Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Li, Shiying; Tse, Iris Mei Ying; Li, Edmund T.S.

doi:10.1016/j.jnutbio.2011.11.008

Cited by 35 publications

(25 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diet composition is closely related to energy efficiency. Mice with high-fat diet induced obese would have increased energy efficiency, partly resulting from the high energy content of triglycerides, which are stored in essentially anhydrous form other than the hydrated form for polysaccharides, reducing the energy stores’ efficiency as fuel [ 21 , 22 , 23 ]. In this study, an increase in energy efficiency has been observed in the HF group, while OXY1 diet (2.5 g OXY/kg HF diet) decreased energy efficiency in mice and normalized it to that of the low-fat diet group.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

Tan¹,

Tse²,

Li³

et al. 2017

Nutrients

View full text Add to dashboard Cite

Oxyresveratrol has been proven effective in inhibiting adipogenesis in a 3T3-L1 cell model. We investigated the preventive effect of oxyresveratrol supplementation on obesity development in high-fat diet-fed mice. Male C57bl/6 mice were randomly subjected to control (5% fat by weight, LF), high-fat (30% fat by weight, HF), and high-fat supplemented with 0.25% and 0.5% oxyresveratrol (OXY1 and OXY2, respectively) diet groups for eight weeks. Oxyresveratrol supplementation effectively alleviated obesity-associated symptoms such as insulin resistance, hyperglycemia, and hepatic steatosis in high-fat diet-fed mice. Compared to the high-fat diet group, oxyresveratrol supplementation suppressed expression of glucose-6-phosphatase, sterol regulatory element-binding proteins 1, fatty acid synthase and CCAAT/Enhancer-binding proteins α, and elevated AMP-activated protein kinase (α2-catalytic subunit) level in liver, upregulated insulin-dependent glucose transporter type 4 level in adipose tissue, and increased expression of insulin receptor substrate 1, insulin-dependent glucose transporter type 4, AMP-activated protein kinase α, peroxisome proliferator-activated receptor γ coactivator-1α, and sirtuin 1 in muscle to regulate lipid and glucose homeostasis in these tissues. This study demonstrated that oxyresveratrol supplementation effectively ameliorated obesity-associated symptoms in high-fat diet-fed mice, presumably attributed to mediating critical regulators involved in lipid and glucose homeostasis in liver, visceral fat, and muscle.

show abstract

Section: Discussionmentioning

confidence: 99%

“…7 Energy efficiency: body weight gain (g)/energy intake (MJ). Energy efficiency is calculated as described by Li et al [ 21 ].…”

Section: Figurementioning

confidence: 99%

Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

Tan¹,

Tse²,

Li³

et al. 2017

Nutrients

View full text Add to dashboard Cite

show abstract

“…The insulin resistance index (IRI) was calculated by the product of fasting insulin (µIU/mL) × fasting glucose (mmol/L) (Fagundes et al 2009, Lima Nda et al 2011, Li et al 2012.…”

Section: Plasmatic Parametersmentioning

confidence: 99%

HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats

Miranda

Torrezan

Oliveira

et al. 2016

Journal of Endocrinology

View full text Add to dashboard Cite

Neuroendocrine dysfunctions such as the hyperactivity of the vagus nerve and hypothalamus–pituitary–adrenal (HPA) axis greatly contribute to obesity and hyperinsulinemia; however, little is known about these dysfunctions in the pancreatic β-cells of obese individuals. We used a hypothalamic-obesity model obtained by neonatal treatment with monosodiuml-glutamate (MSG) to induce obesity. To assess the role of the HPA axis and vagal tonus in the genesis of hypercorticosteronemia and hyperinsulinemia in an adult MSG-obese rat model, bilateral adrenalectomy (ADX) and subdiaphragmatic vagotomy (VAG) alone or combined surgeries (ADX–VAG) were performed. To study glucose-induced insulin secretion (GIIS) and the cholinergic insulinotropic process, pancreatic islets were incubated with different glucose concentrations with or without oxotremorine-M, a selective agonist of the M3muscarinic acetylcholine receptor (M3AChR) subtype. Protein expression of M3AChR in pancreatic islets, corticosteronemia, and vagus nerve activity was also evaluated. Surgeries reduced 80% of the body weight gain. Fasting glucose and insulin were reduced both by ADX and ADX–VAG, whereas VAG was only associated with hyperglycemia. The serum insulin post-glucose stimulation was lower in all animals that underwent an operation. Vagal activity was decreased by 50% in ADX rats. In the highest glucose concentration, both surgeries reduced GIIS by 50%, whereas ADX-VAG decreased by 70%. Additionally, M3AChR activity was recovered by the individual surgeries. M3AChR protein expression was reduced by ADX. Both the adrenal gland and vagus nerve contribute to the hyperinsulinemia in the MSG model, although adrenal is more crucial as it appears to modulate parasympathetic activity and M3AChR expression in obesity.

show abstract

“…However, fraction II, which is thought to be a new protein, has not yet been identified. The fraction II had excellent anticancer activity (IC50 value 0.116 mg/ml for 48 h treatment) on human gastric cancer cell line SGC-7901 [73]. Kupradinun et al examined effect of MC against clastogens, cyclophosphamide (CYP), and DMBA using in vivo erythrocyte micronucleus assay in mice and azoxymethane (AOM)-induced colon carcinogenesis in rats.…”

Section: Colon Cancermentioning

confidence: 99%

Bitter Melon as a Therapy for Diabetes, Inflammation, and Cancer: a Panacea?

et al. 2016

View full text Add to dashboard Cite

Natural products have been used for centuries for cures prevention, treatment, and cure of multiple diseases. Some dietary agents are present in multiple systems of medicines as proposed treatments for chronic and difficult to treat diseases. Once such natural product is Momordica charantia or bitter melon. Bitter melon is cultivated in multiple regions across the world, and various parts of the plant, such as fruit, leaves seed, etc. have been shown to possess medicinal properties in ancient literature. Over the last few decades, multiple well-structured scientific studies have been performed to study the effects of bitter melon in various diseases. Some of the properties for which bitter melon has been studied include: antioxidant, antidiabetic, anticancer, anti-inflammatory, antibacterial, antifungal, antiviral, anti-HIV, anthelmintic, hypotensive, anti-obesity, immuno-modulatory, antihyperlipidemic, hepato-protective, and neuro-protective activities. This review attempts to summarize the various literature findings regarding medicinal properties of bitter melon. With such strong scientific support on so many medicinal claims, bitter melon comes close to being considered a panacea.

show abstract

Maternal green tea extract supplementation to rats fed a high-fat diet ameliorates insulin resistance in adult male offspring

Cited by 35 publications

References 44 publications

Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

Oxyresveratrol Supplementation to C57bl/6 Mice Fed with a High-Fat Diet Ameliorates Obesity-Associated Symptoms

HPA axis and vagus nervous function are involved in impaired insulin secretion of MSG-obese rats

Bitter Melon as a Therapy for Diabetes, Inflammation, and Cancer: a Panacea?

Contact Info

Product

Resources

About