Maternal Antimüllerian Hormone as a Predictor of Euploid Is Independently Associated With Cumulative Live Birth Rates

Abstract

Background: Serum antimÜllerian hormone (AMH) level has been reported to be associated with pregnancy rates after assisted reproduction. It is unclear whether AMH levels affect number of euploid blastocysts and cumulative live birth rates (CLBR). The aim of this study was to investigate whether AMH levels are associated with cumulative live birth rates (CLBR) through their relationship with oocyte quality.Methods: A total of 975 consecutive infertile women undergoing 1825 preimplantation genetic screening (PGS) analysis. Serum AMH levels were measured by AMH Gen II assay kit within the 3 months before Controlled Ovarian Hyperstimulation. Embryos were cultured and biopsied at the blastocyst stage. Results: Among 975 women undergoing PGS analysis. Age, serum AMH and number of oocytes retrieved were significantly and independently related to number of euploid blastocysts available for patients to transfer (P < .001). in patients displaying superior serum AMH levels, cumulative live birth rates (CLBR) were significantly increased independently from age and number of oocytes retrieved (P < .001), and this group with lower AMH levels also showed increased pregnancy loss rates.Conclusions: Serum AMH levels are positively age-independent associated with cumulative live birth rates after all viable embryos are transferred from the first ovarian stimulation cycle. And embryonic euploidy outcome was superior in patients with higher AMH levels. These present findings confirm that serum AMH levels might reflect not only ovarian reserve but also qualitative aspects of oocytes, which will effect the clinical application of PGS.