Maternal Diet and Exercise: Influences on Obesity and Insulin Resistance

Carter, Lindsay; Tamashiro, Kellie L.K.

doi:10.1201/b17530-4

Cited by 2 publications

(1 citation statement)

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“…23,27 Using the same stock of mice in our voluntary exercise study, we detected significant improvements in only the male offspring by 1 year of age, 17 though the females showed a strong trend toward improvement at ~16 months of age. 40 Importantly, the maternal intervention applied herein was mild in terms of speed and duration of exercise compared to free-choice running studies, and a longer duration or more intense exercise might have greater impact on offspring glucose tolerance and body composition. Future studies using more aggressive exercise stimuli are warranted.…”

Section: Discussionmentioning

confidence: 99%

Effects of maternal controlled exercise on offspring adiposity and glucose tolerance

Platt

Przybylowski

Charnigo

et al. 2021

J Dev Orig Health Dis

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While metabolic disorders such as obesity and diabetes are costly and deadly to the current population, they are also extremely detrimental to the next generation. Much of the current literature focuses on the negative impact of poor maternal choices on offspring disease, while there is little work examining maternal behaviors that may improve offspring health. Research has shown that voluntary maternal exercise in mouse models improves metabolic function in offspring. In this study, we hypothesized that controlled maternal exercise in a mouse model will effect positive change on offspring obesity and glucose homeostasis. Female mice were separated into three groups: home cage, sedentary, and exercise. The sedentary home cage group was not removed from the home cage, while the sedentary wheel group was removed from the cage and placed in an immobile wheel apparatus. The exercise group was removed from the home cage and run on the same wheel apparatus but with the motor activated at 5–10 m/min for 1 h/d prior to and during pregnancy. Offspring were subjected to oral glucose tolerance testing and body composition analysis. There was no significant difference in offspring glucose tolerance or body composition as a consequence of the maternal exercise intervention compared to the sedentary wheel group. There were no marked negative consequences of the maternal controlled exercise intervention. Further research should clarify the potential advantages of the controlled exercise model and improve experimental techniques to facilitate translation of this research to human applications.

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Section: Discussionmentioning

confidence: 99%