Maternal Peripheral T-Helper 1-Type and T-Helper 2-Type Immunity in Nonpreeclamptic Twin Pregnancies

Abstract

The percentage of T-helper (Th)1, Th2 cells and the Th1:Th2 cell ratios in peripheral blood from 14 normal nonpregnant women, 23 normal pregnant women and 9 patients with twin pregnancies without preeclampsia at 28–32 weeks’ gestation were calculated using flow cytometry. In normal pregnant women, the percentage of Th1 cells and Th1:Th2 ratios were significantly lower than those in nonpregnant women. In twin pregnancies, the percentage of Th1 cells and the Th1:Th2 ratios were significantly lower than those in nonpregnancies. In twin pregnancies; in addition, the percentage of Th1 cells was significantly lower than that in singleton pregnancies. Our findings show a markedly predominant Th2 immunity in twin pregnancies.

Sex‐specific influence of the vacuolar adenosine triphosphatase a2 isoform on outcome in twin pregnancies

“…An elevated level of the Th2 subclass of T lymphocytes and a decreased Th1-Th2 T lymphocyte ratio has been observed in mothers with twins compared to those with singleton pregnancies. 17,18 In the present study, we evaluated if a2V levels in peripheral blood mononuclear cells (PBMCs) were different depending on fetal sex, and if this was reflected in associations with birthweight and gestational age at delivery.…”

Preeklamptik Hastalarda Adenozin Deaminaz Gen Polimorfizmi

“…Suzuki ve ark. preeklamptik olmayan ikiz gebeliklerde hücresel immünitenin varlığını saptamak için yayınladıları bir makalede ikiz gebelikte belirgin bir Th-2 hücre immünitesinin olduğunun saptadılar 27 . Aynı araştırmacı grubu, 2003'te benzer bir araştırma ile preeklamptik olmayan ikiz gebeliklerde adenozinin uterin kan akımı regülasyonundaki rolünü araştırdılar ve ikiz gebeliklerdeki vasküler rezistanstaki azalmanın adenozinden bağımsız olabileceği sonucuna vardılar 28 .…”