Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice

Masuda, Shinnosuke; Ee, Oh Kwan; Sairenji, Taku James; Sato, Seika; Yajima, Hiroyuki; Amano, Izuki; Koibuchi, Noriyuki; Shimokawa, Noriaki

doi:10.1002/dev.22264

Cited by 5 publications

(5 citation statements)

References 27 publications

(31 reference statements)

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“…The PRL secretion patterns were almost identical to previous studies (Fig. 1B) [11,19] However, our results for PRL3B1 significantly conflicted with those of Soares and Talamantes, where their study showed a plateau in serum PRL3B1 levels from G14 until delivery [11], we detected a sharp decline (Fig. 1A).…”

Section: Discussionsupporting

confidence: 76%

“…In mice, luteolysis is triggered by prostaglandin F2α (PGF2α), reducing the expression of PRLR in the corpus luteum [62,63]. Hence, a high PRL3B1 plasma concentration or the exogenous PRL injection cannot prevent luteolysis, the P4 decline, and parturition [19,64]. Our results (Figs.…”

Section: Endocrine Journal Advance Publicationmentioning

confidence: 68%

“…Towards the end of pregnancy, the hypothalamuspituitary axis escapes suppression, and PRL surges on G18 [11,19]. Elevated PRL signals trigger nurturing behavior in the mother [20,21].…”

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confidence: 99%

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Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice

Sairenji,

Masuda,

Higuchi

et al. 2024

Endocr J

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The placenta secretes a prolactin (PRL)-like hormone PRL3B1 (placental lactogen II), a luteotropic hormone essential for maintaining pregnancy until labor in mice. A report from 1984 examined the secretion pattern of PRL3B1 in prepartum mice. In the current study, we found contradictory findings in the secretion pattern that invalidate the previous report. By measuring maternal plasma PRL3B1 and PRL every 4 hrs from gestational day 17 (G17), we newly discovered that maternal plasma PRL3B1 levels decrease rapidly in prepartum C57BL/6 mice. Interestingly, the onset of this decline coincided with the PRL surge at G18, demonstrating a plasma prolactin axis shift from placental to pituitary origin. We also found that maternal plasma progesterone regression precedes the onset of the PRL shift. The level of Prl3b1 mRNA was determined by RT-qPCR in the placenta and remained stable until parturition, implying that PRL3B1 peptide production or secretion was suppressed. We hypothesized that production of the PRL family, the 25 paralogous PRL proteins exclusively expressed in mice placenta, would decrease alongside PRL3B1 during this period. To investigate this hypothesis and to seek proteomic changes, we performed a shotgun proteome analysis of the placental tissue using data-independent acquisition mass spectrometry (DIA-MS). Up to 5,891 proteins were identified, including 17 PRL family members. Relative quantitative analysis between embryonic day 17 (E17) and E18 placentas showed no significant difference in the expression of PRL3B1 and most PRL family members except PRL7C1. These results suggest that PRL3B1 secretion from the placenta is suppressed at G18 (E18).

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Section: Discussionsupporting

confidence: 76%

Section: Endocrine Journal Advance Publicationmentioning

confidence: 68%

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Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice

Sairenji,

Masuda,

Higuchi

et al. 2024

Endocr J

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“…With dynamic changes in placental lactogen production occurring throughout pregnancy, 51 it is possible that differences between DIO and control pregnant mice were not detectable with sampling at a single time point in the present study. While it has been shown that prolactin levels rise in late pregnancy in the mouse, 58 this is the first study to examine serial prolactin levels in the peripartum and determine changes in prolactin concentrations relating to time of birth in mice. Similar to rats (reviewed in Phillipps et al 17 ), mice have a pre‐partum prolactin surge, and in mice this started approximately 18 h before birth and decreased between 3 h pre‐birth and 6 h post‐birth.…”

Section: Discussionmentioning

confidence: 98%

High fat diet‐induced maternal obesity in mice impairs peripartum maternal behaviour

Brown,

Jacobs,

Khant Aung

et al. 2023

J Neuroendocrinology

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Obesity during pregnancy represents a significant health issue and can lead to increased complications during pregnancy and impairments with breastfeeding, along with long‐term negative health consequences for both mother and offspring. In rodent models, diet‐induced obesity (DIO) during pregnancy leads to poor outcomes for offspring. Using a DIO mouse model, consisting of feeding mice a high fat diet for 8 weeks before mating, we recapitulate the effect of high pup mortality within the first 3 days postpartum. To examine the activity of the dam around the time of birth, late pregnant control and DIO dams were recorded in their home cages and the behaviour of the dam immediately before and after birth was analysed. Prior to giving birth, DIO dams spent less time engaging in nesting behaviour, while after birth, DIO dams spent less time in the nest with their pups compared to control dams, indicating reduced pup‐engagement in the early postpartum period. We have previously reported that lactogenic hormone action, mediated by the prolactin receptor, in the medial preoptic area of the hypothalamus (MPOA) is critical for the onset of normal postpartum maternal behaviour. We hypothesized that DIO dams may have lower lactogenic hormone activity during late pregnancy, which would contribute to impaired onset of normal postpartum maternal behaviour. Day 16 lactogenic activity, transport of prolactin into the brain, and plasma prolactin concentrations around birth were all similar in control and DIO dams. Moreover, endogenous pSTAT5, a marker of prolactin receptor activity, in the MPOA was unaffected by DIO. Overall, these data indicate that lactogenic activity in late pregnancy of DIO dams is not different to controls and is unlikely to play a major role in impaired onset of normal postpartum maternal behaviour.

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“…It was summarized that prolactin from the dam may activate certain neural circuits in the fetus that are required for the expression of certain maternal behavioral characteristics such as nurturing ability when fully mature [ 124 ]. However, more recent work by these same authors aimed to emulate this study by artificially lowering prolactin concentrations during pregnancy, and unfortunately did not find the same relationships [ 133 ]. Although different findings between the experiments are apparent, this work may still suggest a possible transgenerational effect associated with the concentration of prolactin that needs to be explored further.…”

Section: Factors Influencing Maternal Behaviormentioning

confidence: 91%

Maternal Behavior in Beef Cattle: The Physiology, Assessment and Future Directions—A Review

Nevard

Pant

Broster

et al. 2022

Veterinary Sciences

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Bovine maternal behavior is known to be influenced by a variety of factors including hormonal mediation, breed, age, parity, host genetics and general management practices. Following centuries of varying levels of domestication processes, the behavior of the bovine cow has altered from that of her original wild ungulate ancestors, although many maternal instincts have remained unchanged. The influence of maternal behavior on calf health and performance is of interest to cow-calf beef production operations, as in most instances, the cow is solely responsible for rearing the calf until weaning. However, investigating the magnitude of this influence is challenging, in part because objective measurement of behavioral traits is difficult, particularly in extensive settings. In recent years, while a number of remote monitoring devices have been developed that afford opportunities for objective measurement of behavioral traits in livestock, characterization of physiological mechanisms that underlie superior maternal behavior, including identification of potential biomarkers remains elusive in cattle. Hormonal profiles during the periparturient period have been shown to influence behavioral patterns in both current and future generations in other mammalian species and may provide insights into the physiology of bovine maternal behavior. Therefore, the aim of this review is to describe general characteristics of bovine maternal behavior and the factors known to influence it, including hormonal drivers, through which cross-reference to other species is made. Current methods of measuring and assessing behavior that may also be applicable to most production settings have also been reviewed. At present, there is no known hormonal assay that can be used to measure and/or reliably predict bovine maternal behavior post-calving or across generations. Being able to objectively assess superior maternal behavior, whether that be through remote monitoring, hormonal profiling or indirectly through measuring calf performance will be beneficial to livestock industries in the future.

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Maternal prolactin levels during late pregnancy and nurturing behavior of offspring in mice

Cited by 5 publications

References 27 publications

Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice

Plasma prolactin axis shift from placental to pituitary origin in late prepartum mice

High fat diet‐induced maternal obesity in mice impairs peripartum maternal behaviour

Maternal Behavior in Beef Cattle: The Physiology, Assessment and Future Directions—A Review

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