Maternal Exposure to Per- and Polyfluoroalkyl Substances: Implications for Intrahepatic Cholestasis of Pregnancy and Adverse Birth Outcomes

Tian, Yonghong; Xu, Chenye; Zhang, Long; Shi, Dake; Cappelli, Francesca; Yin, Shanshan

doi:10.1007/s12403-023-00620-6

Expo Health

2024

DOI: 10.1007/s12403-023-00620-6

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Maternal Exposure to Per- and Polyfluoroalkyl Substances: Implications for Intrahepatic Cholestasis of Pregnancy and Adverse Birth Outcomes

Yonghong Tian,

Chenye Xu,

Long Zhang

et al.

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2024

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Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots

Galletto,

Ververi,

Massano

et al. 2024

Anal Bioanal Chem

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Per- and polyfluoroalkyl substances (PFAS) are anthropogenic fluorine-containing compounds largely used in industrial and consumer applications. They tend to bioaccumulate in the human body after intake from various sources in daily life. Following repeated exposure to PFAS, a broad range of adverse health outcomes has been reported. Consequently, monitoring PFAS levels in human blood is of paramount importance for public health policies. In contrast with traditional venipuncture, dried blood spots (DBS) constitute a reliable, cheap, and less invasive technique to allow microsampling by capillary blood collected on a specific device. This work aimed to develop and validate an innovative analytical method, combining quantitative DBS with UHPLC-MS/MS instrumentation to identify and quantify 25 PFAS. The extraction procedure was developed and optimized within the range 2–100 ng/mL. Specifically, fortified blood was applied on Capitainer®B devices providing 10 μL of blood volume through a microfluidic channel. After 3 h of drying, the extraction was performed by methanol under sonication, followed by centrifugation. Then, the extraction solvent was evaporated; the residue was reconstituted with the mobile phase solution. The validated method evidenced good sensitivity, with limits of detection ranging from 0.4 ng/mL (PFODA, PFOS) to 1.0 ng/mL (PFOA, 3,6-OPFHpA). The ± 20% acceptability criteria established for intra- and inter-day precision and accuracy were fulfilled for all analytes. High recovery—above 80%—was recorded, whereas significant matrix effect resulted in ion enhancement (> 50%) for 13 analytes. In conclusion, the proposed workflow proved to be reliable, fit for purpose, and easily adaptable in the laboratory routine. Graphical Abstract

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Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots

Galletto,

Ververi,

Massano

et al. 2024

Anal Bioanal Chem

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show abstract

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Maternal Exposure to Per- and Polyfluoroalkyl Substances: Implications for Intrahepatic Cholestasis of Pregnancy and Adverse Birth Outcomes

Cited by 1 publication

References 84 publications

Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots

Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots

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