Maternal exposure to air pollution and type 1 diabetes – Accounting for genetic factors

Malmqvist, Ebba; Larsson, Helena Elding; Jönsson, Ida; Rignell-Hydbom, Anna; Ivarsson, Sten-Anders; Tinnerberg, Håkan; Stroh, Emilie; Rittner, Ralf; Jakobsson, Kristina; Swietlicki, Erik; Rylander, Lars

doi:10.1016/j.envres.2015.03.024

Cited by 58 publications

(39 citation statements)

References 29 publications

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“…In line with this observation, associations between air pollution exposures at the place of residence and liver enzymes have also been observed [106]. Immunomodulatory effects of outdoor air pollution are further hypothesised to promote an earlier onset of type 1 diabetes [107, 108]. Clearly, development of these systemic/metabolic outcomes would be considered adverse, as per consideration 2 (persistence) in table 1; however, their associations with air pollution are not sufficiently robust at this time to consider them to be adverse effects of air pollution.…”

Section: Emerging Adverse Effects Of Outdoor Air Pollutionmentioning

confidence: 86%

A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework

et al. 2016

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The American Thoracic Society has previously published statements on what constitutes an adverse effect on health of air pollution in 1985 and 2000. We set out to update and broaden these past statements that focused primarily on effects on the respiratory system. Since then, many studies have documented effects of air pollution on other organ systems, such as on the cardiovascular and central nervous systems. In addition, many new biomarkers of effects have been developed and applied in air pollution studies. This current report seeks to integrate the latest science into a general framework for interpreting the adversity of the human health effects of air pollution. Rather than trying to provide a catalogue of what is and what is not an adverse effect of air pollution, we propose a set of considerations that can be applied in forming judgments of the adversity of not only currently documented, but also emerging and future effects of air pollution on human health. These considerations are illustrated by the inclusion of examples for different types of health effects of air pollution.

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Section: Emerging Adverse Effects Of Outdoor Air Pollutionmentioning

confidence: 86%

A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework

et al. 2016

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“…More importantly, our data show no peripheral insulin resistance in the muscle or liver after ozone exposure. Incidentally, exposure to ozone has been associated with TID in pregnancy and in children (Hathout et al, 2002, 2006; Beyerlein et al, 2015; Malmqvist et al, 2015). Our data show that insulin resistance is not the cause of ozone-induced hyperglycemia, glucose intolerance, or the activation of gluconeogenesis observed in our study.…”

Section: Discussionmentioning

confidence: 99%

Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats

Miller

Snow

Henriquez

et al. 2016

Toxicology and Applied Pharmacology

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Acute ozone exposure induces a classical stress response with elevated circulating stress hormones along with changes in glucose, protein and lipid metabolism in rats, with similar alterations in ozone-exposed humans. These stress-mediated changes over time have been linked to insulin resistance. We hypothesized that acute ozone-induced stress response and metabolic impairment would persist during subchronic episodic exposure and induce peripheral insulin resistance. Male Wistar Kyoto rats were exposed to air or 0.25 ppm or 1.00 ppm ozone, 5 h/day, 3 consecutive days/week (wk) for 13 wks. Pulmonary, metabolic, insulin signaling and stress endpoints were determined immediately after 13 wk or following a 1 wk recovery period (13 wk + 1 wk recovery). We show that episodic ozone exposure is associated with persistent pulmonary injury and inflammation, fasting hyperglycemia, glucose intolerance, as well as, elevated circulating adrenaline and cholesterol when measured at 13 wk, however, these responses were largely reversible following a 1 wk recovery. Moreover, the increases noted acutely after ozone exposure in non-esterified fatty acids and branched chain amino acid levels were not apparent following a subchronic exposure. Neither peripheral or tissue specific insulin resistance nor increased hepatic gluconeogenesis were present after subchronic ozone exposure. Instead, long-term ozone exposure lowered circulating insulin and severely impaired glucose-stimulated beta-cell insulin secretion. Thus, our findings in young-adult rats provide potential insights into epidemiological studies that show a positive association between ozone exposures and type 1 diabetes. Ozone-induced beta-cell dysfunction may secondarily contribute to other tissue-specific metabolic alterations following chronic exposure due to impaired regulation of glucose, lipid, and protein metabolism.

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“…For example, prenatal exposure to even low levels of air pollution in Sweden were positively associated with T1DM development in children,9 while exposure to nitrate and nitrite may be diabetogenic only at higher levels of exposure 6. Most experimental studies on EDCs and T1DM thus far involve higher doses, but some low dose studies also show harmful effects.…”

Section: Resultsmentioning

confidence: 99%

“…It found that the children of mothers who lived at residences with higher levels of air pollution (nitrogen oxides [NO x ] and ozone) had a higher risk of developing T1DM by 8–14 years of age 9. For NO x , the association was significant for third trimester exposures, and for ozone, for second trimester exposures.…”

Section: Air Pollutionmentioning

confidence: 99%

Exposure to environmental chemicals and type 1 diabetes: an update

Howard

2019

J Epidemiol Community Health

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This narrative review summarises recently published epidemiological and in vivo experimental studies on exposure to environmental chemicals and their potential role in the development of type 1 diabetes mellitus (T1DM). These studies focus on a variety of environmental chemical exposures, including to air pollution, arsenic, some persistent organic pollutants, pesticides, bisphenol A and phthalates. Of the 15 epidemiological studies identified, 14 include measurements of exposures during childhood, 2 include prenatal exposures and 1 includes adults over age 21. Together, they illustrate that the role of chemicals in T1DM may be complex and may depend on a variety of factors, such as exposure level, timing of exposure, nutritional status and chemical metabolism. While the evidence that these exposures may increase the risk of T1DM is still preliminary, it is critical to investigate this possibility further as a means of preventing T1DM.

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Maternal exposure to air pollution and type 1 diabetes – Accounting for genetic factors

Cited by 58 publications

References 29 publications

A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework

A joint ERS/ATS policy statement: what constitutes an adverse health effect of air pollution? An analytical framework

Systemic metabolic derangement, pulmonary effects, and insulin insufficiency following subchronic ozone exposure in rats

Exposure to environmental chemicals and type 1 diabetes: an update

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