Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings

Liu, Yun; Peterson, Karen E.

doi:10.1007/s40572-015-0068-6

Cited by 43 publications

(41 citation statements)

References 62 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Two recent systematic reviews focused on the association of BPA with indicators of obesity and BPA with the risk of cardiometabolic disorders in adults (52, 53). Another review considered the epidemiologic studies examining the impacts of maternal exposure to synthetic chemicals (eg, BPA and phthalates) and obesity in the offspring (5). BPA is used in a variety of products including medical equipment, food can linings, food/beverage storage containers, toys, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Phthalates are used in a wide range of consumer products including cosmetics, personal care products, and plastics (5). Because of increasing scientific research and public concern about the toxicity of PAEs, various regulatory actions are directed at restricting the use of certain phthalates in consumer products, particularly those concerning infants and children.…”

Section: Discussionmentioning

confidence: 99%

“…The number of infants and preschool children who were overweight and obese worldwide increased from 32 million in 1990 to 42 million in 2013, and this total is estimated to increase to 70 million by 2025 (5). Of concern, obese children and adolescents are at a high risk for chronic disorders including type 2 diabetes, osteoarthritis, cancer, and cardiovascular disease (6).…”

Section: Contextmentioning

confidence: 99%

See 2 more Smart Citations

Association of Endocrine Disrupting Chemicals, Bisphenol A and Phthalates, with Childhood Obesity: A Systematic Review

et al. 2017

View full text Add to dashboard Cite

Context: Exposure to endocrine-disrupting chemicals (EDCs) can contribute to the risk of childhood and adolescent obesity. Objectives: The aim of this study was to systematically review the literature concerning the association of bisphenol A (BPA) and phthalates with obesity in children and adolescents.Data Sources: Scopus, ISI Web of Science, PubMed, Google Scholar, and Medline were searched to identify studies published up to January 2017. A secondary reference review of all extracted articles was also conducted.Study Selection: All studies that had assessed the relationship between BPA and phthalates with obesity in children and adolescents were included in the present systematic review. Finally, 35 studies were relevant.Data Extraction: The current review was conducted and reported in accordance with the Preferred Reporting Items for systematic reviews and meta-analyses (PRISMA) statement.Results: Thirty-five original studies met the inclusion criteria, consisting of 20 cross sectional, 3 case control, 11 cohort studies and one clinical trial study. Nineteen studies reported that childhood exposure to environmental chemicals including BPA and phthalic acid esters (PAEs) during childhood could increase the risk of excess weight. In addition, 10 studies found no correlation between these compounds and obesity. Conclusions:The effects of BPA and phthalates have diverse mechanisms; these chemicals disrupt some functional, structural, and epigenetic mechanisms that control energy homeostasis, appetite regulation, lipid metabolism, and adipogenesis. However, additional longitudinal studies are needed to confirm and validate the current findings.Keywords: Endocrine Disrupters, Bisphenol A, Phthalates, Obesity, Children ContextEndocrine disrupting chemicals (EDCs) are environmental chemicals that can interfere with different aspects of hormone action. Moreover, EDCs bind to hormone receptors and can repress, or activate and/or interfere with hormone metabolism and synthesis. EDCs act via nuclear receptors, nonnuclear steroid hormone receptors, orphan receptors, enzymatic pathways involved in steroid biosynthesis and/or metabolism, and several other mechanisms that converge upon endocrine controlled and reproductive systems (1). A growing body of evidence has focused attention on how the exposure to industrial compounds may interfere with the programming of complex endocrine pathways (2). EDCs are ubiquitous in environment; their main role on fetal life and childhood seems to be associated with the increasing rates of low birth weight, premature birth, disorders of sex development, and obesity. They might, also, affect the weight extent with other direct effects, particularly during childhood (3). Over the past decades, childhood obesity has emerged as a public health problem worldwide, even in developing countries (4).The number of infants and preschool children who were overweight and obese worldwide increased from 32 million in 1990 to 42 million in 2013, and this total is estimated to increase to 70 mill...

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Contextmentioning

confidence: 99%

See 1 more Smart Citation

Association of Endocrine Disrupting Chemicals, Bisphenol A and Phthalates, with Childhood Obesity: A Systematic Review

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Persistent organic pollutants (POPs) are a broad class of synthetic chemicals developed for industrial, agricultural, and/ or commercial applications that have known or suspected human toxicity, based on a growing body of animal and epidemiological studies (Baillie-Hamilton 2002;Di Renzo et al 2015;Diamanti-Kandarakis et al 2009;Elobeid and Allison 2008;Grant et al 2014;Liu and Peterson 2015;Loomis et al 2015;Newbold et al 2008;Schug et al 2011;TangPéronard et al 2011). They can last for years before degrading into less dangerous forms, travel long distances (e.g., through air, water, exported food, commercial products), and bioaccumulate in higher-order animals present in many diets, such as fish which tend to easily enrich POPs in their tissues (Geyer et al 2000;United Nations Environmental Programme 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Academic societies and international expert workshops have called for further investments into not only the identification of pollutant exposures, but also research on their health effects (Di Renzo et al 2015;Grandjean et al 2015). Recent reviews and commentaries have suggested that human exposure to POPs is adversely linked with a diverse array of outcomes that span the lifecourse, including childhood growth and development (Di Renzo et al 2015;Liu and Peterson 2015;Tang-Péronard et al 2011), fertility (Di Renzo et al 2015), pregnancy (Di Renzo et al 2015), diabetes (Grant et al 2014), and cancer (Loomis et al 2015). To date, most epidemiologic studies have focused on 'legacy POPs' including the polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) such as dichlorodiphenyltrichloroethane (DDT), whereas other pollutant groups have not been evaluated in terms of exposure patterns or associations with disease outcomes (World Health Organization 2012), with a notable lack of data from LMICs.…”

Section: Introductionmentioning

confidence: 99%

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

et al. 2018

View full text Add to dashboard Cite

Information about the human burdens of persistent organic pollutants (POPs) in low-and middle-income countries is limited. In particular, studies often include only a small subset of POPs. To address this data gap, we aimed to assess maternal-child exposures to POPs in Dhaka, Bangladesh. We quantified 16 organochlorine pesticides, 12 polychlorinated biphenyls, 21 brominated flame retardants, 18 per-and polyfluorinated alkyl substances, 2 polycyclic aromatic hydrocarbons, and short-chain chlorinated paraffins in 18 pooled samples of human cord blood from 90 mother-infant pairs living in Dhaka, Bangladesh (2014. In all pooled samples, we detected high levels of p,p′-DDT (median 81.6 ng/g lipid) and its metabolites p,p′-DDE and p,p′-DDD (median 551 and 10.7 ng/g lipid, respectively), where the p,p′-DDE/p,p′-DDT ratio ranged from 2.9 to 9.8 indicating recent dichlorodiphenyltrichloroethane (DDT) exposure. We also detected acenaphthene, decabromodiphenyl ethane, o,p′-DDT, o,p′-DDE, hexachlorobenzene, β-hexachlorocyclohexane, hexabromobenzene, and perfluorooctanoic acid in a subset of samples. For the other 59 target compounds, concentrations were below the limits of detection, despite using ultra-trace analytical methodology. No trends were observed when stratifying the analyses of detected POP concentrations by maternal age, maternal body mass index, or large fish consumption. These findings highlight recent DDT exposure in Dhaka, but the overall POP burden was otherwise low in this sample of pregnant women/newborns. Future monitoring efforts should focus on newly detected POPs for which burdens may be increasing due to ongoing industrialization in Bangladesh.

show abstract

The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

Mallozzi¹,

Bordi²,

Garo³

et al. 2016

Birth Defects Research Pt C

View full text Add to dashboard Cite

There is a widespread exposure of general population, including pregnant women and developing fetuses, to the endocrine disrupting chemicals (EDCs). These chemicals have been reported to be present in urine, blood serum, breast milk, and amniotic fluid. Endocrine disruptions induced by environmental toxicants have placed a heavy burden on society, since environmental exposures during critical periods of development can permanently reprogram normal physiological responses, thereby increasing susceptibility to disease later in life-a process known as developmental reprogramming. During development, organogenesis and tissue differentiation occur through a continuous series of tightly-regulated and precisely-timed molecular, biochemical, and cellular events. Humans may encounter EDCs daily and during all stages of life, from conception and fetal development through adulthood and senescence. Nevertheless, prenatal and early postnatal windows are the most critical for proper development, due to rapid changes in system growth. Although there are still gaps in our knowledge, currently available data support the urgent need for health and environmental policies aimed at protecting the public and, in particular, the developing fetus and women of reproductive age. Birth Defects Research (Part C) 108:224-242, 2016. © 2016 Wiley Periodicals, Inc.

show abstract

Maternal Exposure to Synthetic Chemicals and Obesity in the Offspring: Recent Findings

Cited by 43 publications

References 62 publications

Association of Endocrine Disrupting Chemicals, Bisphenol A and Phthalates, with Childhood Obesity: A Systematic Review

Association of Endocrine Disrupting Chemicals, Bisphenol A and Phthalates, with Childhood Obesity: A Systematic Review

Maternal-Child Exposures to Persistent Organic Pollutants in Dhaka, Bangladesh

The effect of maternal exposure to endocrine disrupting chemicals on fetal and neonatal development: A review on the major concerns

Contact Info

Product

Resources

About