Maternal DNA Methylation in Second Half of Pregnancy in Th1, Th2, Th17 and Treg Pathway Genes Differs with Birth-Order

Nilormee, Orpita; Lockett, Gabrielle A.; Iqbal, Sabrina; Holloway, John W.; Arshad, Syed Hasan; Zhang, Hongmei; Karmaus, Wilfried

doi:10.1016/j.jaci.2016.12.898

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“…This study suggests that DNA methylation tends to be more consistent and stabilized for later born infants, subsequent to prior deliveries; however, this study did not examine the directionality of DNA methylation alterations after twin pregnancies. In another candidate gene study 20 , the DNA methylation of genes in T-cell pathways were reported to be associated with birth order, and they could in turn affect immune functions of the newborn. However, these studies had small sample sizes and could not detect DNA methylation changes with birth order on a wider genomic scale.…”

Section: Introductionmentioning

confidence: 99%

A Pregnancy and Childhood Epigenetics Consortium (PACE) meta-analysis highlights potential relationships between birth order and neonatal blood DNA methylation

Li,

Spitz,

Ghantous

et al. 2024

Commun Biol

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Higher birth order is associated with altered risk of many disease states. Changes in placentation and exposures to in utero growth factors with successive pregnancies may impact later life disease risk via persistent DNA methylation alterations. We investigated birth order with Illumina DNA methylation array data in each of 16 birth cohorts (8164 newborns) with European, African, and Latino ancestries from the Pregnancy and Childhood Epigenetics Consortium. Meta-analyzed data demonstrated systematic DNA methylation variation in 341 CpGs (FDR adjusted P < 0.05) and 1107 regions. Forty CpGs were located within known quantitative trait loci for gene expression traits in blood, and trait enrichment analysis suggested a strong association with immune-related, transcriptional control, and blood pressure regulation phenotypes. Decreasing fertility rates worldwide with the concomitant increased proportion of first-born children highlights a potential reflection of birth order-related epigenomic states on changing disease incidence trends.

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Section: Introductionmentioning

confidence: 99%