Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR) II. Inhibition of priming by placental extracts

Voisin, J.; Kinský, R; Voisin, G A

doi:10.1016/0165-0378(86)90002-1

Cited by 17 publications

(6 citation statements)

References 10 publications

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“…For instance, it has been shown that the administration of placental extract in lymphocytes results in a cytostatic response and inhibition of responses to mitogenic stimuli [26]. In addition, by affecting T lymphocytes, placental extract is capable of inhibiting graft-versus-host disease and allogenic mixed lymphocyte reaction [27,28]. Placental extract may further inhibit B cells activity because the secretion of antibody against immunized antigen is suppressed in the presence of placental extract [29].…”

Section: Open Accessmentioning

confidence: 99%

Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease?

Jazayeri

Barzaman

Aghaie

et al. 2020

Autoimmun Highlights

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Background Different studies have demonstrated the anti-inflammatory effects of human placental extract both in vivo and in vitro. Considering the chronic inflammatory nature of multiple sclerosis (MS) disease, we examined whether or not the administration of human placental extract is able to attenuate the neurological symptoms detected in experimental autoimmune encephalomyelitis (EAE) model of MS. Methods The injected myelin oligodendrocyte glycoprotein (MOG) induced EAE in mice, and treatment began from day 4 post-injection by intraperitoneal administration of 0.2 mg/kg human placental extract, repeated every other day up to day 31 post-injection. At the end of the treatment, luxol fast blue (LBS) staining and hematoxylin and eosin (H&E) staining were performed to evaluate the demyelination of neurons and inflammatory responses, respectively. Further assessed were the serum concentrations of IL-23 and IL-27. Results The administration of human placental extract was able to significantly reduce the mean clinical score in EAE mice, decrease the pro-inflammatory process and attenuate neural demyelination. Moreover, while the serum concentration of IL-23 was significantly diminished in the EAE mice receiving human placental extract compared to the non-treated EAE group, IL-27 concentration was significantly increased. Conclusions Our findings demonstrated the administration of human placental extract could significantly attenuate the neurological symptoms in the EAE model of MS in part through modulating the serum levels of IL-23 and IL-27 and enhancing neuroprotection and myelin repair.

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Section: Open Accessmentioning

confidence: 99%

Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease?

Jazayeri

Barzaman

Aghaie

et al. 2020

Autoimmun Highlights

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“…Lymphocyte responses to mitogenic stimuli are inhibited by the addition of placental extract in a dose-dependent manner, mainly due to a cytostatic effect [16]. Allogeneic mixed lymphocyte reaction and graft-versus-host disease is also inhibited by placental extract [17, 18], suggesting that T lymphocyte is a potential target of the inhibitory effects. In addition, B cell functions could be also affected, as antibody (Ab) responses to the immunized antigen (Ag) are suppressed by placental extract [19].…”

Section: Introductionmentioning

confidence: 99%

Preventive and therapeutic potential of placental extract in contact hypersensitivity

Kim

Park

Sakoda

et al. 2010

International Immunopharmacology

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Immunoregulatory effects of placental extract and placenta-derived factors have been demonstrated in various conditions. Accordingly, placental extract has been used as certain types of medical intervention in Asian countries, whereas experimental evidence supporting its therapeutic effects and mechanisms has yet to be fully demonstrated. In this study, we investigate preventive and therapeutic effects of placental extract in contact hypersensitivity (CHS), a mouse model of allergic contact dermatitis. Administration of placental extract prior to the sensitization of allergic antigen (Ag) significantly inhibited the severity of CHS induced by Ag challenge. This effect was associated with reduced numbers of CD4+ T cells in peripheral blood, decrease of tissue-infiltrating lymphocytes, and preferential production of Th2-type cytokines in Ag-challenged sites. In addition, CHS caused by repetitive challenges of allergic Ag was also prevented and treated by administration of placental extract. Finally, administration of cyclo-trans-4-Lhydroxyprolyl-L-serine, a dipeptide derived from placental extract, also alleviated CHS, suggesting its potential role in the effects of placental extract in CHS. Taken together, our findings demonstrated experimental evidence supporting immunoregulatory effects of placental extract in allergic skin diseases and elucidated its potential mechanisms.

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“…Multiple studies have demonstrated that HPE is also involved in immune regulation. HPE retards graft-versus-host diseases (GVHD) which are associated with T lymphocytes by inducing the redistribution of regulatory T (Treg) cells [14,15]. HPE suppress allergic airway in ammation and potentiate induction of regulatory T cells in a murine model of allergic rhinitis [15].…”

Section: Introductionmentioning

confidence: 99%

Human placental extracts suppress mast cell activation and induce mast cell apoptosis

Yan

et al. 2022

Preprint

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Background Human placental extracts (HPE) have been documented to facilitate the healing of certain disorders including allergy. However, the effects of HPE on the functionality of mast cells, a critical cell type in allergic diseases, have not been reported. Methods To investigate the effects of HPE on the regulation of allergy with respect to the biological functions of mast cells, the mast cell line C57 cells were treated with HPE followed by the assessment of cell proliferation, apoptosis, activation, chemotaxis and phagocytosis. Mouse peritoneal mast cells were also investigated for their responses to induction of apoptosis by HPE in vivo. Furthermore, the effect of HPE on mast cell degranulation was confirmed using the passive cutaneous anaphylaxis (PCA) assay, an acute allergy model. Results HPE was capable of suppressing mast cell proliferation and inducing mast cell apoptosis. Mast cell degranulation in response to compound 48/80- or anti-DNP IgE and DNP-mediated activation was suppressed. In addition, treatment with HPE compromised the production of cytokines by mast cells and cell chemotaxis. These observations were consistent with the dampened passive cutaneous anaphylaxis (PCA) assay following treatment with HPE. Conclusion This study revealed a suppressive effect of HPE on overall mast cell activities, suggesting a potential regulatory role of HPE on the alleviation of allergic diseases through mast cells.

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Maternal alloimmune reactions towards the murine conceptus and graft-versus-host reaction (GVHR) II. Inhibition of priming by placental extracts

Cited by 17 publications

References 10 publications

Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease?

Human placental extract attenuates neurological symptoms in the experimental autoimmune encephalomyelitis model of multiple sclerosis-a putative approach in MS disease?

Preventive and therapeutic potential of placental extract in contact hypersensitivity

Human placental extracts suppress mast cell activation and induce mast cell apoptosis

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