Maternal physical activity significantly alters the placental transcriptome

Loiselle, Julie J.; Fatica, Thet; Tzaneva, Velislava; Vuong, Nhung; Holčı́k, Martin; Adamo, Kristi B.

doi:10.1016/j.placenta.2020.08.016

Cited by 6 publications

(4 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Given that most of the associations were reported with ST during early to middle gestation, a potential explanation is that reducing ST during this period might have induced diverse structural, metabolic and molecular changes in placental cells that remain throughout pregnancy until parturition, 28–30,43 and might dictate placental phenotype 5,20,28–30 . However, we cannot fully exclude that there might also be an acute influence of currently unknown drivers in later pregnancy that account for placental alterations.…”

Section: Discussionmentioning

confidence: 91%

“…However, there is a paucity of evidence about the influence of lifestyle on placental transporters and the underlying mechanisms. The few studies exploring this issue have shown that PA modulates the expression of placental molecules involved in glucose, fatty acid, amino acid and water transport, 28–30 and in insulin and mTOR signalling 30 . Nonetheless, these studies were limited to the middle period of gestation and by scarce sample size, and did not explore by which mechanisms ST or PA could alter the expression of placental genes or impact fetal health.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Acosta‐Manzano

Leopold-Posch

Simmons

et al. 2021

BJOG

View full text Add to dashboard Cite

Objective We aimed to explore: (i) the association of sedentary time (ST) and physical activity (PA) during pregnancy with the placental expression of genes related to glucose and lipid metabolism in pregnant women who are obese; (ii) maternal metabolic factors mediating changes in these placental transcripts; and (iii) cord blood markers related to the mRNAs mediating neonatal adiposity. Design Multicentre randomised controlled trial. Setting Hospitals in nine European countries. Population A cohort of 112 pregnant women with placental tissue. Methods Both ST and moderate‐to‐vigorous PA (MVPA) levels were measured objectively using accelerometry at three time periods during pregnancy. Main outcome measures Placental mRNAs (FATP2, FATP3, FABP4, GLUT1 and PPAR‐γ) were measured with NanoString technology. Maternal and fetal metabolic markers and neonatal adiposity were assessed. Results Longer periods of ST, especially in early to middle pregnancy, was associated with lower placental FATP2 and FATP3 expression (P < 0.05), whereas MVPA at baseline was inversely associated with GLUT1 mRNA (P = 0.02). Although placental FATP2 and FATP3 expression were regulated by the insulin–glucose axis (P < 0.05), no maternal metabolic marker mediated the association of ST/MVPA with placental mRNAs (P > 0.05). Additionally, placental FATP2 expression was inversely associated with cord blood triglycerides and free fatty acids (FFAs; P < 0.01). No cord blood marker mediated neonatal adiposity except for cord blood leptin, which mediated the effects of PPAR‐γ on neonatal sum of skinfolds (P < 0.05). Conclusions In early to middle pregnancy, ST is associated with the expression of placental genes linked to lipid transport. PA is hardly related to transporter mRNAs. Strategies aimed at reducing sedentary behaviour during pregnancy could modulate placental gene expression, which may help to prevent unfavourable fetal and maternal pregnancy outcomes. Tweetable abstract Reducing sedentary behaviour in pregnancy might modulate placental expression of genes related to lipid metabolism in women who are obese.

show abstract

Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Acosta‐Manzano

Leopold-Posch

Simmons

et al. 2021

BJOG

View full text Add to dashboard Cite

show abstract

“…Loiselle et al reported significant expression changes in placental genes involved in the transport and localization of nutrients between active and non-active gesP. Most notably, aquaporin genes (AQP1 and AQP9) had higher expression in the placentas of active individuals, suggesting an adaptive response of water and glycerol (Loiselle et al, 2020). Epigenetic modifications, including DNA methylation, play a significant role in regulating gene expression and function.…”

Section: Transcriptomics and Epigenomicsmentioning

confidence: 99%

Physically active pregnancies: Insights from the placenta

Adamo,

Goudreau,

Corson

et al. 2024

Physiological Reports

View full text Add to dashboard Cite

Physical activity (PA) positively influences pregnancy, a critical period for health promotion, and affects placental structure and function in ways previously overlooked. Here, we summarize the current body of literature examining the association between PA, placenta biology, and physiology while also highlighting areas where gaps in knowledge exist. PA during pregnancy induces metabolic changes, influencing nutrient availability and transporter expression in the placenta. Hormones and cytokines secreted during PA contribute to health benefits, with intricate interactions in pro‐ and anti‐inflammatory markers. Extracellular vesicles and placental “‐omics” data suggest that gestational PA can shape placental biology, affecting gene expression, DNA methylation, metabolite profiles, and protein regulation. However, whether cytokines that respond to PA alter placental proteomic profiles during pregnancy remains to be elucidated. The limited research on placenta mitochondria of physically active gestational parents (gesP), has shown improvements in mitochondrial DNA and antioxidant capacity, but the relationship between PA, placental mitochondrial dynamics, and lipid metabolism remains unexplored. Additionally, PA influences the placenta‐immune microenvironment, angiogenesis, and may confer positive effects on neurodevelopment and mental health through placental changes, vascularization, and modulation of brain‐derived neurotrophic factor. Ongoing exploration is crucial for unraveling the multifaceted impact of PA on the intricate placental environment.

show abstract

“…Sedentary behavior is associated with neonatal adiposity [16]. However, little is known about the effect of PA or ST on the placenta, except for moderateto-vigorous PA (MVPA) induced changes in placental transcriptome [26] and an ST induced lower expression of placental genes linked to lipid transport [27].…”

Section: Introductionmentioning

confidence: 99%

Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity

et al. 2022

View full text Add to dashboard Cite

Regular moderate-to-vigorous physical activity (MVPA) and reduced sedentary time (ST) improve maternal glucose metabolism in pregnancy. More MVPA and less ST outside pregnancy increase antioxidant capacity, hence, are beneficial in preventing oxidative stress. The placenta is the first line of defense for the fetus from an adverse maternal environment, including oxidative stress. However, effects of MVPA and ST on oxidative stress markers in the placenta are unknown. The purpose of this study was to assess the association of MVPA and ST in pregnancy with oxidative stress markers in placentas of overweight/obese women (BMI ≥ 29 kg/m2). MVPA and ST were objectively measured with accelerometers at <20 weeks, 24–27 and 35–37 weeks of gestation. Using linear Bayesian multilevel models, the associations of MVPA and ST (mean and changes) with mRNA expression of a panel of 11 oxidative stress related markers were assessed in 96 women. MVPA was negatively correlated with HSP70 mRNA expression in a sex-independent manner and with GCLM expression only in placentas of female fetuses. ST was positively associated with HO-1 mRNA expression in placentas of male neonates. None of the other markers were associated with MVPA or ST. We speculate that increasing MVPA and reducing ST attenuates the oxidative stress state in placentas of obese pregnant women.

show abstract

Maternal physical activity significantly alters the placental transcriptome

Cited by 6 publications

References 58 publications

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

The unexplored role of sedentary time and physical activity in glucose and lipid metabolism‐related placental mRNAs in pregnant women who are obese: the DALI lifestyle randomised controlled trial

Physically active pregnancies: Insights from the placenta

Physical Activity and Sedentary Time in Pregnancy: An Exploratory Study on Oxidative Stress Markers in the Placenta of Women with Obesity

Contact Info

Product

Resources

About