Maternal Hepatitis B Virus Infection and Pregnancy Outcomes

Wan, Zhihua; Zhou, Aifen; Zhu, Huiping; Lin, Xin; Hu, Dan; Peng, Songxu; Zhang, Bin; Du, Yukai

doi:10.1097/mcg.0000000000000842

Cited by 29 publications

(38 citation statements)

References 31 publications

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“…We found that women with HBsAg positive status were tended to be slightly older than women with HBsAg negative status. This result is consistent with those of other studies, which also showed that women infected with the hepatitis B virus were more likely to be older [15][16][17]. Moreover, there is evidence that the number of abnormal blood glucose cases during pregnancy is higher among those with an HBsAg positive status than among those with an HBsAgnegative status.…”

Section: Discussionsupporting

confidence: 92%

Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Zhao

Chen²,

Song

et al. 2020

PLoS ONE

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Objective Hepatitis B virus infection is a major social and economic burden in developing countries, especially in China. We aimed to evaluate the effects of hepatitis B surface antigen (HBsAg) positive status on the pregnancy outcomes in the Chinese population. Methods This retrospective cohort study was performed using data from the Medical Birth Registry of Xiamen, China, from January 2011 to March 2018. Multivariate logistic regression analysis was used to assess the association between the HBsAg status and pregnancy outcomes. Results This study included 3,789 HBsAg-positive women and 29, 648 non-exposed women. The HBsAg-positive pregnant women were slightly older in age (29.3±4.3 vs. 28.9±4.4, P< 0.001). Additionally, pregnant women with a positive HBsAg status had higher odds of gestational diabetes mellitus (GDM) (adjusted odds ratio [aOR], 1.13; 95% confidence interval [CI], 1.03-1.23), and cesarean delivery (aOR, 1.12; 95%CI, 1.03-1.21). The risk of infants being large or small-for-gestational age, having low-birth weight, and of macrosomia, preterm birth, and stillbirth did not differ significantly between the HBsAg-positive and-negative women. Conclusion In Xiamen, China, the slightly higher risk of GDM and cesarean section in women positive for HBsAg should not be neglected. Further studies should be conducted to evaluate the effects of HBsAg positivity on the pregnancy outcomes in different ethnic populations.

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Section: Discussionsupporting

confidence: 92%

Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Zhao

Chen²,

Song

et al. 2020

PLoS ONE

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“…Cui et al (7) reported that miscarriage (but not stillbirth) was significantly associated with maternal HBV status when compared to HBV-negative mothers. Miscarriage and stillbirth are usually caused by other negative outcomes during pregnancy, which include pregnancyinduced hypertension, fetal distress, and macrosomia (14).…”

Section: Discussionmentioning

confidence: 99%

“…Our study had several limitations, most importantly the relatively small sample size along with several relatively rare outcomes. Other studies previously assessed other factors such as gestational diabetes, pre-eclampsia, and placental abruption, which we were unable to evaluate (10,14).…”

mentioning

confidence: 84%

Maternal Hepatitis B Virus Infection, Pregnancy, and Infant Health Outcomes in Botswana

et al. 2019

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Background: Hepatitis B virus (HBV) infection during pregnancy is associated with an increased risk of premature birth, cesarean sections, low birth weight, and an increased number of hospitalizations in infants. There are no reported data on the impact of maternal HBV status on pregnancy and infant health outcomes in Botswana. Objectives: We aimed to evaluate the association of maternal HBsAg + /occult HBV infection at delivery with pregnancy and infant health outcomes in Botswana. Methods: HBsAg positivity was tested using a murex HBsAg ELISA kit while occult HBV (OBI) was tested using COBAS ® AmpliPrep COBAS ® Taqman ®. Results: The total number of maternal HBsAg + and OBI infections was 57 out of 752 and termed as maternal HBV. Binary logistic regression was used to explore the possible impact of maternal HBV status on each outcome, adjusted for maternal HIV status, ART use during pregnancy, and maternal age. Conclusions: In conclusion, there was no association between maternal HBsAg + /occult HBV infection and preterm birth (< 37 weeks), stillbirth, low birth weight (< 2.5 kg), and infant hospitalization (by 24 months).

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“…There are studies which have showed severe adverse pregnancy outcome in HBsAg positive mothers and warrant a careful surveillance of maternal HBsAg status and viral activity especially in second trimester. 13…”

Section: Discussionmentioning

confidence: 99%

Prevalence of hepatitis B surface antigen (HBsAg) in asymptomatic pregnant women and in the cord blood of their newborns

Jha

2018

Int J Community Med Public Health

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Background: In a developing country like India there is very high incidence and prevalence of hepatitis B. The disease is easy to prevent than to treat. Pregnant females are exposed more to risk factors than the general population which makes them a more apt candidate for HBsAg screening. This shall help both the mother (in terms of treatment) and newborn (in terms of prophylaxis and if not successful then, treatment).Methods: This study was conducted on 111 patients who were divided into two groups of asymptomatic cases and symptomatic cases i.e. those patients who were jaundiced. ELISA was used for detection of HBsAg in the maternal and the cord blood of their newborn.Results: Maximun incidence of sero-positivity was seen in age group between 20-25yrs and second pregnancy was associated with maximum HBsAg positivity. Asymptomatic cases showed only 10.41% sero-positivity whereas it was 60% in clinically jaundiced cases (p<0.05). Also rate of vertical transmission was 66.6% in the diseased group. Obstetric complications like premature labour, early rupture of membrane were also observed in the study.Conclusions: This study helped us to know the prevalence and the various other association of HBsAg positivity both in clinically asymptomatic cases and symptomatic cases. Thus we conclude that HBsAg screening should be mandatory for all pregnant females and in areas where resources a scarce at least high risk cases should be screened. This shall help to break the chain of mother to child transmission (MTCT) of this dreaded disease.

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Maternal Hepatitis B Virus Infection and Pregnancy Outcomes

Cited by 29 publications

References 31 publications

Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Effects of maternal hepatitis B surface antigen positive status on the pregnancy outcomes: A retrospective study in Xiamen, China, 2011-2018

Maternal Hepatitis B Virus Infection, Pregnancy, and Infant Health Outcomes in Botswana

Prevalence of hepatitis B surface antigen (HBsAg) in asymptomatic pregnant women and in the cord blood of their newborns

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