Maternal plasma lipid concentrations in early pregnancy and risk of preeclampsia*1

Abstract

Early pregnancy dyslipidemia is associated with an increased risk of preeclampsia. This association may be significant in understanding the pathologic processes of preeclampsia and may help in developing strategies for prevention or early diagnosis of the disorder.

Study of serum lipid profile in pregnancy induced hypertension

“…Though in our own study, the mean value of HDL-C was about 30% higher in the third trimester of normal pregnancy over the nonpregnant women, but statistically the alteration was not significant (P>0.05). A tendency to lesser quantities of serum alpha lipoprotein fraction in women with toxaemia, particularly in the third trimester, was reported by many workers (6,7,9). In our study a significant decrease in HDL-C were observed in pre-eclamptic and eclamptic pregnant women.…”

“…In present study there was a significant fall in LDL-C : HDL-C in normal pregnant women as compared to nonpregnant women. LDL-C : HDL-C however increased significantly in eclamptic women as compared to normal pregnant women (6,10). On the contrary, HDL-C : VLDL-C continued to fall in both preeclampsia and eclampsia.…”

Shared biomarkers between female diastolic heart failure and pre‐eclampsia: a systematic review and meta‐analysis

“…Twenty‐seven studies reported on HDL levels,32, 37, 41, 44, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74 of which 24 studies could be included in a meta‐analysis 32, 37, 41, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72. HDL level was lower in pre‐eclampsia than in controls (mean difference −6.29 mmol/L; 95%CI −9.74−2.85; P  = 0.0003) with the strongest effect in subgroup analysis for severe pre‐eclampsia vs. controls ( Figure 4).…”

Association of Lipid Profile and Uric Acid with Pre-Eclampsia of Third Trimester in Nullipara Women

“…In addition, the decreased catabolism of TG-rich lipoproteins by reduced placental uptake and the putative concomitant decrease of lipoprotein lipolysis results in the accumulation of TG-rich remnant lipoproteins in the maternal circulation. Remnant lipoproteins may induce platelet activation and endothelial dysfunction, thus leading to the major clinical symptoms of PE [7].…”