( P = 0.0095) but not chemical pregna...

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Maternal age and initial β-hCG levels predict pregnancy outcome after single vitrified-warmed blastocyst transfer

Cited by 23 publications

References 27 publications

Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer

Predictive value of serum HCG concentrations in pregnancies achieved after single fresh or vitrified-warmed blastocyst transfer

Positive Association of the Number of Oocyte Retrieved with the Maternal hCG Concentration in Early Pregnancy Achieved by Vitrified-Warmed Embryo Transfer after In Vitro Maturation

Endometrial thickness on the day of the LH surge: an effective predictor of pregnancy outcomes after modified natural cycle-frozen blastocyst transfer

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