Maternal haemolysis, elevated liver enzymes and low platelets syndrome: Perinatal and neurodevelopmental neonatal outcomes for infants weighing less than 1250 g

Abstract

Improved health outcomes occur with increased gestational age. Infants with BWT less than 1250 g born to women with HELLP syndrome were not at risk of increased neurodevelopmental disability compared to controls.

The HELLP syndrome: Clinical issues and management. A Review

“…Neonatal thrombocytopenia occurs in between 15% and 38% of cases [ 5 , 93 ] and is a significant risk factor for both intraventricular haemorrhage (IVH) and long-term neurological complications [ 5 , 94 ].…”

“…The neonatal outcome of the HELLP syndrome represents a controversy [ 94 ]. Some authors report that infants born to mothers with a HELLP syndrome are more likely to be small for gestational age (SGA) and to have increased risk of perinatal asphyxia and RDS [ 94 ] and that the respiratory and cardiovascular morbidity may be further aggravated by maternal HELLP occurring before 32 weeks' gestation [ 95 ]. A retrospective study was published in 2003 by Roelofsen et al .…”

“…A total of 109 infants (mean gestational age 32.6 weeks, mean birth weight 1766 g) were born by 104 women with HELLP syndrome. There were no significant differences in gender, Apgar score, need for resuscitation, RDS, sepsis, NEC or death in the neonatal unit, suggesting that infants born to mothers with a HELLP syndrome are not at increased risk for mortality or morbidity and that the majority of neonatal complications were attributable to prematurity [ 94 ]. There was a significant decrease in mortality and morbidity with increasing gestational age and birth weight.…”

“…No significant differences in neonatal mortality and morbidity were found in infants weighing less than 1250 g compared to the weight matched control group. At 3 years of age, the HELLP group had fewer children with cerebral palsy (CP) and mental disability [ 94 ].…”

Characteristics of Hellp Syndrome in Severe Preeclampsia Patients in Dr. Soetomo Hospital Surabaya

“…Supported by Singhal et al (2004), the average of gestational age when labor performed was 32,6 in HELLPs group. In this study, HELLPs group had the average 33-34 weeks of gestational age when labor performed, while in non-HELLPs group the average was 36-37 weeks of gestational age.…”