Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers

Isaac, Alinny Rosendo; Velasco, Patricia Coelho de; Fraga, Karla Yasmin Dias; Tavares-do-Carmo, Maria das Graças; Campos, Raquel Maria Pereira; Iannotti, Fabio Arturo; Verde, Roberta; Martins, Danyelly Bruneska Gondim; Santos, Thaysa Aragão; Ferreira, Bruna Klippel; Mello, Fernando G. de; Marzo, Vincenzo Di; Andrade-da-Costa, Belmira Lara da Silveira; Reis, Ricardo Augusto de Melo

doi:10.1016/j.jnutbio.2021.108782

Cited by 8 publications

(8 citation statements)

References 112 publications

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“…PUFAs increased DHA, DHEA, and EPEA levels in the cerebrum of neonatal offspring, 102 and improved their memory performance later in life. 103 These data corroborate observations in humans on a direct link between maternal and fetal circulation and placental fatty acid transfer, and the ability of PUFAs to modify adult behaviors with ω-6 PUFAs and ω-3 PUFAs being antagonistic (risk vs. resilience) factors, respectively.…”

Section: Modified Experimental Diets During Pregnancy and Their Devel...mentioning

confidence: 89%

“…91,100 It is noteworthy that a lowered maternal intake of DHA directly led to a reduction in DHEA ("synaptamide") in the fetal brain, 101 which could exceed an 80% loss when ω-3 PUFAs were removed from the maternal diet. 69,102 In contrast, enrichment of the maternal diet in ω-3…”

Section: Modified Experimental Diets During Pregnancy and Their Devel...mentioning

confidence: 99%

“…To manipulate the ω‐3 PUFA content of the brain, an experimental diet deficient in ω‐3 PUFAs (LA: 74.4% of total lipids; ALA: 0.3% of total lipids; ω‐6/ω‐3 ratio 121.4 ± 1.9) decreased its DHA content, 90,92 and allowed associations between low DHA levels and anxiety‐ and depressive‐like symptoms, 90,92 as well as impaired learning 91,100 . It is noteworthy that a lowered maternal intake of DHA directly led to a reduction in DHEA (“synaptamide”) in the fetal brain, 101 which could exceed an 80% loss when ω‐3 PUFAs were removed from the maternal diet 69,102 . In contrast, enrichment of the maternal diet in ω‐3 PUFAs increased DHA, DHEA, and EPEA levels in the cerebrum of neonatal offspring, 102 and improved their memory performance later in life 103 .…”

Section: Maternal Diet As a Risk Factor For Mental Disorders In Their...mentioning

confidence: 99%

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Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Cinquina

Keimpema

Pollak

et al. 2023

J Neuroendocrinology

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Obesity is a key medical challenge of our time. The increasing number of children born to overweight or obese women is alarming. During pregnancy, the circulation of the mother and her fetus interact to maintain the uninterrupted availability of essential nutrients for fetal organ development. In doing so, the mother's dietary preference determines the amount and composition of nutrients reaching the fetus. In particular, the availability of polyunsaturated fatty acids (PUFAs), chiefly their ω‐3 and ω‐6 subclasses, can change when pregnant women choose a specific diet. Here, we provide a succinct overview of PUFA biochemistry, including exchange routes between ω‐3 and ω‐6 PUFAs, the phenotypes, and probable neurodevelopmental disease associations of offspring born to mothers consuming specific PUFAs, and their mechanistic study in experimental models to typify signaling pathways, transcriptional, and epigenetic mechanisms by which PUFAs can imprint long‐lasting modifications to brain structure and function. We emphasize that the ratio, rather than the amount of individual ω‐3 or ω‐6 PUFAs, might underpin physiologically correct cellular differentiation programs, be these for neurons or glia, during pregnancy. Thereupon, the PUFA‐driven programming of the brain is contextualized for childhood obesity, metabolic, and endocrine illnesses.

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Section: Modified Experimental Diets During Pregnancy and Their Devel...mentioning

confidence: 89%

Section: Modified Experimental Diets During Pregnancy and Their Devel...mentioning

confidence: 99%

Section: Maternal Diet As a Risk Factor For Mental Disorders In Their...mentioning

confidence: 99%

See 1 more Smart Citation

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Cinquina

Keimpema

Pollak

et al. 2023

J Neuroendocrinology

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“…This system is responsible for the regulation of several physiological processes in the Central Nervous System (CNS), endocrine, immune, gastrointestinal, and reproductive systems, among others ( Di Marzo et al, 1998 ; Aizpurua-Olaizola et al, 2017 ). The endocannabinoids are mainly bioactive lipids derived from the cleavage of membrane fatty acids and phospholipids, and their levels can be modulated by diet, exercise and lifestyle ( de Melo Reis et al, 2021 ; Isaac et al, 2021 ; Sihag and Di Marzo, 2022 ).…”

Section: Endocannabinoid Systemmentioning

confidence: 99%

Phytocannabinoids and Cannabis-Based Products as Alternative Pharmacotherapy in Neurodegenerative Diseases: From Hypothesis to Clinical Practice

Paes-Colli

Aguiar

Isaac

et al. 2022

Front. Cell. Neurosci.

Self Cite

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Historically, Cannabis is one of the first plants to be domesticated and used in medicine, though only in the last years the amount of Cannabis-based products or medicines has increased worldwide. Previous preclinical studies and few published clinical trials have demonstrated the efficacy and safety of Cannabis-based medicines in humans. Indeed, Cannabis-related medicines are used to treat multiple pathological conditions, including neurodegenerative disorders. In clinical practice, Cannabis products have already been introduced to treatment regimens of Alzheimer’s disease, Parkinson’s disease and Multiple Sclerosis’s patients, and the mechanisms of action behind the reported improvement in the clinical outcome and disease progression are associated with their anti-inflammatory, immunosuppressive, antioxidant, and neuroprotective properties, due to the modulation of the endocannabinoid system. In this review, we describe the role played by the endocannabinoid system in the physiopathology of Alzheimer, Parkinson, and Multiple Sclerosis, mainly at the neuroimmunological level. We also discuss the evidence for the correlation between phytocannabinoids and their therapeutic effects in these disorders, thus describing the main clinical studies carried out so far on the therapeutic performance of Cannabis-based medicines.

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“…Thus, n-3 PUFA and the ECS modulate several functions through neurodevelopment including synaptic plasticity mechanisms. Our group has recently shown that changes in maternal dietary DHA levels may impact differently on the ECS and molecular markers highlighted by increased synaptophysin levels in the neonate brain, CB1/2 receptor levels in dams and neonates' brain, glial fibrillary acidic protein (GFAP) levels, and protein kinase A (PKA) phosphorylation in the cortex and ERK phosphorylation in the hippocampus of the progeny (Isaac et al, 2021).…”

Section: Healthy Diet Supplements and Natural Productsmentioning

confidence: 99%

Quality of Life and a Surveillant Endocannabinoid System

et al. 2021

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The endocannabinoid system (ECS) is an important brain modulatory network. ECS regulates brain homeostasis throughout development, from progenitor fate decision to neuro- and gliogenesis, synaptogenesis, brain plasticity and circuit repair, up to learning, memory, fear, protection, and death. It is a major player in the hypothalamic-peripheral system-adipose tissue in the regulation of food intake, energy storage, nutritional status, and adipose tissue mass, consequently affecting obesity. Loss of ECS control might affect mood disorders (anxiety, hyperactivity, psychosis, and depression), lead to drug abuse, and impact neurodegenerative (Alzheimer’s, Parkinson, Huntington, Multiple, and Amyotrophic Lateral Sclerosis) and neurodevelopmental (autism spectrum) disorders. Practice of regular physical and/or mind-body mindfulness and meditative activities have been shown to modulate endocannabinoid (eCB) levels, in addition to other players as brain-derived neurotrophic factor (BDNF). ECS is involved in pain, inflammation, metabolic and cardiovascular dysfunctions, general immune responses (asthma, allergy, and arthritis) and tumor expansion, both/either in the brain and/or in the periphery. The reason for such a vast impact is the fact that arachidonic acid, a precursor of eCBs, is present in every membrane cell of the body and on demand eCBs synthesis is regulated by electrical activity and calcium shifts. Novel lipid (lipoxins and resolvins) or peptide (hemopressin) players of the ECS also operate as regulators of physiological allostasis. Indeed, the presence of cannabinoid receptors in intracellular organelles as mitochondria or lysosomes, or in nuclear targets as PPARγ might impact energy consumption, metabolism and cell death. To live a better life implies in a vigilant ECS, through healthy diet selection (based on a balanced omega-3 and -6 polyunsaturated fatty acids), weekly exercises and meditation therapy, all of which regulating eCBs levels, surrounded by a constructive social network. Cannabidiol, a diet supplement has been a major player with anti-inflammatory, anxiolytic, antidepressant, and antioxidant activities. Cognitive challenges and emotional intelligence might strengthen the ECS, which is built on a variety of synapses that modify human behavior. As therapeutically concerned, the ECS is essential for maintaining homeostasis and cannabinoids are promising tools to control innumerous targets.

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Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers

Cited by 8 publications

References 112 publications

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Adverse effects of gestational ω‐3 and ω‐6 polyunsaturated fatty acid imbalance on the programming of fetal brain development

Phytocannabinoids and Cannabis-Based Products as Alternative Pharmacotherapy in Neurodegenerative Diseases: From Hypothesis to Clinical Practice

Quality of Life and a Surveillant Endocannabinoid System

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