Maternal high-fat diet modifies epigenetic marks H3K27me3 and H3K27ac in bone to regulate offspring osteoblastogenesis in mice

Chen, Jin‐Ran; Caviness, Perry C.; Zhao, Hongyan; Belcher, Beau; Wankhade, Umesh D.; Shankar, Kartik; Blackburn, Michael L.; Lazarenko, Oxana P.

doi:10.1080/15592294.2022.2111759

Cited by 6 publications

(1 citation statement)

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“…Maternal obesity has been associated with an increase in the expression of senescence genes of osteoprogenitors through the acetylation of H3K27ac [ 159 ]. The expression of osteoblastogenesis-associated genes such as Pthlh and Col2α1 was synergistically decreased through significantly enriched H3K27me3 and H3K27ac in dams of HFD-fed maternal mice [ 160 ]. The diet has also been shown to influence the nutrition status of the cells, which provides different metabolites for epigenetic activities.…”

Section: The Role Of Environmental Factors In Msc Aging and Diseasementioning

confidence: 99%

Impact of Environmental and Epigenetic Changes on Mesenchymal Stem Cells during Aging

Smith

Shirazi

Cakouros

et al. 2023

IJMS

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Many crucial epigenetic changes occur during early skeletal development and throughout life due to aging, disease and are heavily influenced by an individual’s lifestyle. Epigenetics is the study of heritable changes in gene expression as the result of changes in the environment without any mutation in the underlying DNA sequence. The epigenetic profiles of cells are dynamic and mediated by different mechanisms, including histone modifications, non-coding RNA-associated gene silencing and DNA methylation. Given the underlining role of dysfunctional mesenchymal tissues in common age-related skeletal diseases such as osteoporosis and osteoarthritis, investigations into skeletal stem cells or mesenchymal stem cells (MSC) and their functional deregulation during aging has been of great interest and how this is mediated by an evolving epigenetic landscape. The present review describes the recent findings in epigenetic changes of MSCs that effect growth and cell fate determination in the context of aging, diet, exercise and bone-related diseases.

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Section: The Role Of Environmental Factors In Msc Aging and Diseasementioning

confidence: 99%