Maternal nickel exposure and congenital musculoskeletal defects

Vaktskjold, Arild; Talykova, Ljudmila; Chashchin, Valery; Odland, Jon Øyvind; Nieboer, Evert

doi:10.1002/ajim.20609

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…However, use of official monitoring data in the assessment of BD prevalences likely involve less rigorous data collection than that exercised for birth registers, and perhaps is also prone to under-reporting less severe forms of defects. Our prevalence estimates of genital malformations and defects of musculoskeletal system were lower than those reported for Monchegorsk by Vaktskjold et al [ 8 , 9 ]. Our neural tube and anterior abdominal wall defect prevalences were also lower than those reported for Arkhangelsk by Petrova and Vaktskjold as incidences (abortions after 12 weeks of gestation were included) [ 10 , 11 ].…”

Section: Discussioncontrasting

confidence: 91%

“…In addition, 102 newborns with age 13–27 weeks of gestation were also registered, of which 82 were stillborn or died during the first week of life. Details of the construction and description of the register’s suitability for epidemiological investigations have been published [ 8 , 9 , 16 ]. A total number of 26 841 pregnancy outcomes were registered.…”

Section: Methodsmentioning

confidence: 99%

“…For the period March 1973 through 2002, Vaktskjold et al reported a high prevalence (13.3/1000 of newborns) of musculoskeletal malformations in Monchegorsk [ 8 ], but not of genital defects (4.4/1000 newborns) [ 9 ]. Furthermore, for 1995–2004 Petrova and Vaktskjold found a higher incidence of neural tube defects (2.1/1000 newborns and abortions) in Arkhangelsk, Russia than in Norway [ 10 ]; by contrast, the incidences of anterior abdominal wall defects were the same (0.5/1000 newborns and abortions) [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study

et al. 2015

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BackgroundBirth defects (BD) constitute an important public health issue as they are the main cause of infant death. Their prevalence in Europe for 2008–2012 was 25.6 per 1000 newborns. To date, there are no population-based studies for the Russian Federation. The aim of the present study is to estimate the prevalence of BD, its forms, and changes over time in the Russian Arctic city of Monchegorsk (Murmansk County) for the period 1973–2011.MethodsThe Murmansk County Birth Register and the Kola Birth Register were the primary sources of information, covering 30448 pregnancy outcomes in Monchegorsk (Murmansk County, Russia) during the study period.ResultsThe total perinatal prevalence of BD was 36.1/1000 live births (LB) and stillborn (SB) (95% CI = 34.0-38.2). After exclusions of minor malformations according to the European Surveillance of Congenital Anomalies guidelines, it decreased to 26.5/1000 LB plus SB (95% CI = 24.6-28.3). The perinatal prevalence of BD that are obligatory to report in Russia was 7.3/1000 LB plus SB (95% CI = 6.4-8.3). There was a significant positive time-trend in total perinatal prevalence of birth defects across the study period (p < 0.001 for trend). Prevalence of all BD increased from 23.5/1000 to 46.3/1000 (LB plus SB), while that excluding minor defects rose from 17.7/1000 to 35.7/1000 (LB plus SB). The most prevalent group of defects was malformations of the musculoskeletal system, which represented 35.4% of all BD. The most prominent increase was observed for the urinary system, rising from 0.2/1000 to 19.1/1000 (LB plus SB).ConclusionsThe observed perinatal prevalence of BD in Monchegorsk increased two-fold during the 38-year study period. Further investigations to identify the underlying bases for the observed progressive growth in BD are recommended.

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Section: Discussioncontrasting

confidence: 91%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study

et al. 2015

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“…[35] Prenatal iron deficiency has also been linked to neurocognitive developmental effects in early childhood. [38] Vitamin B 12 (cobalamin, a cobalt compound) deficiencies in maternal diets have been linked to low fetal growth and other adverse symptoms including cleft palate. [39] Nutritional deficiencies are very frequently observed in developing countries, making dietary uptake and maternal health an urgent health equity issue.…”

Section: Discussionmentioning

confidence: 99%

“…[41] Maternal occupational exposure to nickel has been found to be linked to the development of musculoskeletal birth defects. [38] Elevated lead levels are observed in children in developing countries, which can have a strongly adverse effect on neurocognitive development. [42] Arsenic exposure from the water supply has been observed in some eastern Asian countries including Bangladesh, which can result in neurocognitive effects and other health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Harrington

Young

Fry

et al. 2015

Biol Trace Elem Res

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Trace elements can play an important role in maternal health and fetal development, and deficiencies in some essential minerals including zinc and copper have been correlated in some individuals to the development of birth defects and adverse health outcomes later in life. The exact etiology of conditions like preeclampsia and the effects of fetal exposure to toxic metals has not been determined, making the assessment of trace element levels crucial to the elucidation of the causes of conditions like preeclampsia. Previous studies analyzing serum and placenta tissue have produced conflicting findings, suggesting the need for a robust, validated sample preparation and analysis method for the determination of trace elements in placenta. In this report, an acid digestion method and analysis by ICP-MS for a broad metallomics/mineralomics panel of trace elements is developed and validated over three experimental days for inter- and intraday precision and accuracy, linear range, matrix impact, and dilution verification. Spike recovery experiments were performed for the essential elements chromium (Cr), iron (Fe), cobalt (Co), nickel (Ni), copper (Cu), and zinc (Zn), and the toxic elements arsenic (As), cadmium (Cd), and lead (Pb) at levels equal to and in excess of native concentrations in control placenta tissue. The validated method will be essential for the development of scientific studies of maternal health and toxic metal exposure effects in childhood.

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Determination of cytogenetic abnormalities in buccal mucosa of dental laboratory technicians

Yüksel

Yıldırım

2021

Archives of Environmental & Occupational Health

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Maternal nickel exposure and congenital musculoskeletal defects

Cited by 11 publications

References 37 publications

Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study

Prevalence of birth defects in an Arctic Russian setting from 1973 to 2011: a register-based study

Validation of a Metallomics Analysis of Placenta Tissue by Inductively-Coupled Plasma Mass Spectrometry

Determination of cytogenetic abnormalities in buccal mucosa of dental laboratory technicians

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